Colchicine modulates TIMP1, MMP1, and pMAP4 expression to enhance extracellular matrix degradation in 3T3 fibroblast-mediated myocardial infarction

Colchicine modulates TIMP1, MMP1, and pMAP4 expression to enhance extracellular matrix degradation in 3T3 fibroblast-mediated myocardial infarction

Context: Cardiovascular disease is a leading cause of mortality worldwide. Following acute myocardial infarction (AMI), cardiac cells release many cytokines and proteolytic enzymes that regulate the extracellular matrix (ECM), including matrix metalloproteinases (MMPs), tissue inhibitor of metallopr...

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Bibliographic Details
Main Authors: Saskia Dyah Handari, Mohammad Saifur Rahman, Djanggan Sargowo, Aulanni’am Aulanni’am, Bayu Lestari, Delvac Oceandy
Format: Article
Language:English
Published: GarVal Editorial Ltda. 2024-05-01
Series:Journal of Pharmacy & Pharmacognosy Research
Subjects:
cell line
colchicine
extracellular matrix
ischemia
Online Access:https://jppres.com/jppres/pdf/vol12/jppres23.1937_12.3.586.pdf

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