Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study
(1) Background: The relationship between lipids, apolipoproteins, and telomere length (TL) has been explored in previous studies; however, the causal relationship between the two remains unclear. This study aims to assess the causal relationship between lipids, apolipoproteins, and TL using the two-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/21/4497 |
| _version_ | 1797631484114239488 |
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| author | Gehua Zhu Jiamin Xu Guanghua Guo Feng Zhu |
| author_facet | Gehua Zhu Jiamin Xu Guanghua Guo Feng Zhu |
| author_sort | Gehua Zhu |
| collection | DOAJ |
| description | (1) Background: The relationship between lipids, apolipoproteins, and telomere length (TL) has been explored in previous studies; however, the causal relationship between the two remains unclear. This study aims to assess the causal relationship between lipids, apolipoproteins, and TL using the two-sample Mendelian randomization (MR) approach; (2) Methods: This study comprehensively employed both univariate MR (uvMR) and multivariate MR (mvMR) methods to genetically evaluate the associations between 21 exposures related to lipids and apolipoproteins and the outcome of TL. During the analysis process, we utilized various statistical methods, including Inverse Variance Weighting (IVW), Weighted Median, MR-Egger regression, MR-PRESSO, and outlier tests. Furthermore, to confirm the robustness of the results, we conducted several sensitivity analyses to explore potential heterogeneity; (3) Results: The uvMR analysis indicated that an increase in MUFA, MUFA/FA ratio, LDL-C, VLDL-C, total cholesterol, ApoB, and triglycerides (TG) was associated with an increase in TL. However, this relationship did not manifest in the mvMR analysis, suggesting that this association may be based on preliminary evidence; (4) Conclusions: MR analysis results suggest potential suggestive positive causal relationships between genetically predicted MUFA, MUFA/FA ratio, LDL-C, VLDL-C, total cholesterol, ApoB, and TG with TL. |
| first_indexed | 2024-03-11T11:24:09Z |
| format | Article |
| id | doaj.art-452c8004565143b2b88987f109e51c4d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T11:24:09Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-452c8004565143b2b88987f109e51c4d2023-11-10T15:09:24ZengMDPI AGNutrients2072-66432023-10-011521449710.3390/nu15214497Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization StudyGehua Zhu0Jiamin Xu1Guanghua Guo2Feng Zhu3Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaDepartment of Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China(1) Background: The relationship between lipids, apolipoproteins, and telomere length (TL) has been explored in previous studies; however, the causal relationship between the two remains unclear. This study aims to assess the causal relationship between lipids, apolipoproteins, and TL using the two-sample Mendelian randomization (MR) approach; (2) Methods: This study comprehensively employed both univariate MR (uvMR) and multivariate MR (mvMR) methods to genetically evaluate the associations between 21 exposures related to lipids and apolipoproteins and the outcome of TL. During the analysis process, we utilized various statistical methods, including Inverse Variance Weighting (IVW), Weighted Median, MR-Egger regression, MR-PRESSO, and outlier tests. Furthermore, to confirm the robustness of the results, we conducted several sensitivity analyses to explore potential heterogeneity; (3) Results: The uvMR analysis indicated that an increase in MUFA, MUFA/FA ratio, LDL-C, VLDL-C, total cholesterol, ApoB, and triglycerides (TG) was associated with an increase in TL. However, this relationship did not manifest in the mvMR analysis, suggesting that this association may be based on preliminary evidence; (4) Conclusions: MR analysis results suggest potential suggestive positive causal relationships between genetically predicted MUFA, MUFA/FA ratio, LDL-C, VLDL-C, total cholesterol, ApoB, and TG with TL.https://www.mdpi.com/2072-6643/15/21/4497lipidsapolipoproteinstelomere lengthmendelian randomization |
| spellingShingle | Gehua Zhu Jiamin Xu Guanghua Guo Feng Zhu Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study Nutrients lipids apolipoproteins telomere length mendelian randomization |
| title | Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study |
| title_full | Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study |
| title_fullStr | Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study |
| title_full_unstemmed | Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study |
| title_short | Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study |
| title_sort | association between lipids apolipoproteins and telomere length a mendelian randomization study |
| topic | lipids apolipoproteins telomere length mendelian randomization |
| url | https://www.mdpi.com/2072-6643/15/21/4497 |
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