Subclinical hypothyroidism: psychiatric disorders and symptoms Hipotireoidismo subclínico: transtornos e sintomas psiquiátricos
OBJECTIVE: To evaluate the prevalence of psychiatric disorders and symptoms in patients with subclinical hypothyroidism. METHOD: Ninety-four outpatients with at least two elevated serum thyrotrophin levels (> 4 µU/ml) and normal FT4, and 43 euthyroid outpatients, both groups from HUCFF-UFRJ, were...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Psiquiatria (ABP)
2007-06-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462007000200013 |
| _version_ | 1818016970423926784 |
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| author | Cloyra Almeida Marco Antônio Brasil Antônio José Leal Costa Fabiola A A Reis Vaneska Reuters Patrícia Teixeira Márcia Ferreira Amanda M Marques Bianca A Melo Letícia B B de M Teixeira Alexandre Buescu Mário Vaisman |
| author_facet | Cloyra Almeida Marco Antônio Brasil Antônio José Leal Costa Fabiola A A Reis Vaneska Reuters Patrícia Teixeira Márcia Ferreira Amanda M Marques Bianca A Melo Letícia B B de M Teixeira Alexandre Buescu Mário Vaisman |
| author_sort | Cloyra Almeida |
| collection | DOAJ |
| description | OBJECTIVE: To evaluate the prevalence of psychiatric disorders and symptoms in patients with subclinical hypothyroidism. METHOD: Ninety-four outpatients with at least two elevated serum thyrotrophin levels (> 4 µU/ml) and normal FT4, and 43 euthyroid outpatients, both groups from HUCFF-UFRJ, were evaluated. Psychiatric diagnosis was based on the Structured Clinical Interview Diagnostic for the DSM-IV axis I (SCID-I/DSM-IV), the psychopathological symptoms on Hamilton anxiety and depression scales, and the Beck Inventory. RESULTS: Our data showed an increased prevalence of psychiatric disorders in the subclinical hypothyroidism patients when compared to the euthyroid group (45.7% vs 25.6%; p = 0.025), mood disorders being the most frequent. The prevalence of depressive symptoms based on Beck's Scale among subclinical hypothyroidism patients was about 2.3 times higher than among euthyroid ones (45.6% vs 20.9%, p = 0.006). Anxiety symptoms were also more frequent among subclinical hypothyroidism patients (87.0% vs 60.5%, p < 0.001), mainly clinical anxiety (44.6% vs 23.3%; p = 0.001). CONCLUSION: Our results showed a significant association of subclinical hypothyroidism with psychiatric disorders and an increased frequency of subsyndromic depression and anxiety symptoms in subclinical hypothyroidism in relation to the euthyroid group.<br>OBJETIVO: Avaliar a prevalência de sintomas e alterações psiquiátricas em pacientes com hipotireoidismo subclínico. MÉTODO: Foram estudados 94 pacientes ambulatoriais com pelo menos duas dosagens plasmáticas elevadas de tireotropina (> 4 µU/ml) e com T4 livre normal e, 43 eutireoidianos, ambos os grupos do HUCFF-UFRJ. Para diagnóstico psiquiátrico foi utilizada a entrevista clínica estruturada do eixo I (SCID-I/DSM-IV) e, para sintomas psicopatológicos, as escalas de ansiedade e depressão de Hamilton (HAM-A e HAM-D) e inventário de Beck. RESULTADOS: Encontramos uma prevalência aumentada de transtornos psiquiátricos no hipotireoidismo subclínico em comparação ao grupo eutireoidiano (45,7% vs 25,6%; p = 0,025), sendo o transtorno do humor o de maior freqüência. Sintomas de depressão no grupo com hipotireoidismo subclínico foram cerca de 2,3 vezes mais freqüentes que entre os eutireoidianos (45,6% vs 20,9%; p = 0,006) quando o instrumento utilizado foi a escala de Beck. Da mesma forma, sintomas de ansiedade também foram mais freqüentes no hipotireoidismo subclínico (87,0% vs 60,5%; p < 0,001), principalmente ansiedade clínica (44,6% vs 23,3%; p = 0,001). CONCLUSÃO: Os resultados indicaram uma associação do hipotireoidismo subclínico com os transtornos psiquiátricos, além de uma freqüência aumentada de sintomas de depressão e ansiedade subsindrômicos em relação ao grupo eutireoidiano. |
| first_indexed | 2024-04-14T07:20:28Z |
| format | Article |
| id | doaj.art-451091d7db974480a972fb70729a426e |
| institution | Directory Open Access Journal |
| issn | 1516-4446 1809-452X |
| language | English |
| last_indexed | 2024-04-14T07:20:28Z |
