High Reflectivity and Low Reflectivity Properties on OCTA Influence the Detection of Macular Neovascularization in AMD
Background: In this study, we aimed to discriminate high reflectivity and low reflectivity macular neovascularization (MNV) lesions secondary to age-related macular degeneration (AMD)and to assess the influence of blood flow features on the amount of MNV detected by optical coherence tomography angi...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Physics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphy.2021.694035/full |
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| author | Alessandro Arrigo Emanuela Aragona Alessandro Bordato Alessia Amato Andrea Saladino Francesco Bandello Maurizio Battaglia Parodi |
| author_facet | Alessandro Arrigo Emanuela Aragona Alessandro Bordato Alessia Amato Andrea Saladino Francesco Bandello Maurizio Battaglia Parodi |
| author_sort | Alessandro Arrigo |
| collection | DOAJ |
| description | Background: In this study, we aimed to discriminate high reflectivity and low reflectivity macular neovascularization (MNV) lesions secondary to age-related macular degeneration (AMD)and to assess the influence of blood flow features on the amount of MNV detected by optical coherence tomography angiography (OCTA).Methods: The study was designed as observational, cross-sectional. Type 1 and type 2 MNV lesions were included. All the patients underwent fluorescein angiography (FA), indocyanine green angiography (ICGA) and OCTA. MNV size was calculated on early FA for type 2 MNV and on both early and late phases of ICGA for type 1 lesions. From OCTA, we calculated both MNV size and MNV reflectivity. We assessed the agreement between FA/ICGA and OCTA MNV sizes. Moreover, we studied the relationship between MNV reflectivity properties and MNV OCTA detection.Results: Fifty eyes (50 patients) were included. MNV was identified as follows: 35 /70%) type 1 and 15 (30%) type 2. We found a good agreement between early ICGA size and OCTA size for type 1 MNV (2.10 ± 1.91 mm2 vs 2.09 ± 1.87 mm2; p > 0.05), whereas MNV lesions turned out to be remarkably bigger on late ICGA phase (3.41 ± 2.87 mm2; p < 0.01). Interestingly, OCTA well-matched with FA in terms of MNV size for type 2 lesions (2.36 ± 2.15 mm2 vs 2.37 ± 2.25 mm2). MNV reflectivity was higher in type 2 MNV and it was strongly associated with the OCTA ability to reconstruct the neovascular network.Conclusion: Our study quantitatively showed that MNV filling pattern and MNV blood flow reflectivity features influence the OCTA detection of the MNV in its entirety. |
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| format | Article |
| id | doaj.art-451a8e0c136a4df58e417cfd125e19a8 |
| institution | Directory Open Access Journal |
| issn | 2296-424X |
| language | English |
| last_indexed | 2024-12-17T01:42:00Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physics |
| spelling | doaj.art-451a8e0c136a4df58e417cfd125e19a82022-12-21T22:08:17ZengFrontiers Media S.A.Frontiers in Physics2296-424X2021-06-01910.3389/fphy.2021.694035694035High Reflectivity and Low Reflectivity Properties on OCTA Influence the Detection of Macular Neovascularization in AMDAlessandro ArrigoEmanuela AragonaAlessandro BordatoAlessia AmatoAndrea SaladinoFrancesco BandelloMaurizio Battaglia ParodiBackground: In this study, we aimed to discriminate high reflectivity and low reflectivity macular neovascularization (MNV) lesions secondary to age-related macular degeneration (AMD)and to assess the influence of blood flow features on the amount of MNV detected by optical coherence tomography angiography (OCTA).Methods: The study was designed as observational, cross-sectional. Type 1 and type 2 MNV lesions were included. All the patients underwent fluorescein angiography (FA), indocyanine green angiography (ICGA) and OCTA. MNV size was calculated on early FA for type 2 MNV and on both early and late phases of ICGA for type 1 lesions. From OCTA, we calculated both MNV size and MNV reflectivity. We assessed the agreement between FA/ICGA and OCTA MNV sizes. Moreover, we studied the relationship between MNV reflectivity properties and MNV OCTA detection.Results: Fifty eyes (50 patients) were included. MNV was identified as follows: 35 /70%) type 1 and 15 (30%) type 2. We found a good agreement between early ICGA size and OCTA size for type 1 MNV (2.10 ± 1.91 mm2 vs 2.09 ± 1.87 mm2; p > 0.05), whereas MNV lesions turned out to be remarkably bigger on late ICGA phase (3.41 ± 2.87 mm2; p < 0.01). Interestingly, OCTA well-matched with FA in terms of MNV size for type 2 lesions (2.36 ± 2.15 mm2 vs 2.37 ± 2.25 mm2). MNV reflectivity was higher in type 2 MNV and it was strongly associated with the OCTA ability to reconstruct the neovascular network.Conclusion: Our study quantitatively showed that MNV filling pattern and MNV blood flow reflectivity features influence the OCTA detection of the MNV in its entirety.https://www.frontiersin.org/articles/10.3389/fphy.2021.694035/fullage-related macular degenerationoptical coherence tomography angiographymacular neovascularizationfluorescein angiographyindocyanine green angiography |
| spellingShingle | Alessandro Arrigo Emanuela Aragona Alessandro Bordato Alessia Amato Andrea Saladino Francesco Bandello Maurizio Battaglia Parodi High Reflectivity and Low Reflectivity Properties on OCTA Influence the Detection of Macular Neovascularization in AMD Frontiers in Physics age-related macular degeneration optical coherence tomography angiography macular neovascularization fluorescein angiography indocyanine green angiography |
| title | High Reflectivity and Low Reflectivity Properties on OCTA Influence the Detection of Macular Neovascularization in AMD |
| title_full | High Reflectivity and Low Reflectivity Properties on OCTA Influence the Detection of Macular Neovascularization in AMD |
| title_fullStr | High Reflectivity and Low Reflectivity Properties on OCTA Influence the Detection of Macular Neovascularization in AMD |
| title_full_unstemmed | High Reflectivity and Low Reflectivity Properties on OCTA Influence the Detection of Macular Neovascularization in AMD |
| title_short | High Reflectivity and Low Reflectivity Properties on OCTA Influence the Detection of Macular Neovascularization in AMD |
| title_sort | high reflectivity and low reflectivity properties on octa influence the detection of macular neovascularization in amd |
| topic | age-related macular degeneration optical coherence tomography angiography macular neovascularization fluorescein angiography indocyanine green angiography |
| url | https://www.frontiersin.org/articles/10.3389/fphy.2021.694035/full |
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