Panax notoginseng Saponins Alleviate Coronary Artery Disease Through Hypermethylation of the miR-194-MAPK Pathway

Panax notoginseng Saponins Alleviate Coronary Artery Disease Through Hypermethylation of the miR-194-MAPK Pathway

Background:Panax notoginseng saponins (PNS) may have an inhibitory effect against coronary artery disease (CAD); however, the mechanism is unclear. Recent research has begun to evaluate the role of epigenetics in CAD. Our team found that hypomethylation of miR-194 could be an important mechanism of...

Full description

Bibliographic Details
Main Authors:	Lian Duan, Yongmei Liu, Jun Li, Yun Zhang, Yan Dong, Chao Liu, Jie Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Pharmacology
Subjects:	Panax notoginseng saponins coronary artery disease DNA methylation miRNA MAPK
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.829416/full

Similar Items

Dammarane-type Triterpene Saponins from the Flowers of Panax notoginseng
by: Isao Kouno, et al.
Published: (2009-06-01)

Stereoisomers of Saponins in Panax notoginseng (Sanqi): A Review
by: Ming Peng, et al.
Published: (2018-03-01)

Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam
by: Thu Dang Kim, et al.
Published: (2016-09-01)

New dammarane-type triterpenoid saponins from Panax notoginseng saponins
by: Qian Li, et al.
Published: (2020-09-01)

5,6-Didehydroginsenosides from the Roots of Panax notoginseng
by: Jian-Bo Wan, et al.
Published: (2010-11-01)

High nitrogen inhibits biomass and saponins accumulation in a medicinal plant Panax notoginseng
by: Zhu Cun, et al.
Published: (2023-02-01)

Panax Notoginseng Saponins Promote Endothelial Progenitor Cell Mobilization and Attenuate Atherosclerotic Lesions in Apolipoprotein E Knockout Mice
by: Ya Liu, et al.
Published: (2013-09-01)

An instant beverage rich in nutrients and secondary metabolites manufactured from stems and leaves of Panax notoginseng
by: Zhengwei Liang, et al.
Published: (2022-12-01)

Panax notoginseng saponins prevent dementia and oxidative stress in brains of SAMP8 mice by enhancing mitophagy
by: Yingying Yang, et al.
Published: (2024-04-01)

Steamed Panax notoginseng and its Saponins Inhibit the Migration and Induce the Apoptosis of Neutrophils in a Zebrafish Tail-Fin Amputation Model
by: Yin Xiong, et al.
Published: (2022-07-01)

High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq
by: Junyun Cheng, et al.
Published: (2023-04-01)

Panax notoginseng preparation plus aspirin versus aspirin alone on platelet aggregation and coagulation in patients with coronary heart disease or ischemic stroke: A meta-analysis of randomized controlled trials
by: Lulu Dai, et al.
Published: (2022-12-01)

Inhibitory Influence of Panax notoginseng Saponins on Aspirin Hydrolysis in Human Intestinal Caco-2 Cells
by: Zongxi Sun, et al.
Published: (2018-02-01)

Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway
by: Qingqing Li, et al.
Published: (2020-01-01)

Transcriptomics and Metabolomics Changes Triggered by Inflorescence Removal in Panax notoginseng (Burk.)
by: Yu Bai, et al.
Published: (2021-11-01)

Adsorption Characteristics of Rosin-based Macroporous Adsorption Resin for Panax notoginseng Saponin
by: Yingli HU, et al.
Published: (2022-02-01)

Advancements in research on the effects of panax notoginseng saponin constituents in ameliorating learning and memory disorders
by: Shusen Liu, et al.
Published: (2024-04-01)

Therapeutic effects of Panax notoginseng saponins in rheumatoid arthritis: network pharmacology and experimental validation
by: Xinnan Ma, et al.
Published: (2022-06-01)

