Autophagy in renal fibrosis: Protection or promotion?
Autophagy is a process that degrades endogenous cellular protein aggregates and damaged organelles via the lysosomal pathway to maintain cellular homeostasis and energy production. Baseline autophagy in the kidney, which serves as a quality control system, is essential for cellular metabolism and or...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.963920/full |
| _version_ | 1818083025119870976 |
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| author | Rong Dai Lei Zhang Hua Jin Dong Wang Meng Cheng Tian Sang Chuyi Peng Yue Li Yiping Wang |
| author_facet | Rong Dai Lei Zhang Hua Jin Dong Wang Meng Cheng Tian Sang Chuyi Peng Yue Li Yiping Wang |
| author_sort | Rong Dai |
| collection | DOAJ |
| description | Autophagy is a process that degrades endogenous cellular protein aggregates and damaged organelles via the lysosomal pathway to maintain cellular homeostasis and energy production. Baseline autophagy in the kidney, which serves as a quality control system, is essential for cellular metabolism and organelle homeostasis. Renal fibrosis is the ultimate pathological manifestation of progressive chronic kidney disease. In several experimental models of renal fibrosis, different time points, stimulus intensities, factors, and molecular mechanisms mediating the upregulation or downregulation of autophagy may have different effects on renal fibrosis. Autophagy occurring in a single lesion may also exert several distinct biological effects on renal fibrosis. Thus, whether autophagy prevents or facilitates renal fibrosis remains a complex and challenging question. This review explores the different effects of the dual regulatory function of autophagy on renal fibrosis in different renal fibrosis models, providing ideas for future work in related basic and clinical research. |
| first_indexed | 2024-12-10T19:31:26Z |
| format | Article |
| id | doaj.art-451c99a2fa504f5292866a1f50b7c749 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T19:31:26Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-451c99a2fa504f5292866a1f50b7c7492022-12-22T01:36:14ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.963920963920Autophagy in renal fibrosis: Protection or promotion?Rong Dai0Lei Zhang1Hua Jin2Dong Wang3Meng Cheng4Tian Sang5Chuyi Peng6Yue Li7Yiping Wang8Department of Chinese Medicine, Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Nephrology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Nephrology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Nephrology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Nephrology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaGraduate School, Anhui University of Chinese Medicine, Hefei, ChinaGraduate School, Anhui University of Chinese Medicine, Hefei, ChinaBlood Purification Center, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Nephrology, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaAutophagy is a process that degrades endogenous cellular protein aggregates and damaged organelles via the lysosomal pathway to maintain cellular homeostasis and energy production. Baseline autophagy in the kidney, which serves as a quality control system, is essential for cellular metabolism and organelle homeostasis. Renal fibrosis is the ultimate pathological manifestation of progressive chronic kidney disease. In several experimental models of renal fibrosis, different time points, stimulus intensities, factors, and molecular mechanisms mediating the upregulation or downregulation of autophagy may have different effects on renal fibrosis. Autophagy occurring in a single lesion may also exert several distinct biological effects on renal fibrosis. Thus, whether autophagy prevents or facilitates renal fibrosis remains a complex and challenging question. This review explores the different effects of the dual regulatory function of autophagy on renal fibrosis in different renal fibrosis models, providing ideas for future work in related basic and clinical research.https://www.frontiersin.org/articles/10.3389/fphar.2022.963920/fullautophagyfibrosisrenal fibrosisdual regulationexperimental model |
| spellingShingle | Rong Dai Lei Zhang Hua Jin Dong Wang Meng Cheng Tian Sang Chuyi Peng Yue Li Yiping Wang Autophagy in renal fibrosis: Protection or promotion? Frontiers in Pharmacology autophagy fibrosis renal fibrosis dual regulation experimental model |
| title | Autophagy in renal fibrosis: Protection or promotion? |
| title_full | Autophagy in renal fibrosis: Protection or promotion? |
| title_fullStr | Autophagy in renal fibrosis: Protection or promotion? |
| title_full_unstemmed | Autophagy in renal fibrosis: Protection or promotion? |
| title_short | Autophagy in renal fibrosis: Protection or promotion? |
| title_sort | autophagy in renal fibrosis protection or promotion |
| topic | autophagy fibrosis renal fibrosis dual regulation experimental model |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.963920/full |
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