Increase in clinically recorded type 2 diabetes after colectomy
The colon hosts gut microbes and glucagon-like peptide 1 secreting cells, both of which influence glucose homeostasis. We tested whether colectomy is associated with development of type 2 diabetes. Using nationwide register data, we identified patients who had undergone total colectomy, partial cole...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-10-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/37420 |
| _version_ | 1811201119814156288 |
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| author | Anders B Jensen Thorkild IA Sørensen Oluf Pedersen Tine Jess Søren Brunak Kristine H Allin |
| author_facet | Anders B Jensen Thorkild IA Sørensen Oluf Pedersen Tine Jess Søren Brunak Kristine H Allin |
| author_sort | Anders B Jensen |
| collection | DOAJ |
| description | The colon hosts gut microbes and glucagon-like peptide 1 secreting cells, both of which influence glucose homeostasis. We tested whether colectomy is associated with development of type 2 diabetes. Using nationwide register data, we identified patients who had undergone total colectomy, partial colectomy, or proctectomy. For each colectomy patient, we selected 15 non-colectomy patients who had undergone other surgeries. Compared with non-colectomy patients, patients with total colectomy (n = 3,793) had a hazard ratio (HR) of clinically recorded type 2 diabetes of 1.40 (95% confidence interval [CI], 1.21 to 1.62; p<0.001). Corresponding HRs after right hemicolectomy (n = 10,989), left hemicolectomy (n = 2,513), and sigmoidectomy (n = 13,927) were 1.08 (95% CI, 0.99 to 1.19; p=0.10), 1.41 (95% CI, 1.19 to 1.67; p<0.001) and 1.30 (95% CI, 1.21 to 1.40; p<0.001), respectively. Although we were not able to adjust for several potential confounders, our findings suggest that the left colon may contribute to maintenance of glucose homeostasis. |
| first_indexed | 2024-04-12T02:15:32Z |
| format | Article |
| id | doaj.art-4513d645a6b94ceeb8725c7a67f16a0d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:15:32Z |
| publishDate | 2018-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-4513d645a6b94ceeb8725c7a67f16a0d2022-12-22T03:52:15ZengeLife Sciences Publications LtdeLife2050-084X2018-10-01710.7554/eLife.37420Increase in clinically recorded type 2 diabetes after colectomyAnders B Jensen0Thorkild IA Sørensen1https://orcid.org/0000-0003-4821-430XOluf Pedersen2Tine Jess3Søren Brunak4Kristine H Allin5https://orcid.org/0000-0002-6880-5759Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute for Next Generation Healthcare, Mount Sinai Health System, New York, United StatesNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, DenmarkNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, DenmarkThe colon hosts gut microbes and glucagon-like peptide 1 secreting cells, both of which influence glucose homeostasis. We tested whether colectomy is associated with development of type 2 diabetes. Using nationwide register data, we identified patients who had undergone total colectomy, partial colectomy, or proctectomy. For each colectomy patient, we selected 15 non-colectomy patients who had undergone other surgeries. Compared with non-colectomy patients, patients with total colectomy (n = 3,793) had a hazard ratio (HR) of clinically recorded type 2 diabetes of 1.40 (95% confidence interval [CI], 1.21 to 1.62; p<0.001). Corresponding HRs after right hemicolectomy (n = 10,989), left hemicolectomy (n = 2,513), and sigmoidectomy (n = 13,927) were 1.08 (95% CI, 0.99 to 1.19; p=0.10), 1.41 (95% CI, 1.19 to 1.67; p<0.001) and 1.30 (95% CI, 1.21 to 1.40; p<0.001), respectively. Although we were not able to adjust for several potential confounders, our findings suggest that the left colon may contribute to maintenance of glucose homeostasis.https://elifesciences.org/articles/37420colonenteroendocrine cellsgut microbiotatype 2 diabetes |
| spellingShingle | Anders B Jensen Thorkild IA Sørensen Oluf Pedersen Tine Jess Søren Brunak Kristine H Allin Increase in clinically recorded type 2 diabetes after colectomy eLife colon enteroendocrine cells gut microbiota type 2 diabetes |
| title | Increase in clinically recorded type 2 diabetes after colectomy |
| title_full | Increase in clinically recorded type 2 diabetes after colectomy |
| title_fullStr | Increase in clinically recorded type 2 diabetes after colectomy |
| title_full_unstemmed | Increase in clinically recorded type 2 diabetes after colectomy |
| title_short | Increase in clinically recorded type 2 diabetes after colectomy |
| title_sort | increase in clinically recorded type 2 diabetes after colectomy |
| topic | colon enteroendocrine cells gut microbiota type 2 diabetes |
| url | https://elifesciences.org/articles/37420 |
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