The role of Th17/Treg-mediated immunoregulation in abortion mice
In the study, we investigated the immune factors related to T helper 17 (Th17) cells and T regulatory (Treg) cells in spontaneous abortion mice. The expression of Th17 was analyzed by interleukin (IL)-6, IL-17A secretion, RAR-related orphan receptor γt (RORγt) expression, and proportion of CD4 + IL-...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-03-01
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| Series: | International Journal of Immunopathology and Pharmacology |
| Online Access: | https://doi.org/10.1177/2058739218760354 |
| _version_ | 1818970636155879424 |
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| author | Ning Li Qinglan Qu Qian Yan |
| author_facet | Ning Li Qinglan Qu Qian Yan |
| author_sort | Ning Li |
| collection | DOAJ |
| description | In the study, we investigated the immune factors related to T helper 17 (Th17) cells and T regulatory (Treg) cells in spontaneous abortion mice. The expression of Th17 was analyzed by interleukin (IL)-6, IL-17A secretion, RAR-related orphan receptor γt (RORγt) expression, and proportion of CD4 + IL-17 + cells. The levels of IL-10, transforming growth factor β (TGF-β), Foxp3, and CD4 + Foxp3 + cells were presented the Treg expression. Higher embryo absorption rate was found in spontaneous abortion group than that in normal pregnancy group ( P < 0.01). Compared with the normal pregnancy mice, spontaneous abortion mice showed higher levels of IL-6 and IL-17A and lower levels of IL-10 and TGF-β in serum and in decidua ( P < 0.05). Furthermore, the expressions of Foxp3 and CD4 + Foxp3 + cells were significantly decreased in spontaneous abortion mice than those in normal pregnancy mice ( P < 0.05). However, the levels of RORγt and CD4 + IL-17 + cells remarkably increased in spontaneous abortion mice ( P < 0.05). The results reveal that Th17/Treg cells may play a vital role in immunoregulation during pregnancy. |
| first_indexed | 2024-12-20T14:39:37Z |
| format | Article |
| id | doaj.art-45163204e9f3454da77be7f20a88f365 |
| institution | Directory Open Access Journal |
| issn | 2058-7384 |
| language | English |
| last_indexed | 2024-12-20T14:39:37Z |
| publishDate | 2018-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | International Journal of Immunopathology and Pharmacology |
| spelling | doaj.art-45163204e9f3454da77be7f20a88f3652022-12-21T19:37:20ZengSAGE PublishingInternational Journal of Immunopathology and Pharmacology2058-73842018-03-011610.1177/2058739218760354The role of Th17/Treg-mediated immunoregulation in abortion miceNing Li0Qinglan Qu1Qian Yan2Department of Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, ChinaDepartment of Reproductive Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, ChinaDepartment of Obstetrics, Yantaishan Hospital, Yantai, ChinaIn the study, we investigated the immune factors related to T helper 17 (Th17) cells and T regulatory (Treg) cells in spontaneous abortion mice. The expression of Th17 was analyzed by interleukin (IL)-6, IL-17A secretion, RAR-related orphan receptor γt (RORγt) expression, and proportion of CD4 + IL-17 + cells. The levels of IL-10, transforming growth factor β (TGF-β), Foxp3, and CD4 + Foxp3 + cells were presented the Treg expression. Higher embryo absorption rate was found in spontaneous abortion group than that in normal pregnancy group ( P < 0.01). Compared with the normal pregnancy mice, spontaneous abortion mice showed higher levels of IL-6 and IL-17A and lower levels of IL-10 and TGF-β in serum and in decidua ( P < 0.05). Furthermore, the expressions of Foxp3 and CD4 + Foxp3 + cells were significantly decreased in spontaneous abortion mice than those in normal pregnancy mice ( P < 0.05). However, the levels of RORγt and CD4 + IL-17 + cells remarkably increased in spontaneous abortion mice ( P < 0.05). The results reveal that Th17/Treg cells may play a vital role in immunoregulation during pregnancy.https://doi.org/10.1177/2058739218760354 |
| spellingShingle | Ning Li Qinglan Qu Qian Yan The role of Th17/Treg-mediated immunoregulation in abortion mice International Journal of Immunopathology and Pharmacology |
| title | The role of Th17/Treg-mediated immunoregulation in abortion mice |
| title_full | The role of Th17/Treg-mediated immunoregulation in abortion mice |
| title_fullStr | The role of Th17/Treg-mediated immunoregulation in abortion mice |
| title_full_unstemmed | The role of Th17/Treg-mediated immunoregulation in abortion mice |
| title_short | The role of Th17/Treg-mediated immunoregulation in abortion mice |
| title_sort | role of th17 treg mediated immunoregulation in abortion mice |
| url | https://doi.org/10.1177/2058739218760354 |
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