| publishDate | 2007-06-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-451091d7db974480a972fb70729a426e2022-12-22T02:06:10ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1516-44461809-452X2007-06-0129215715910.1590/S1516-44462007000200013Subclinical hypothyroidism: psychiatric disorders and symptoms Hipotireoidismo subclínico: transtornos e sintomas psiquiátricosCloyra AlmeidaMarco Antônio BrasilAntônio José Leal CostaFabiola A A ReisVaneska ReutersPatrícia TeixeiraMárcia FerreiraAmanda M MarquesBianca A MeloLetícia B B de M TeixeiraAlexandre BuescuMário VaismanOBJECTIVE: To evaluate the prevalence of psychiatric disorders and symptoms in patients with subclinical hypothyroidism. METHOD: Ninety-four outpatients with at least two elevated serum thyrotrophin levels (> 4 µU/ml) and normal FT4, and 43 euthyroid outpatients, both groups from HUCFF-UFRJ, were evaluated. Psychiatric diagnosis was based on the Structured Clinical Interview Diagnostic for the DSM-IV axis I (SCID-I/DSM-IV), the psychopathological symptoms on Hamilton anxiety and depression scales, and the Beck Inventory. RESULTS: Our data showed an increased prevalence of psychiatric disorders in the subclinical hypothyroidism patients when compared to the euthyroid group (45.7% vs 25.6%; p = 0.025), mood disorders being the most frequent. The prevalence of depressive symptoms based on Beck's Scale among subclinical hypothyroidism patients was about 2.3 times higher than among euthyroid ones (45.6% vs 20.9%, p = 0.006). Anxiety symptoms were also more frequent among subclinical hypothyroidism patients (87.0% vs 60.5%, p < 0.001), mainly clinical anxiety (44.6% vs 23.3%; p = 0.001). CONCLUSION: Our results showed a significant association of subclinical hypothyroidism with psychiatric disorders and an increased frequency of subsyndromic depression and anxiety symptoms in subclinical hypothyroidism in relation to the euthyroid group.<br>OBJETIVO: Avaliar a prevalência de sintomas e alterações psiquiátricas em pacientes com hipotireoidismo subclínico. MÉTODO: Foram estudados 94 pacientes ambulatoriais com pelo menos duas dosagens plasmáticas elevadas de tireotropina (> 4 µU/ml) e com T4 livre normal e, 43 eutireoidianos, ambos os grupos do HUCFF-UFRJ. Para diagnóstico psiquiátrico foi utilizada a entrevista clínica estruturada do eixo I (SCID-I/DSM-IV) e, para sintomas psicopatológicos, as escalas de ansiedade e depressão de Hamilton (HAM-A e HAM-D) e inventário de Beck. RESULTADOS: Encontramos uma prevalência aumentada de transtornos psiquiátricos no hipotireoidismo subclínico em comparação ao grupo eutireoidiano (45,7% vs 25,6%; p = 0,025), sendo o transtorno do humor o de maior freqüência. Sintomas de depressão no grupo com hipotireoidismo subclínico foram cerca de 2,3 vezes mais freqüentes que entre os eutireoidianos (45,6% vs 20,9%; p = 0,006) quando o instrumento utilizado foi a escala de Beck. Da mesma forma, sintomas de ansiedade também foram mais freqüentes no hipotireoidismo subclínico (87,0% vs 60,5%; p < 0,001), principalmente ansiedade clínica (44,6% vs 23,3%; p = 0,001). CONCLUSÃO: Os resultados indicaram uma associação do hipotireoidismo subclínico com os transtornos psiquiátricos, além de uma freqüência aumentada de sintomas de depressão e ansiedade subsindrômicos em relação ao grupo eutireoidiano.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462007000200013HipotireoidismoTranstornos da ansiedadeTranstornos do humorSintomasPrevalênciaHypothyroidismAnxiety disordersMood disordersSymptomsPrevalence |
| spellingShingle | Cloyra Almeida Marco Antônio Brasil Antônio José Leal Costa Fabiola A A Reis Vaneska Reuters Patrícia Teixeira Márcia Ferreira Amanda M Marques Bianca A Melo Letícia B B de M Teixeira Alexandre Buescu Mário Vaisman Subclinical hypothyroidism: psychiatric disorders and symptoms Hipotireoidismo subclínico: transtornos e sintomas psiquiátricos Brazilian Journal of Psychiatry Hipotireoidismo Transtornos da ansiedade Transtornos do humor Sintomas Prevalência Hypothyroidism Anxiety disorders Mood disorders Symptoms Prevalence |
| title | Subclinical hypothyroidism: psychiatric disorders and symptoms Hipotireoidismo subclínico: transtornos e sintomas psiquiátricos |
| title_full | Subclinical hypothyroidism: psychiatric disorders and symptoms Hipotireoidismo subclínico: transtornos e sintomas psiquiátricos |
| title_fullStr | Subclinical hypothyroidism: psychiatric disorders and symptoms Hipotireoidismo subclínico: transtornos e sintomas psiquiátricos |
| title_full_unstemmed | Subclinical hypothyroidism: psychiatric disorders and symptoms Hipotireoidismo subclínico: transtornos e sintomas psiquiátricos |
| title_short | Subclinical hypothyroidism: psychiatric disorders and symptoms Hipotireoidismo subclínico: transtornos e sintomas psiquiátricos |
| title_sort | subclinical hypothyroidism psychiatric disorders and symptoms hipotireoidismo subclinico transtornos e sintomas psiquiatricos |
| topic | Hipotireoidismo Transtornos da ansiedade Transtornos do humor Sintomas Prevalência Hypothyroidism Anxiety disorders Mood disorders Symptoms Prevalence |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462007000200013 |
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