The involvement of microRNAs in neurodegenerative diseases
Neurodegenerative diseases (NDDs) originate from loss of neurons in the central nervous system and are severely debilitating. They are worldwide spread and their incidence increases with age so that they are supposed to become more common due to extended life expectancy. Since no cure is available t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00265/full |
| _version_ | 1819081538611970048 |
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| author | Simona eMaciotta Rolandin Simona eMaciotta Rolandin Mirella eMeregalli Yvan eTorrente |
| author_facet | Simona eMaciotta Rolandin Simona eMaciotta Rolandin Mirella eMeregalli Yvan eTorrente |
| author_sort | Simona eMaciotta Rolandin |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDDs) originate from loss of neurons in the central nervous system and are severely debilitating. They are worldwide spread and their incidence increases with age so that they are supposed to become more common due to extended life expectancy. Since no cure is available they have become a major challenge to neurobiology. The increasing relevance of microRNAs (miRNAs) in biology has prompt the scientific society to investigate on their possible involvement in neurodegeneration with the aim to find new therapeutic targets. Indeed the idea of using miRNAs as therapeutic targets is nowadays not far from realization but important issues need to be addressed before moving towards the clinics. With the present review we aim to resume what have been so far disclose on the involvement of miRNAs in NDDs pathogenesis. Furthermore, their expression levels in peripheral tissues of patients affected by NDDs will be here reported in order to evaluate their application as biomarker of disease. Finally the discrepancy, innovation and effectiveness of data collected will be elucidated and discussed. |
| first_indexed | 2024-12-21T20:02:22Z |
| format | Article |
| id | doaj.art-4515307d9e434e8ea3771048c77cf9b9 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-21T20:02:22Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-4515307d9e434e8ea3771048c77cf9b92022-12-21T18:51:57ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-12-01710.3389/fncel.2013.0026560666The involvement of microRNAs in neurodegenerative diseasesSimona eMaciotta Rolandin0Simona eMaciotta Rolandin1Mirella eMeregalli2Yvan eTorrente3Stem Cell Laboratory Dept of Pathophysiology and Tranplantation Università degli Studi di Milano Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Centro Dino FerrariDiabetes Research Institute, University of Miami Miller School of MedicineStem Cell Laboratory Dept of Pathophysiology and Tranplantation Università degli Studi di Milano Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Centro Dino FerrariStem Cell Laboratory Dept of Pathophysiology and Tranplantation Università degli Studi di Milano Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Centro Dino FerrariNeurodegenerative diseases (NDDs) originate from loss of neurons in the central nervous system and are severely debilitating. They are worldwide spread and their incidence increases with age so that they are supposed to become more common due to extended life expectancy. Since no cure is available they have become a major challenge to neurobiology. The increasing relevance of microRNAs (miRNAs) in biology has prompt the scientific society to investigate on their possible involvement in neurodegeneration with the aim to find new therapeutic targets. Indeed the idea of using miRNAs as therapeutic targets is nowadays not far from realization but important issues need to be addressed before moving towards the clinics. With the present review we aim to resume what have been so far disclose on the involvement of miRNAs in NDDs pathogenesis. Furthermore, their expression levels in peripheral tissues of patients affected by NDDs will be here reported in order to evaluate their application as biomarker of disease. Finally the discrepancy, innovation and effectiveness of data collected will be elucidated and discussed.http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00265/fullAlzheimer DiseaseAmyotrophic Lateral SclerosisNeurodegenerative DiseasesmicroRNAbiomarkerParkinson’s disease |
| spellingShingle | Simona eMaciotta Rolandin Simona eMaciotta Rolandin Mirella eMeregalli Yvan eTorrente The involvement of microRNAs in neurodegenerative diseases Frontiers in Cellular Neuroscience Alzheimer Disease Amyotrophic Lateral Sclerosis Neurodegenerative Diseases microRNA biomarker Parkinson’s disease |
| title | The involvement of microRNAs in neurodegenerative diseases |
| title_full | The involvement of microRNAs in neurodegenerative diseases |
| title_fullStr | The involvement of microRNAs in neurodegenerative diseases |
| title_full_unstemmed | The involvement of microRNAs in neurodegenerative diseases |
| title_short | The involvement of microRNAs in neurodegenerative diseases |
| title_sort | involvement of micrornas in neurodegenerative diseases |
| topic | Alzheimer Disease Amyotrophic Lateral Sclerosis Neurodegenerative Diseases microRNA biomarker Parkinson’s disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00265/full |
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