Inhalation-modulated detection of olfactory BOLD responses in the human brain
IntroductionIn contrast to other sensory domains, detection of primary olfactory processes using functional magnetic resonance imaging has proven to be notably challenging with conventional block designs. This difficulty arises from significant habituation and hemodynamic responses in olfactory area...
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Neuroimaging |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnimg.2023.1260893/full |
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| author | Aino-Lotta I. Alahäivälä Divesh Thaploo Simon Wein Philipp Seidel Marco Riebel Thomas Hummel Jens Volkmar Schwarzbach |
| author_facet | Aino-Lotta I. Alahäivälä Divesh Thaploo Simon Wein Philipp Seidel Marco Riebel Thomas Hummel Jens Volkmar Schwarzbach |
| author_sort | Aino-Lotta I. Alahäivälä |
| collection | DOAJ |
| description | IntroductionIn contrast to other sensory domains, detection of primary olfactory processes using functional magnetic resonance imaging has proven to be notably challenging with conventional block designs. This difficulty arises from significant habituation and hemodynamic responses in olfactory areas that do not appear to align with extended boxcar functions convolved with a generic hemodynamic response model. Consequently, some researchers have advocated for a transition to event-related designs, despite their known lower detection power compared to block designs.MethodsHere, we conducted a block design experiment with 16s of continuous odorant stimulation alternating with 16s of continuous odorless air stimulation in 33 healthy participants. We compared four statistical analyses that relied either on standard block designs (SBD1-2) or on block designs that were modulated by the participants' individual breathing patterns (MBD1-2).ResultsWe found that such modulated block designs were comparatively more powerful than standard block designs, despite having a substantially lower design efficiency. Using whole-brain effect size maps, we observed that the right insular and medial aspects of the left piriform cortex exhibited a preference for a breathing-modulated analysis approach.DiscussionResearch in olfaction that necessitates designs with longer-lasting blocks, such as those employed in the investigation of state-dependent processing, will benefit from the breathing-modulated analyses outlined in this study. |
| first_indexed | 2024-03-09T08:40:45Z |
| format | Article |
| id | doaj.art-4521038417b34c8b915b852c9b72f989 |
| institution | Directory Open Access Journal |
| issn | 2813-1193 |
| language | English |
| last_indexed | 2024-03-09T08:40:45Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroimaging |
| spelling | doaj.art-4521038417b34c8b915b852c9b72f9892023-12-02T16:59:04ZengFrontiers Media S.A.Frontiers in Neuroimaging2813-11932023-12-01210.3389/fnimg.2023.12608931260893Inhalation-modulated detection of olfactory BOLD responses in the human brainAino-Lotta I. Alahäivälä0Divesh Thaploo1Simon Wein2Philipp Seidel3Marco Riebel4Thomas Hummel5Jens Volkmar Schwarzbach6Biomedical Imaging Group, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, GermanyInterdisciplinary Center Smell and Taste, Department of Otorhinolaryngology, Technische Universität Dresden, Dresden, GermanyBiomedical Imaging Group, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, GermanyBiomedical Imaging Group, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, GermanyBiomedical Imaging Group, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, GermanyInterdisciplinary Center Smell and Taste, Department of Otorhinolaryngology, Technische Universität Dresden, Dresden, GermanyBiomedical Imaging Group, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, GermanyIntroductionIn contrast to other sensory domains, detection of primary olfactory processes using functional magnetic resonance imaging has proven to be notably challenging with conventional block designs. This difficulty arises from significant habituation and hemodynamic responses in olfactory areas that do not appear to align with extended boxcar functions convolved with a generic hemodynamic response model. Consequently, some researchers have advocated for a transition to event-related designs, despite their known lower detection power compared to block designs.MethodsHere, we conducted a block design experiment with 16s of continuous odorant stimulation alternating with 16s of continuous odorless air stimulation in 33 healthy participants. We compared four statistical analyses that relied either on standard block designs (SBD1-2) or on block designs that were modulated by the participants' individual breathing patterns (MBD1-2).ResultsWe found that such modulated block designs were comparatively more powerful than standard block designs, despite having a substantially lower design efficiency. Using whole-brain effect size maps, we observed that the right insular and medial aspects of the left piriform cortex exhibited a preference for a breathing-modulated analysis approach.DiscussionResearch in olfaction that necessitates designs with longer-lasting blocks, such as those employed in the investigation of state-dependent processing, will benefit from the breathing-modulated analyses outlined in this study.https://www.frontiersin.org/articles/10.3389/fnimg.2023.1260893/fullolfactionfunctional magnetic resonance imagingbreathing-modulated analysisdesign efficiencyblock designshabituation |
| spellingShingle | Aino-Lotta I. Alahäivälä Divesh Thaploo Simon Wein Philipp Seidel Marco Riebel Thomas Hummel Jens Volkmar Schwarzbach Inhalation-modulated detection of olfactory BOLD responses in the human brain Frontiers in Neuroimaging olfaction functional magnetic resonance imaging breathing-modulated analysis design efficiency block designs habituation |
| title | Inhalation-modulated detection of olfactory BOLD responses in the human brain |
| title_full | Inhalation-modulated detection of olfactory BOLD responses in the human brain |
| title_fullStr | Inhalation-modulated detection of olfactory BOLD responses in the human brain |
| title_full_unstemmed | Inhalation-modulated detection of olfactory BOLD responses in the human brain |
| title_short | Inhalation-modulated detection of olfactory BOLD responses in the human brain |
| title_sort | inhalation modulated detection of olfactory bold responses in the human brain |
| topic | olfaction functional magnetic resonance imaging breathing-modulated analysis design efficiency block designs habituation |
| url | https://www.frontiersin.org/articles/10.3389/fnimg.2023.1260893/full |
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