Protective Effects of Epigallocatechin-3-gallate (EGCG) against the Jellyfish <i>Nemopilema nomurai</i> Envenoming
Jellyfish stings are the most common marine animal injuries worldwide, with approximately 150 million envenomation cases annually, and the victims may suffer from severe pain, itching, swelling, inflammation, arrhythmias, cardiac failure, or even death. Consequently, identification of effective firs...
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MDPI AG
2023-04-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/15/4/283 |
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| author | Jie Li Qianqian Wang Shuaijun Zou Juxingsi Song Peipei Zhang Fan Wang Yichao Huang Qian He Liming Zhang |
| author_facet | Jie Li Qianqian Wang Shuaijun Zou Juxingsi Song Peipei Zhang Fan Wang Yichao Huang Qian He Liming Zhang |
| author_sort | Jie Li |
| collection | DOAJ |
| description | Jellyfish stings are the most common marine animal injuries worldwide, with approximately 150 million envenomation cases annually, and the victims may suffer from severe pain, itching, swelling, inflammation, arrhythmias, cardiac failure, or even death. Consequently, identification of effective first aid reagents for jellyfish envenoming is urgently needed. Here, we found that the polyphenol epigallocatechin-3-gallate (EGCG) markedly antagonized the hemolytic toxicity, proteolytic activity, and cardiomyocyte toxicity of the jellyfish <i>Nemopilema nomurai</i> venom in vitro and could prevent and treat systemic envenoming caused by <i>N. nomurai</i> venom in vivo. Moreover, EGCG is a natural plant active ingredient and widely used as a food additive without toxic side effects. Hence, we suppose that EGCG might be an effective antagonist against systemic envenoming induced by jellyfish venom. |
| first_indexed | 2024-03-11T04:27:57Z |
| format | Article |
| id | doaj.art-452a6ad8ab0a4258bb97952e467c3b63 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-11T04:27:57Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
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| series | Toxins |
| spelling | doaj.art-452a6ad8ab0a4258bb97952e467c3b632023-11-17T21:39:00ZengMDPI AGToxins2072-66512023-04-0115428310.3390/toxins15040283Protective Effects of Epigallocatechin-3-gallate (EGCG) against the Jellyfish <i>Nemopilema nomurai</i> EnvenomingJie Li0Qianqian Wang1Shuaijun Zou2Juxingsi Song3Peipei Zhang4Fan Wang5Yichao Huang6Qian He7Liming Zhang8Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, ChinaDepartment of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, ChinaDepartment of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, ChinaDepartment of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, ChinaDepartment of Marine Biological Injury and Dermatology, Naval Special Medical Center, Naval Medical University, Shanghai 200052, ChinaDepartment of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, ChinaDepartment of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, ChinaThe Third Affiliated Hospital, Naval Medical University, Shanghai 200433, ChinaDepartment of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, ChinaJellyfish stings are the most common marine animal injuries worldwide, with approximately 150 million envenomation cases annually, and the victims may suffer from severe pain, itching, swelling, inflammation, arrhythmias, cardiac failure, or even death. Consequently, identification of effective first aid reagents for jellyfish envenoming is urgently needed. Here, we found that the polyphenol epigallocatechin-3-gallate (EGCG) markedly antagonized the hemolytic toxicity, proteolytic activity, and cardiomyocyte toxicity of the jellyfish <i>Nemopilema nomurai</i> venom in vitro and could prevent and treat systemic envenoming caused by <i>N. nomurai</i> venom in vivo. Moreover, EGCG is a natural plant active ingredient and widely used as a food additive without toxic side effects. Hence, we suppose that EGCG might be an effective antagonist against systemic envenoming induced by jellyfish venom.https://www.mdpi.com/2072-6651/15/4/283epigallocatechin-3-gallate (EGCG)jellyfish venomhemolytic toxicityproteolytic activitycardiomyocyte toxicity |
| spellingShingle | Jie Li Qianqian Wang Shuaijun Zou Juxingsi Song Peipei Zhang Fan Wang Yichao Huang Qian He Liming Zhang Protective Effects of Epigallocatechin-3-gallate (EGCG) against the Jellyfish <i>Nemopilema nomurai</i> Envenoming Toxins epigallocatechin-3-gallate (EGCG) jellyfish venom hemolytic toxicity proteolytic activity cardiomyocyte toxicity |
| title | Protective Effects of Epigallocatechin-3-gallate (EGCG) against the Jellyfish <i>Nemopilema nomurai</i> Envenoming |
| title_full | Protective Effects of Epigallocatechin-3-gallate (EGCG) against the Jellyfish <i>Nemopilema nomurai</i> Envenoming |
| title_fullStr | Protective Effects of Epigallocatechin-3-gallate (EGCG) against the Jellyfish <i>Nemopilema nomurai</i> Envenoming |
| title_full_unstemmed | Protective Effects of Epigallocatechin-3-gallate (EGCG) against the Jellyfish <i>Nemopilema nomurai</i> Envenoming |
| title_short | Protective Effects of Epigallocatechin-3-gallate (EGCG) against the Jellyfish <i>Nemopilema nomurai</i> Envenoming |
| title_sort | protective effects of epigallocatechin 3 gallate egcg against the jellyfish i nemopilema nomurai i envenoming |
| topic | epigallocatechin-3-gallate (EGCG) jellyfish venom hemolytic toxicity proteolytic activity cardiomyocyte toxicity |
| url | https://www.mdpi.com/2072-6651/15/4/283 |
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