Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial Fibrillation
The increase in the life expectancy of the population is accompanied by an increase in the prevalence of diseases for which old and senile age are risk factors. Atrial fibrillation (AF) and chronic kidney disease (CKD) are two diseases that can coexist in a patient. The risk of ac thromboembolic an...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2022-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/2621 |
| _version_ | 1797232081892278272 |
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| author | T. V. Pavlova |
| author_facet | T. V. Pavlova |
| author_sort | T. V. Pavlova |
| collection | DOAJ |
| description | The increase in the life expectancy of the population is accompanied by an increase in the prevalence of diseases for which old and senile age are risk factors. Atrial fibrillation (AF) and chronic kidney disease (CKD) are two diseases that can coexist in a patient. The risk of ac thromboembolic and hemorrhagic events in this case increases due to the mutual aggravating influence of these diseases. In addition, these patients have a high incidence of coronary events, and cardiovascular complications are the main cause of death in patients with AF and CKD. Consequently, such patients require an integrated approach to treatment, and their management is a complex clinical task. The direct oral anticoagulant rivaroxaban has been most studied in a population of comorbid AF and CKD patients and has proven a high efficacy and safety profile in these patients in randomized controlled trials. In addition, rivaroxaban has shown a significant reduction in the risk of myocardial infarction in various patients, as well as the possibility of preserving renal function to a greater extent compared with warfarin therapy, and a possible positive effect on reducing the risk of cognitive impairment. A single dosing regimen can improve adherence to treatment, which is one of the key conditions for achieving the above effects. Thus, these factors make it possible to achieve comprehensive protection of comorbid patients with AF and CKD. |
| first_indexed | 2024-03-08T13:59:57Z |
| format | Article |
| id | doaj.art-451c854245d543b29ec3f69fa0a2069c |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:54:37Z |
| publishDate | 2022-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-451c854245d543b29ec3f69fa0a2069c2024-04-01T07:43:41ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532022-01-0117691692610.20996/1819-6446-2021-12-081964Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial FibrillationT. V. Pavlova0Samara State Medical UniversityThe increase in the life expectancy of the population is accompanied by an increase in the prevalence of diseases for which old and senile age are risk factors. Atrial fibrillation (AF) and chronic kidney disease (CKD) are two diseases that can coexist in a patient. The risk of ac thromboembolic and hemorrhagic events in this case increases due to the mutual aggravating influence of these diseases. In addition, these patients have a high incidence of coronary events, and cardiovascular complications are the main cause of death in patients with AF and CKD. Consequently, such patients require an integrated approach to treatment, and their management is a complex clinical task. The direct oral anticoagulant rivaroxaban has been most studied in a population of comorbid AF and CKD patients and has proven a high efficacy and safety profile in these patients in randomized controlled trials. In addition, rivaroxaban has shown a significant reduction in the risk of myocardial infarction in various patients, as well as the possibility of preserving renal function to a greater extent compared with warfarin therapy, and a possible positive effect on reducing the risk of cognitive impairment. A single dosing regimen can improve adherence to treatment, which is one of the key conditions for achieving the above effects. Thus, these factors make it possible to achieve comprehensive protection of comorbid patients with AF and CKD.https://www.rpcardio.online/jour/article/view/2621atrial fibrillationchronic kidney diseasecomorbid conditionsanticoagulantsadherence to treatment |
| spellingShingle | T. V. Pavlova Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial Fibrillation Рациональная фармакотерапия в кардиологии atrial fibrillation chronic kidney disease comorbid conditions anticoagulants adherence to treatment |
| title | Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial Fibrillation |
| title_full | Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial Fibrillation |
| title_fullStr | Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial Fibrillation |
| title_full_unstemmed | Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial Fibrillation |
| title_short | Renal Function Protection as an Important Component of a Comprehensive Approach to the Management of Patients with Atrial Fibrillation |
| title_sort | renal function protection as an important component of a comprehensive approach to the management of patients with atrial fibrillation |
| topic | atrial fibrillation chronic kidney disease comorbid conditions anticoagulants adherence to treatment |
| url | https://www.rpcardio.online/jour/article/view/2621 |
| work_keys_str_mv | AT tvpavlova renalfunctionprotectionasanimportantcomponentofacomprehensiveapproachtothemanagementofpatientswithatrialfibrillation |