Panax Notoginseng Saponins as a Novel Nature Stabilizer for Poorly Soluble Drug Nanocrystals: A Case Study with Baicalein
by: Yuanbiao Xie, et al.
Published: (2016-08-01)

Saponins from Panax notoginseng ameliorate steroid resistance in lupus nephritis through regulating lymphocyte-derived exosomes in mice
by: Jia Chen, et al.
Published: (2022-09-01)

Transformation of Panax notoginseng saponins by steaming and Trichoderma longibrachiatum
by: Feng Ge, et al.
Published: (2016-01-01)

Panax notoginseng Saponins for Treating Coronary Artery Disease: A Functional and Mechanistic Overview
by: Lian Duan, et al.
Published: (2017-10-01)

Panax notoginseng saponins alleviate damage to the intestinal barrier and regulate levels of intestinal microbes in a rat model of chronic kidney disease
by: Jing Xie, et al.
Published: (2022-12-01)

Comparative Analysis of Compatibility Influence on Invigorating Blood Circulation for Combined Use of Panax Notoginseng Saponins and Aspirin Using Metabolomics Approach
by: Zongxi Sun, et al.
Published: (2021-04-01)

DPYSL2 is a novel regulator for neural stem cell differentiation in rats: revealed by Panax notoginseng saponin administration
by: Liu-Lin Xiong, et al.
Published: (2020-04-01)

Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng
by: Jia-Huan Shang, et al.
Published: (2019-05-01)

Physicochemical, Digestive, and Sensory Properties of Panax Notoginseng Saponins Encapsulated by Polymerized Whey Protein
by: Zengjia Zhou, et al.
Published: (2021-11-01)

Panax notoginseng extract and total saponin suppress diet-induced obesity and endoplasmic reticulum stress in epididymal white adipose tissue in mice
by: Yi Tan, et al.
Published: (2022-06-01)

Antidepressant Effects of Ginsenosides from Panax notoginseng
by: Yang YAO, et al.
Published: (2012-03-01)

Lowering Nitrogen and Increasing Potassium Application Level Can Improve the Yield and Quality of Panax notoginseng
by: Xiaohong Ou, et al.
Published: (2020-12-01)

Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation
by: Mei-Yu Shen, et al.
Published: (2023-12-01)

Panax notoginseng saponins increases the blood concentration of nifedipine by inhibiting CYP3A4 enzyme through PXR- and CAR-Mediated pathway
by: Qiu-Hong Li, et al.
Published: (2021-01-01)

Lysozyme Improves the Inhibitory Effects of Panax notoginseng Saponins on Phenotype Transformation of Vascular Smooth Muscle Cells by Binding to Ginsenoside Re
by: Yun Huang, et al.
Published: (2021-12-01)

Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats
by: Qian Xiao, et al.
Published: (2022-11-01)

Panax notoginseng saponins reverse steroid resistance in lupus nephritis: Involvement of the suppression of exosomal P-gp levels from lymphocytes to glomerular endothelial cells
by: Feng Pan, et al.
Published: (2023-12-01)

Exogenous leucine alleviates heat stress and improves saponin synthesis in Panax notoginseng by improving antioxidant capacity and maintaining metabolic homeostasis
by: Haijiao Liu, et al.
Published: (2023-04-01)

Personalized bioconversion of Panax notoginseng saponins mediated by gut microbiota between two different diet-pattern healthy subjects
by: Li Wang, et al.
Published: (2021-07-01)

Preparation, optimization, and in vivo evaluation of an inhaled solution of total saponins of Panax notoginseng and its protective effect against idiopathic pulmonary fibrosis
by: Mengjiao Liu, et al.
Published: (2020-01-01)

Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice
by: Hao Hu, et al.
Published: (2021-12-01)

Effect of Panax notoginseng Saponins on Focal Cerebral Ischemia-Reperfusion in Rat Models: A Meta-Analysis
by: Tao Sun, et al.
Published: (2021-02-01)