The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial
Abstract Objective Psoriasis is an immune-mediated inflammatory skin disease. It can involve any body skin area, particularly the scalp, lower back, elbows, and knees. There are several topical and systemic therapies for the treatment. Nowadays, herbal medicines are popular treatments for dermatolog...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-021-05667-9 |
| _version_ | 1818456596658782208 |
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| author | Alireza Yargholi Leila Shirbeigi Roja Rahimi Parvin Mansouri Mohammad Hossein Ayati |
| author_facet | Alireza Yargholi Leila Shirbeigi Roja Rahimi Parvin Mansouri Mohammad Hossein Ayati |
| author_sort | Alireza Yargholi |
| collection | DOAJ |
| description | Abstract Objective Psoriasis is an immune-mediated inflammatory skin disease. It can involve any body skin area, particularly the scalp, lower back, elbows, and knees. There are several topical and systemic therapies for the treatment. Nowadays, herbal medicines are popular treatments for dermatologic conditions. This two-arm parallel, randomized placebo-controlled clinical trial was conducted to examine the hypothesis of the efficacy of Melissa officinalis syrup on patients with mild-to-moderate Plaque psoriasis. Result Among 100 patients, 95 participants completed the trial and five of them withdrew. The mean pruritus intensity and PASI scores decreased significantly in the intervention group compared to the placebo group (P < 0.001). The DLQI score in the intervention group increased post-treatment compared to pre-treatment (P = 0.029); however, there was no significant difference between the intervention and control group at the end of the study (0.065). Trial registration: The trial was registered in the Iranian registry of clinical trials on November 9th, 2019 ( https://www.irct.ir/trial/43434 ; registration number: IRCT20191104045326N1). |
| first_indexed | 2024-12-14T22:29:11Z |
| format | Article |
| id | doaj.art-4526824a16af44718b8c52e4dc0d22f6 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-14T22:29:11Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-4526824a16af44718b8c52e4dc0d22f62022-12-21T22:45:17ZengBMCBMC Research Notes1756-05002021-06-011411610.1186/s13104-021-05667-9The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trialAlireza Yargholi0Leila Shirbeigi1Roja Rahimi2Parvin Mansouri3Mohammad Hossein Ayati4Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical SciencesDepartment of Persian Medicine, School of Persian Medicine, Tehran University of Medical SciencesDepartment of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical SciencesDepartment of Dermatology, Faculty of Medicine, Tehran University of Medical SciencesDepartment of Persian Medicine, School of Persian Medicine, Tehran University of Medical SciencesAbstract Objective Psoriasis is an immune-mediated inflammatory skin disease. It can involve any body skin area, particularly the scalp, lower back, elbows, and knees. There are several topical and systemic therapies for the treatment. Nowadays, herbal medicines are popular treatments for dermatologic conditions. This two-arm parallel, randomized placebo-controlled clinical trial was conducted to examine the hypothesis of the efficacy of Melissa officinalis syrup on patients with mild-to-moderate Plaque psoriasis. Result Among 100 patients, 95 participants completed the trial and five of them withdrew. The mean pruritus intensity and PASI scores decreased significantly in the intervention group compared to the placebo group (P < 0.001). The DLQI score in the intervention group increased post-treatment compared to pre-treatment (P = 0.029); however, there was no significant difference between the intervention and control group at the end of the study (0.065). Trial registration: The trial was registered in the Iranian registry of clinical trials on November 9th, 2019 ( https://www.irct.ir/trial/43434 ; registration number: IRCT20191104045326N1).https://doi.org/10.1186/s13104-021-05667-9PsoriasisQuality of lifePruritusMelissa officinalis syrup |
| spellingShingle | Alireza Yargholi Leila Shirbeigi Roja Rahimi Parvin Mansouri Mohammad Hossein Ayati The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial BMC Research Notes Psoriasis Quality of life Pruritus Melissa officinalis syrup |
| title | The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial |
| title_full | The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial |
| title_fullStr | The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial |
| title_full_unstemmed | The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial |
| title_short | The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial |
| title_sort | effect of melissa officinalis syrup on patients with mild to moderate psoriasis a randomized double blind placebo controlled clinical trial |
| topic | Psoriasis Quality of life Pruritus Melissa officinalis syrup |
| url | https://doi.org/10.1186/s13104-021-05667-9 |
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