Chaperonin containing TCP-1 (CCT/TRiC) is a novel therapeutic and diagnostic target for neuroblastoma

Chaperonin containing TCP-1 (CCT/TRiC) is a novel therapeutic and diagnostic target for neuroblastoma

Chaperonin containing TCP1 (CCT/TRiC) is a multi-subunit protein folding complex that enables the cancer phenotype to emerge from the mutational landscape that drives oncogenesis. We and others linked increased expression of CCT subunits to advanced tumor stage and invasiveness that inversely correl...

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Bibliographic Details
Main Authors: Amanda Cox, Daniel Nierenberg, Oscar Camargo, Eunkyung Lee, Amr S. Khaled, Joseph Mazar, Rebecca J. Boohaker, Tamarah J. Westmoreland, Annette R. Khaled
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
cancer
pediatric
peptide
circulating tumor cells
chaperone
protein-folding
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.975088/full

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