Serum C - Reactive Protein Level in Diabetic Foot Patients and Their Relation with Bacterial Isolates
Background: Foot infections are one of the major complications of diabetes mellitus and a significant risk factor for lower extremity amputation. C-reactive protein is an acute-phase reactant, rises dramatically in response to infection. Aim: To determine the microbial isolates of patients wit...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2019-11-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/438 |
| _version_ | 1797454757997051904 |
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| author | Shler G Raheem Ruqaya M Al- Barzinji Ali A Al-Dabbagh |
| author_facet | Shler G Raheem Ruqaya M Al- Barzinji Ali A Al-Dabbagh |
| author_sort | Shler G Raheem |
| collection | DOAJ |
| description |
Background: Foot infections are one of the major complications of diabetes mellitus and a significant risk factor for lower extremity amputation. C-reactive protein is an acute-phase reactant, rises dramatically in response to infection.
Aim: To determine the microbial isolates of patients with diabetic foot infections and their relation with C-reactive protein level in their sera.
Materials and Methods: A prospective study of 90 patients with diabetic foot infections admitted to different public and private hospitals in Erbil city center-Iraq between June 2011 and May 2012 was undertaken. Bacteriological specimens were obtained and processed using standard procedure. The patients serum had been tested for C-reactive protein by high sensitive Enzyme linked Immunosorbent Assay (ELISA).
Results: A total of 130 pathogens were isolated from 90 diabetic foot patients 46 (51%) of the patients had polymicrobial infection, 37 (41%) had single organism and 7 (8%) had no growth. Gram positive (G+ve) bacteria 60(53%) were more commonly isolated than Gram negative (G-ve) bacteria 53(47%). Staphylococcus aureus and Escherichia coli were the most frequently among G+ve and G-ve isolates respectively. No significant difference was found between mean serum levels of C-reactive protein in patients infected with G+ve bacteria versus G-ve bacteria, although their concentration was more in the later. However, highly significant differences (P<0.01) were observed between both G+ve and G-ve bacteria versus no bacterial isolate in patients.
Conclusion: C-reactive protein serum level was higher in patient with diabetic foot infected by G-ve bacteria, although G+ve bacteria represented a major bacterial isolates.
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| first_indexed | 2024-03-09T15:42:43Z |
| format | Article |
| id | doaj.art-452cefd87545481a8e1ac11896a4b813 |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:42:43Z |
| publishDate | 2019-11-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-452cefd87545481a8e1ac11896a4b8132023-11-24T23:23:31ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-11-0131Serum C - Reactive Protein Level in Diabetic Foot Patients and Their Relation with Bacterial IsolatesShler G Raheem Ruqaya M Al- Barzinji Ali A Al-Dabbagh Background: Foot infections are one of the major complications of diabetes mellitus and a significant risk factor for lower extremity amputation. C-reactive protein is an acute-phase reactant, rises dramatically in response to infection. Aim: To determine the microbial isolates of patients with diabetic foot infections and their relation with C-reactive protein level in their sera. Materials and Methods: A prospective study of 90 patients with diabetic foot infections admitted to different public and private hospitals in Erbil city center-Iraq between June 2011 and May 2012 was undertaken. Bacteriological specimens were obtained and processed using standard procedure. The patients serum had been tested for C-reactive protein by high sensitive Enzyme linked Immunosorbent Assay (ELISA). Results: A total of 130 pathogens were isolated from 90 diabetic foot patients 46 (51%) of the patients had polymicrobial infection, 37 (41%) had single organism and 7 (8%) had no growth. Gram positive (G+ve) bacteria 60(53%) were more commonly isolated than Gram negative (G-ve) bacteria 53(47%). Staphylococcus aureus and Escherichia coli were the most frequently among G+ve and G-ve isolates respectively. No significant difference was found between mean serum levels of C-reactive protein in patients infected with G+ve bacteria versus G-ve bacteria, although their concentration was more in the later. However, highly significant differences (P<0.01) were observed between both G+ve and G-ve bacteria versus no bacterial isolate in patients. Conclusion: C-reactive protein serum level was higher in patient with diabetic foot infected by G-ve bacteria, although G+ve bacteria represented a major bacterial isolates. http://djm.uodiyala.edu.iq/index.php/djm/article/view/438Diabetic Foot; Infection; Microorganism; C-reactive protein |
| spellingShingle | Shler G Raheem Ruqaya M Al- Barzinji Ali A Al-Dabbagh Serum C - Reactive Protein Level in Diabetic Foot Patients and Their Relation with Bacterial Isolates Diyala Journal of Medicine Diabetic Foot; Infection; Microorganism; C-reactive protein |
| title | Serum C - Reactive Protein Level in Diabetic Foot Patients and Their Relation with Bacterial Isolates |
| title_full | Serum C - Reactive Protein Level in Diabetic Foot Patients and Their Relation with Bacterial Isolates |
| title_fullStr | Serum C - Reactive Protein Level in Diabetic Foot Patients and Their Relation with Bacterial Isolates |
| title_full_unstemmed | Serum C - Reactive Protein Level in Diabetic Foot Patients and Their Relation with Bacterial Isolates |
| title_short | Serum C - Reactive Protein Level in Diabetic Foot Patients and Their Relation with Bacterial Isolates |
| title_sort | serum c reactive protein level in diabetic foot patients and their relation with bacterial isolates |
| topic | Diabetic Foot; Infection; Microorganism; C-reactive protein |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/438 |
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