Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson’s Disease

Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson’s Disease

Advances in stem cell technologies open up new avenues for modelling development and diseases. The success of these pursuits, however, relies on the use of cells most relevant to those targeted by the disease of interest, for example, midbrain dopaminergic neurons for Parkinson’s disease. In the pre...

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Bibliographic Details
Main Authors:	Lucia F. Cardo, Jimena Monzón-Sandoval, Zongze Li, Caleb Webber, Meng Li
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	Cells
Subjects:	CRISPR/Cas9 midbrain dopaminergic neuron genome editing human pluripotent stem cell in vitro differentiation Parkinson’s disease
Online Access:	https://www.mdpi.com/2073-4409/12/24/2860

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