Age-specific differences in the dynamics of protective immunity to influenza
Protective immunity after influenza virus infection is poorly understood. Here, the authors quantify the dynamics of immunity against influenza A virus infections by fitting individual-level mechanistic models to longitudinal serology, and find that the form and dynamics of protection differ between...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09652-6 |
| _version_ | 1819126256450404352 |
|---|---|
| author | Sylvia Ranjeva Rahul Subramanian Vicky J. Fang Gabriel M. Leung Dennis K. M. Ip Ranawaka A. P. M. Perera J. S. Malik Peiris Benjamin J. Cowling Sarah Cobey |
| author_facet | Sylvia Ranjeva Rahul Subramanian Vicky J. Fang Gabriel M. Leung Dennis K. M. Ip Ranawaka A. P. M. Perera J. S. Malik Peiris Benjamin J. Cowling Sarah Cobey |
| author_sort | Sylvia Ranjeva |
| collection | DOAJ |
| description | Protective immunity after influenza virus infection is poorly understood. Here, the authors quantify the dynamics of immunity against influenza A virus infections by fitting individual-level mechanistic models to longitudinal serology, and find that the form and dynamics of protection differ between children and adults. |
| first_indexed | 2024-12-22T07:53:09Z |
| format | Article |
| id | doaj.art-4516db8cd934415db46e3d01cea39990 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:53:09Z |
| publishDate | 2019-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4516db8cd934415db46e3d01cea399902022-12-21T18:33:26ZengNature PortfolioNature Communications2041-17232019-04-0110111110.1038/s41467-019-09652-6Age-specific differences in the dynamics of protective immunity to influenzaSylvia Ranjeva0Rahul Subramanian1Vicky J. Fang2Gabriel M. Leung3Dennis K. M. Ip4Ranawaka A. P. M. Perera5J. S. Malik Peiris6Benjamin J. Cowling7Sarah Cobey8Department of Ecology and Evolution, University of ChicagoDepartment of Ecology and Evolution, University of ChicagoWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson BuildingWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson BuildingWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson BuildingWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson BuildingWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson BuildingWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Patrick Manson BuildingDepartment of Ecology and Evolution, University of ChicagoProtective immunity after influenza virus infection is poorly understood. Here, the authors quantify the dynamics of immunity against influenza A virus infections by fitting individual-level mechanistic models to longitudinal serology, and find that the form and dynamics of protection differ between children and adults.https://doi.org/10.1038/s41467-019-09652-6 |
| spellingShingle | Sylvia Ranjeva Rahul Subramanian Vicky J. Fang Gabriel M. Leung Dennis K. M. Ip Ranawaka A. P. M. Perera J. S. Malik Peiris Benjamin J. Cowling Sarah Cobey Age-specific differences in the dynamics of protective immunity to influenza Nature Communications |
| title | Age-specific differences in the dynamics of protective immunity to influenza |
| title_full | Age-specific differences in the dynamics of protective immunity to influenza |
| title_fullStr | Age-specific differences in the dynamics of protective immunity to influenza |
| title_full_unstemmed | Age-specific differences in the dynamics of protective immunity to influenza |
| title_short | Age-specific differences in the dynamics of protective immunity to influenza |
| title_sort | age specific differences in the dynamics of protective immunity to influenza |
| url | https://doi.org/10.1038/s41467-019-09652-6 |
| work_keys_str_mv | AT sylviaranjeva agespecificdifferencesinthedynamicsofprotectiveimmunitytoinfluenza AT rahulsubramanian agespecificdifferencesinthedynamicsofprotectiveimmunitytoinfluenza AT vickyjfang agespecificdifferencesinthedynamicsofprotectiveimmunitytoinfluenza AT gabrielmleung agespecificdifferencesinthedynamicsofprotectiveimmunitytoinfluenza AT denniskmip agespecificdifferencesinthedynamicsofprotectiveimmunitytoinfluenza AT ranawakaapmperera agespecificdifferencesinthedynamicsofprotectiveimmunitytoinfluenza AT jsmalikpeiris agespecificdifferencesinthedynamicsofprotectiveimmunitytoinfluenza AT benjaminjcowling agespecificdifferencesinthedynamicsofprotectiveimmunitytoinfluenza AT sarahcobey agespecificdifferencesinthedynamicsofprotectiveimmunitytoinfluenza |