The metabolic syndrome as a risk factor for colorectal cancer
Objective. To evaluate the prognostic significance of metabolic syndrome (MS) in the development of colorectal cancer (CRC) using various MS criteria in Novosibirsk population. Materials and Methods. The study was designed as nested «case-control». Baseline population cohort (936...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2017-09-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/8178 |
| _version_ | 1797204595737362432 |
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| author | Tatiana M. Nikitenko Lilia V. Shcherbakova Sofia K. Malyutina Svetlana V. Mustafina Eugene G. Verevkin Yuliya I. Ragino Vladimir E. Voytsitsky Anna V. Pyatibratova Oksana D. Rymar |
| author_facet | Tatiana M. Nikitenko Lilia V. Shcherbakova Sofia K. Malyutina Svetlana V. Mustafina Eugene G. Verevkin Yuliya I. Ragino Vladimir E. Voytsitsky Anna V. Pyatibratova Oksana D. Rymar |
| author_sort | Tatiana M. Nikitenko |
| collection | DOAJ |
| description | Objective. To evaluate the prognostic significance of metabolic syndrome (MS) in the development of colorectal cancer (CRC) using various MS criteria in Novosibirsk population. Materials and Methods. The study was designed as nested «case-control». Baseline population cohort (9360 men, women aged 45–69) was examined in the HAPIEE project and followed-up during 11 years. The “cases” included all subjects, who had CRC during 11-year follow-up according to the Register of Cancer (n=99, M-52, M-47). The matched control group (2/1) was selected from HAPIEE cohort (n=198, m-104, w-94). The prospective study of CRC was supported by RSF. MS criteria were determined in accordance to VNOK (2009), IDF (2005), NCEP ATP III (2001). Statistical package SPSS v.11.0 was used. Logistic regression was used to estimate the association between MS and risk of CRC. Results. Women with glucose levels ≥6.1 mmol/l had 3 times higher 11-year risk of CRC then those with glucose <6.1 mmol/l (OR=3.11; 95%CI:1.23–7.87, VNOK, 2009; OR=3.20; 95%CI:1.27–8.08, NCEP ATP III, 2001). Blood pressure (BP) ≥130/85 mmHg was associated with decreased risk of CRC in women and in both sexes, but the relationship became insignificant after controlling for antihypertensive treatment. Other components of the MS were not significantly associated with CRC risk. Conclusions. In studied sample the 11-year risk of developing CRC was significantly increased in women with elevated glucose levels. The negative relationship between elevated BP and the risk of CRC in women and both sexes became insignificant when adjusted for antihypertensive treatment; this finding requires further exploration. |
| first_indexed | 2024-03-08T09:13:05Z |
| format | Article |
| id | doaj.art-45286815667f424dac1fc7ec7cc3aaf9 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:37:44Z |
| publishDate | 2017-09-01 |
| publisher | Endocrinology Research Centre |
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| series | Ожирение и метаболизм |
| spelling | doaj.art-45286815667f424dac1fc7ec7cc3aaf92024-04-16T16:16:10ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242017-09-01142243210.14341/omet2017224-327602The metabolic syndrome as a risk factor for colorectal cancerTatiana M. Nikitenko0Lilia V. Shcherbakova1Sofia K. Malyutina2Svetlana V. Mustafina3Eugene G. Verevkin4Yuliya I. Ragino5Vladimir E. Voytsitsky6Anna V. Pyatibratova7Oksana D. Rymar8<p>‘‘Institution of Internal and Preventive Medicine”</p><p>‘‘Institution of Internal and Preventive Medicine”</p><p>‘‘Institution of Internal and Preventive Medicine”</p><p>‘‘Institution of Internal and Preventive Medicine”</p><p>«Institution of Internal and Preventive Medicine»; The Institute of Molecular Biology and Biophysics</p><p>«Institution of Internal and Preventive Medicine»</p><p>«Novosibirsk Regional Clinical Oncology Center»</p><p>«Novosibirsk Regional Clinical Oncology Center»</p><p>«Institution of Internal and Preventive Medicine»</p>Objective. To evaluate the prognostic significance of metabolic syndrome (MS) in the development of colorectal cancer (CRC) using various MS criteria in Novosibirsk population. Materials and Methods. The study was designed as nested «case-control». Baseline population cohort (9360 men, women aged 45–69) was examined in the HAPIEE project and followed-up during 11 years. The “cases” included all subjects, who had CRC during 11-year follow-up according to the Register of Cancer (n=99, M-52, M-47). The matched control group (2/1) was selected from HAPIEE cohort (n=198, m-104, w-94). The prospective study of CRC was supported by RSF. MS criteria were determined in accordance to VNOK (2009), IDF (2005), NCEP ATP III (2001). Statistical package SPSS v.11.0 was used. Logistic regression was used to estimate the association between MS and risk of CRC. Results. Women with glucose levels ≥6.1 mmol/l had 3 times higher 11-year risk of CRC then those with glucose <6.1 mmol/l (OR=3.11; 95%CI:1.23–7.87, VNOK, 2009; OR=3.20; 95%CI:1.27–8.08, NCEP ATP III, 2001). Blood pressure (BP) ≥130/85 mmHg was associated with decreased risk of CRC in women and in both sexes, but the relationship became insignificant after controlling for antihypertensive treatment. Other components of the MS were not significantly associated with CRC risk. Conclusions. In studied sample the 11-year risk of developing CRC was significantly increased in women with elevated glucose levels. The negative relationship between elevated BP and the risk of CRC in women and both sexes became insignificant when adjusted for antihypertensive treatment; this finding requires further exploration.https://www.omet-endojournals.ru/jour/article/view/8178metabolic syndromecolorectal cancerthe components of the metabolic syndromecolon and rectum cancer |
| spellingShingle | Tatiana M. Nikitenko Lilia V. Shcherbakova Sofia K. Malyutina Svetlana V. Mustafina Eugene G. Verevkin Yuliya I. Ragino Vladimir E. Voytsitsky Anna V. Pyatibratova Oksana D. Rymar The metabolic syndrome as a risk factor for colorectal cancer Ожирение и метаболизм metabolic syndrome colorectal cancer the components of the metabolic syndrome colon and rectum cancer |
| title | The metabolic syndrome as a risk factor for colorectal cancer |
| title_full | The metabolic syndrome as a risk factor for colorectal cancer |
| title_fullStr | The metabolic syndrome as a risk factor for colorectal cancer |
| title_full_unstemmed | The metabolic syndrome as a risk factor for colorectal cancer |
| title_short | The metabolic syndrome as a risk factor for colorectal cancer |
| title_sort | metabolic syndrome as a risk factor for colorectal cancer |
| topic | metabolic syndrome colorectal cancer the components of the metabolic syndrome colon and rectum cancer |
| url | https://www.omet-endojournals.ru/jour/article/view/8178 |
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