Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary Neuropathies
Backgrounds: We have aimed to establish nerve ultrasound reference data in 8 to 17-year-old children and adolescents and to compare those data to younger children, adults, and age-matched children with polyneuropathies.Methods: High-resolution ultrasounds of the nerves were performed in 117 healthy...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00303/full |
| _version_ | 1818873180640509952 |
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| author | Anna-Sophie Grimm Charlotte Schubert Alexander Grimm Jan-Hendrik Stahl Jan-Hendrik Stahl Hanna Küpper Veronka Horber Josua Kegele Josua Kegele Josua Kegele Sophia Willikens Sophia Willikens Julia Wittlinger Lina Serna-Higuita Natalie Winter Natalie Winter Samuel Groeschel |
| author_facet | Anna-Sophie Grimm Charlotte Schubert Alexander Grimm Jan-Hendrik Stahl Jan-Hendrik Stahl Hanna Küpper Veronka Horber Josua Kegele Josua Kegele Josua Kegele Sophia Willikens Sophia Willikens Julia Wittlinger Lina Serna-Higuita Natalie Winter Natalie Winter Samuel Groeschel |
| author_sort | Anna-Sophie Grimm |
| collection | DOAJ |
| description | Backgrounds: We have aimed to establish nerve ultrasound reference data in 8 to 17-year-old children and adolescents and to compare those data to younger children, adults, and age-matched children with polyneuropathies.Methods: High-resolution ultrasounds of the nerves were performed in 117 healthy children and adolescents at 20 predefined landmarks in the neck and the extremities of both sides. Mean values, side-to-side differences and intraneural ratios, as well as upper limits have been calculated. In a second step, a comparison between 25 children and adolescents of the same age range with proven hereditary and acquired neuropathies and lysosomal storage diseases has been carried out.Results: Nerve growth correlates significantly with age and reaches adult values at the age of around 15 years. The influence of body mass index and gender is negligible at most segments. By the use of age-specific upper limits, nerve enlargement could be seen in distinct types of neuropathies, particularly in demyelinating hereditary and inflammatory types, which is comparable to findings in adults, but also in rare lysosomal storage diseases.Conclusion: Nerve size correlates with age during childhood and reaches a climax in younger adults. Age-matched reference data are inevitable to differ between hypertrophic and non-hypertrophic nerve damage, e.g., in neuropathies. |
| first_indexed | 2024-12-19T12:50:37Z |
| format | Article |
| id | doaj.art-4520057ad8c04a0ba36b3c8de04b8fd0 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-19T12:50:37Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4520057ad8c04a0ba36b3c8de04b8fd02022-12-21T20:20:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-04-011110.3389/fneur.2020.00303517206Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary NeuropathiesAnna-Sophie Grimm0Charlotte Schubert1Alexander Grimm2Jan-Hendrik Stahl3Jan-Hendrik Stahl4Hanna Küpper5Veronka Horber6Josua Kegele7Josua Kegele8Josua Kegele9Sophia Willikens10Sophia Willikens11Julia Wittlinger12Lina Serna-Higuita13Natalie Winter14Natalie Winter15Samuel Groeschel16Department of Pediatric Neurology, University Children's Hospital Tübingen, Tübingen, GermanyDepartment of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, GermanyDepartment of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, GermanyDepartment of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, GermanyCenter of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, GermanyDepartment of Pediatric Neurology, University Children's Hospital Tübingen, Tübingen, GermanyDepartment of Pediatric Neurology, University Children's Hospital Tübingen, Tübingen, GermanyDepartment of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, GermanyCenter of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, GermanyUniversity Hospital Tübingen, Neurology, Tübingen, GermanyDepartment of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, GermanyUniversity Hospital Tübingen, Neurology, Tübingen, GermanyUniversity Hospital Tübingen, Neurology, Tübingen, GermanyDepartment of Clinical Epidemiology and Applied Biostatistics, Tübingen University, Tübingen, GermanyDepartment of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, GermanyCenter of Neurology and Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, GermanyDepartment of Pediatric Neurology, University Children's Hospital Tübingen, Tübingen, GermanyBackgrounds: We have aimed to establish nerve ultrasound reference data in 8 to 17-year-old children and adolescents and to compare those data to younger children, adults, and age-matched children with polyneuropathies.Methods: High-resolution ultrasounds of the nerves were performed in 117 healthy children and adolescents at 20 predefined landmarks in the neck and the extremities of both sides. Mean values, side-to-side differences and intraneural ratios, as well as upper limits have been calculated. In a second step, a comparison between 25 children and adolescents of the same age range with proven hereditary and acquired neuropathies and lysosomal storage diseases has been carried out.Results: Nerve growth correlates significantly with age and reaches adult values at the age of around 15 years. The influence of body mass index and gender is negligible at most segments. By the use of age-specific upper limits, nerve enlargement could be seen in distinct types of neuropathies, particularly in demyelinating hereditary and inflammatory types, which is comparable to findings in adults, but also in rare lysosomal storage diseases.Conclusion: Nerve size correlates with age during childhood and reaches a climax in younger adults. Age-matched reference data are inevitable to differ between hypertrophic and non-hypertrophic nerve damage, e.g., in neuropathies.https://www.frontiersin.org/article/10.3389/fneur.2020.00303/fullnerve ultrasoundchildren neuropathyreference valueslysosomal storage diseasesnerve imaging |
| spellingShingle | Anna-Sophie Grimm Charlotte Schubert Alexander Grimm Jan-Hendrik Stahl Jan-Hendrik Stahl Hanna Küpper Veronka Horber Josua Kegele Josua Kegele Josua Kegele Sophia Willikens Sophia Willikens Julia Wittlinger Lina Serna-Higuita Natalie Winter Natalie Winter Samuel Groeschel Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary Neuropathies Frontiers in Neurology nerve ultrasound children neuropathy reference values lysosomal storage diseases nerve imaging |
| title | Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary Neuropathies |
| title_full | Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary Neuropathies |
| title_fullStr | Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary Neuropathies |
| title_full_unstemmed | Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary Neuropathies |
| title_short | Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary Neuropathies |
| title_sort | normative observational nerve ultrasound values in school age children and adolescents and their application to hereditary neuropathies |
| topic | nerve ultrasound children neuropathy reference values lysosomal storage diseases nerve imaging |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00303/full |
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