The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression
Alcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5-HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical efficacy in alcoholic individuals. Finding new pharmacological strategies that...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/2/412 |
| _version_ | 1797482397151789056 |
|---|---|
| author | Noelia Cantero-García Antonio Flores-Burgess David Ladrón de Guevara-Miranda Antonia Serrano Laura García-Durán Araceli Puigcerver Kjell Fuxe José Ángel Narváez Luis Javier Santín Zaida Díaz-Cabiale Carmelo Millón |
| author_facet | Noelia Cantero-García Antonio Flores-Burgess David Ladrón de Guevara-Miranda Antonia Serrano Laura García-Durán Araceli Puigcerver Kjell Fuxe José Ángel Narváez Luis Javier Santín Zaida Díaz-Cabiale Carmelo Millón |
| author_sort | Noelia Cantero-García |
| collection | DOAJ |
| description | Alcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5-HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical efficacy in alcoholic individuals. Finding new pharmacological strategies that could modulate alcohol consumption and depression is necessary. We have analyzed the effect of Galanin (1–15) [GAL(1–15)] on escitalopram (ESC)-mediated effect in alcohol consumption using the alcohol self-administration test, the nuclei involved in the effect, and whether GAL(1–15) + ESC modulated the response in despair or anxiety tests in animals under chronic alcohol intake. GAL(1–15) + ESC combination substantially reduced alcohol intake in the alcohol self-administration test and, moreover, enhanced the reduction of reward capacity of ESC on different reinforcers such as sucrose or saccharine. GAL(1–15) + ESC coadministration significantly decreases the number of C-Fos-IR TH cell bodies in the VTA, and PCA analysis suggests that one functional network, including VTA, RMTg and DR, is involved in these effects. Significantly in rats with chronic alcohol consumption, GAL(1–15) reversed adverse ESC-mediated effects in the depression-related behavioural test and forced swimming test. The results open up the possibility of using GAL(1–15) in combination with the SSRI Escitalopram as a novel strategy in AUD comorbidity with depression. |
| first_indexed | 2024-03-09T22:31:45Z |
| format | Article |
| id | doaj.art-4522a7ee429d4bbe9a2342bce839875b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T22:31:45Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-4522a7ee429d4bbe9a2342bce839875b2023-11-23T18:55:11ZengMDPI AGBiomedicines2227-90592022-02-0110241210.3390/biomedicines10020412The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with DepressionNoelia Cantero-García0Antonio Flores-Burgess1David Ladrón de Guevara-Miranda2Antonia Serrano3Laura García-Durán4Araceli Puigcerver5Kjell Fuxe6José Ángel Narváez7Luis Javier Santín8Zaida Díaz-Cabiale9Carmelo Millón10Facultad de Medicina, Instituto de Investigación Biomédica de Málaga, Campus de Teatinos s/n, Universidad de Málaga, 29071 Málaga, SpainFacultad de Medicina, Instituto de Investigación Biomédica de Málaga, Campus de Teatinos s/n, Universidad de Málaga, 29071 Málaga, SpainFacultad de Psicología, Instituto de Investigación Biomédica de Málaga, Campus de Teatinos s/n, Universidad de Málaga, 29071 Málaga, SpainUnidad de Gestión Clínica de Salud Mental e Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, 29010 Málaga, SpainFacultad de Medicina, Instituto de Investigación Biomédica de Málaga, Campus de Teatinos s/n, Universidad de Málaga, 29071 Málaga, SpainFacultad de Psicología, Instituto de Investigación Biomédica de Málaga, Campus de Teatinos s/n, Universidad de Málaga, 29071 Málaga, SpainDepartment of Neuroscience, Karolinska Institute, 17177 Stockholm, SwedenFacultad de Medicina, Instituto de Investigación Biomédica de Málaga, Campus de Teatinos s/n, Universidad de Málaga, 29071 Málaga, SpainFacultad de Psicología, Instituto de Investigación Biomédica de Málaga, Campus de Teatinos s/n, Universidad de Málaga, 29071 Málaga, SpainFacultad de Medicina, Instituto de Investigación Biomédica de Málaga, Campus de Teatinos s/n, Universidad de Málaga, 29071 Málaga, SpainFacultad de Medicina, Instituto de Investigación Biomédica de Málaga, Campus de Teatinos s/n, Universidad de Málaga, 29071 Málaga, SpainAlcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5-HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical efficacy in alcoholic individuals. Finding new pharmacological strategies that could modulate alcohol consumption and depression is necessary. We have analyzed the effect of Galanin (1–15) [GAL(1–15)] on escitalopram (ESC)-mediated effect in alcohol consumption using the alcohol self-administration test, the nuclei involved in the effect, and whether GAL(1–15) + ESC modulated the response in despair or anxiety tests in animals under chronic alcohol intake. GAL(1–15) + ESC combination substantially reduced alcohol intake in the alcohol self-administration test and, moreover, enhanced the reduction of reward capacity of ESC on different reinforcers such as sucrose or saccharine. GAL(1–15) + ESC coadministration significantly decreases the number of C-Fos-IR TH cell bodies in the VTA, and PCA analysis suggests that one functional network, including VTA, RMTg and DR, is involved in these effects. Significantly in rats with chronic alcohol consumption, GAL(1–15) reversed adverse ESC-mediated effects in the depression-related behavioural test and forced swimming test. The results open up the possibility of using GAL(1–15) in combination with the SSRI Escitalopram as a novel strategy in AUD comorbidity with depression.https://www.mdpi.com/2227-9059/10/2/412Galanin (1–15)escitalopramdepressionalcohol |
| spellingShingle | Noelia Cantero-García Antonio Flores-Burgess David Ladrón de Guevara-Miranda Antonia Serrano Laura García-Durán Araceli Puigcerver Kjell Fuxe José Ángel Narváez Luis Javier Santín Zaida Díaz-Cabiale Carmelo Millón The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression Biomedicines Galanin (1–15) escitalopram depression alcohol |
| title | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
| title_full | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
| title_fullStr | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
| title_full_unstemmed | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
| title_short | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
| title_sort | combination of galanin 1 15 and escitalopram in rats suggests a new strategy for alcohol use disorder comorbidity with depression |
| topic | Galanin (1–15) escitalopram depression alcohol |
| url | https://www.mdpi.com/2227-9059/10/2/412 |
| work_keys_str_mv | AT noeliacanterogarcia thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT antoniofloresburgess thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT davidladrondeguevaramiranda thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT antoniaserrano thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT lauragarciaduran thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT aracelipuigcerver thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT kjellfuxe thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT joseangelnarvaez thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT luisjaviersantin thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT zaidadiazcabiale thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT carmelomillon thecombinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT noeliacanterogarcia combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT antoniofloresburgess combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT davidladrondeguevaramiranda combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT antoniaserrano combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT lauragarciaduran combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT aracelipuigcerver combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT kjellfuxe combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT joseangelnarvaez combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT luisjaviersantin combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT zaidadiazcabiale combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression AT carmelomillon combinationofgalanin115andescitalopraminratssuggestsanewstrategyforalcoholusedisordercomorbiditywithdepression |