Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic Mice
BackgroundThe increasing prevalence of type 2 diabetes mellitus (T2DM) is associated with the rapid spread of obesity. Obesity induces insulin resistance, resulting in β-cell dysfunction and thus T2DM. Green tea extract (GTE) has been known to prevent obesity and T2DM, but this effect is still being...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2013-06-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-196.pdf |
| _version_ | 1818540454440861696 |
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| author | Ki-Cheor Bae Jae-Hyung Park Ann-Yae Na Sun-Joo Kim Shinbyoung Ahn Sang-Pyo Kim Byung-Chul Oh Ho-Chan Cho Yong Woon Kim Dae-Kyu Song |
| author_facet | Ki-Cheor Bae Jae-Hyung Park Ann-Yae Na Sun-Joo Kim Shinbyoung Ahn Sang-Pyo Kim Byung-Chul Oh Ho-Chan Cho Yong Woon Kim Dae-Kyu Song |
| author_sort | Ki-Cheor Bae |
| collection | DOAJ |
| description | BackgroundThe increasing prevalence of type 2 diabetes mellitus (T2DM) is associated with the rapid spread of obesity. Obesity induces insulin resistance, resulting in β-cell dysfunction and thus T2DM. Green tea extract (GTE) has been known to prevent obesity and T2DM, but this effect is still being debated. Our previous results suggested that circulating green tea gallated catechins (GCs) hinders postprandial blood glucose lowering, regardless of reducing glucose and cholesterol absorption when GCs are present in the intestinal lumen. This study aimed to compare the effect of GTE with that of GTE coadministered with poly-γ-glutamic acid (γ-PGA), which is likely to inhibit the intestinal absorption of GCs.MethodsThe db/db mice and age-matched nondiabetic mice were provided with normal chow diet containing GTE (1%), γ-PGA (0.1%), or GTE+γ-PGA (1%:0.1%) for 4 weeks.ResultsIn nondiabetic mice, none of the drugs showed any effects after 4 weeks. In db/db mice, however, weight gain and body fat gain were significantly reduced in the GTE+γ-PGA group compared to nondrug-treated db/db control mice without the corresponding changes in food intake and appetite. Glucose intolerance was also ameliorated in the GTE+γ-PGA group. Histopathological analyses showed that GTE+γ-PGA-treated db/db mice had a significantly reduced incidence of fatty liver and decreased pancreatic islet size. Neither GTE nor γ-PGA treatment showed any significant results.ConclusionThese results suggest that GTE+γ-PGA treatment than GTE or γ-PGA alone may be a useful tool for preventing both obesity and obesity-induced T2DM. |
| first_indexed | 2024-12-11T21:55:34Z |
| format | Article |
| id | doaj.art-451397e76f0249719d04e39310895ecc |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-11T21:55:34Z |
| publishDate | 2013-06-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-451397e76f0249719d04e39310895ecc2022-12-22T00:49:19ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872013-06-0137319620610.4093/dmj.2013.37.3.1962390Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic MiceKi-Cheor BaeJae-Hyung ParkAnn-Yae NaSun-Joo KimShinbyoung AhnSang-Pyo KimByung-Chul OhHo-Chan ChoYong Woon KimDae-Kyu SongBackgroundThe increasing prevalence of type 2 diabetes mellitus (T2DM) is associated with the rapid spread of obesity. Obesity induces insulin resistance, resulting in β-cell dysfunction and thus T2DM. Green tea extract (GTE) has been known to prevent obesity and T2DM, but this effect is still being debated. Our previous results suggested that circulating green tea gallated catechins (GCs) hinders postprandial blood glucose lowering, regardless of reducing glucose and cholesterol absorption when GCs are present in the intestinal lumen. This study aimed to compare the effect of GTE with that of GTE coadministered with poly-γ-glutamic acid (γ-PGA), which is likely to inhibit the intestinal absorption of GCs.MethodsThe db/db mice and age-matched nondiabetic mice were provided with normal chow diet containing GTE (1%), γ-PGA (0.1%), or GTE+γ-PGA (1%:0.1%) for 4 weeks.ResultsIn nondiabetic mice, none of the drugs showed any effects after 4 weeks. In db/db mice, however, weight gain and body fat gain were significantly reduced in the GTE+γ-PGA group compared to nondrug-treated db/db control mice without the corresponding changes in food intake and appetite. Glucose intolerance was also ameliorated in the GTE+γ-PGA group. Histopathological analyses showed that GTE+γ-PGA-treated db/db mice had a significantly reduced incidence of fatty liver and decreased pancreatic islet size. Neither GTE nor γ-PGA treatment showed any significant results.ConclusionThese results suggest that GTE+γ-PGA treatment than GTE or γ-PGA alone may be a useful tool for preventing both obesity and obesity-induced T2DM.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-196.pdf miceDiabetes mellitus, type 2Gallated catechinsGlucose intoleranceObesityPoly-γ-glutamic acid |
| spellingShingle | Ki-Cheor Bae Jae-Hyung Park Ann-Yae Na Sun-Joo Kim Shinbyoung Ahn Sang-Pyo Kim Byung-Chul Oh Ho-Chan Cho Yong Woon Kim Dae-Kyu Song Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic Mice Diabetes & Metabolism Journal mice Diabetes mellitus, type 2 Gallated catechins Glucose intolerance Obesity Poly-γ-glutamic acid |
| title | Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic Mice |
| title_full | Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic Mice |
| title_fullStr | Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic Mice |
| title_full_unstemmed | Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic Mice |
| title_short | Effect of Green Tea Extract/Poly-γ-Glutamic Acid Complex in Obese Type 2 Diabetic Mice |
| title_sort | effect of green tea extract poly γ glutamic acid complex in obese type 2 diabetic mice |
| topic | mice Diabetes mellitus, type 2 Gallated catechins Glucose intolerance Obesity Poly-γ-glutamic acid |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-196.pdf |
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