High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles

High encapsulation efficiency of sodium alendronate in eudragit S100/HPMC blend microparticles

The hydrophilic drug sodium alendronate was encapsulated in blended microparticles of Eudragit® S100 and Methocel® F4M or Methocel® K100LV. Both formulations prepared by spray-drying showed spherical collapsed shape and smooth surface, encapsulation efficiencies of 85 and 82% and mean diameters of 1...

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Bibliographic Details
Main Authors:	Letícia Cruz, Evelise Assumpção, Sílvia Stanisçuaski Guterres, Adriana Raffin Pohlmann
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Química 2009-01-01
Series:	Química Nova
Subjects:	hydrophilic drug sodium alendronate microparticles
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000500016

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