Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic Plaque
Background: Previous studies have indicated that white blood cells (WBCs) might contribute to the development of atherosclerosis. However, the associations of WBCs and WBC subgroups with carotid atherosclerotic plaque (CAP) have not been compared.Methods: A cross-sectional study including 3,569 heal...
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2020.00313/full |
| _version_ | 1818517428029620224 |
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| author | Yanhua Liu Yongjian Zhu Wenrui Jia Dan Sun Li Zhao Chen Zhang Cuicui Wang Quanjun Lyu Yuming Chen Gaiyun Chen Yacong Bo Yurong Xing |
| author_facet | Yanhua Liu Yongjian Zhu Wenrui Jia Dan Sun Li Zhao Chen Zhang Cuicui Wang Quanjun Lyu Yuming Chen Gaiyun Chen Yacong Bo Yurong Xing |
| author_sort | Yanhua Liu |
| collection | DOAJ |
| description | Background: Previous studies have indicated that white blood cells (WBCs) might contribute to the development of atherosclerosis. However, the associations of WBCs and WBC subgroups with carotid atherosclerotic plaque (CAP) have not been compared.Methods: A cross-sectional study including 3,569 healthy Chinese adults was conducted between January 2016 and December 2018 in Zhengzhou, China, to explore the associations of WBC and WBC subtypes with the presence, severity, and types of CAPs. Fasting peripheral venous blood was collected for measurement of the total WBC and WBC subtype counts. The size, composition, and types of CAPs in the common carotid artery, the internal carotid artery, and the external carotid artery were measured bilaterally using B-mode ultrasound.Results: The total WBC, neutrophil, and monocyte counts showed significant associations with the presence of CAPs in men, but not in women, with the adjusted odds ratios (95% CI) in the highest (compared to the lowest) quartile 1.99 (1.33–2.97), 1.65 (1.10–2.47), and 2.17 (1.41–3.18) (Ptrend = 0.004, Ptrend = 0.004, and Ptrend < 0.001), respectively. The three leukocyte counts were also significantly associated with the severity of CAPs, as judged by the count of CAPs, maximal internal carotid plaque thickness, and the plaque score (all P < 0.01, Ptrend < 0.05). Compared with individuals without CAPs, those with echolucent plaques had significantly increased total WBC and neutrophil counts, whereas those with polytype plaques had a significantly increased monocyte count.Conclusion: WBC, neutrophil, and monocyte counts were significantly associated with the presence, severity, and types of CAPs in a healthy Chinese population. |
| first_indexed | 2024-12-11T00:56:09Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T00:56:09Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-452e062479714661a1995ebba91d2ae52022-12-22T01:26:29ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-07-01710.3389/fmed.2020.00313543583Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic PlaqueYanhua Liu0Yongjian Zhu1Wenrui Jia2Dan Sun3Li Zhao4Chen Zhang5Cuicui Wang6Quanjun Lyu7Yuming Chen8Gaiyun Chen9Yacong Bo10Yurong Xing11Department of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Physical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Physical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Physical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Physical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Physical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, ChinaDepartment of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Physical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaBackground: Previous studies have indicated that white blood cells (WBCs) might contribute to the development of atherosclerosis. However, the associations of WBCs and WBC subgroups with carotid atherosclerotic plaque (CAP) have not been compared.Methods: A cross-sectional study including 3,569 healthy Chinese adults was conducted between January 2016 and December 2018 in Zhengzhou, China, to explore the associations of WBC and WBC subtypes with the presence, severity, and types of CAPs. Fasting peripheral venous blood was collected for measurement of the total WBC and WBC subtype counts. The size, composition, and types of CAPs in the common carotid artery, the internal carotid artery, and the external carotid artery were measured bilaterally using B-mode ultrasound.Results: The total WBC, neutrophil, and monocyte counts showed significant associations with the presence of CAPs in men, but not in women, with the adjusted odds ratios (95% CI) in the highest (compared to the lowest) quartile 1.99 (1.33–2.97), 1.65 (1.10–2.47), and 2.17 (1.41–3.18) (Ptrend = 0.004, Ptrend = 0.004, and Ptrend < 0.001), respectively. The three leukocyte counts were also significantly associated with the severity of CAPs, as judged by the count of CAPs, maximal internal carotid plaque thickness, and the plaque score (all P < 0.01, Ptrend < 0.05). Compared with individuals without CAPs, those with echolucent plaques had significantly increased total WBC and neutrophil counts, whereas those with polytype plaques had a significantly increased monocyte count.Conclusion: WBC, neutrophil, and monocyte counts were significantly associated with the presence, severity, and types of CAPs in a healthy Chinese population.https://www.frontiersin.org/article/10.3389/fmed.2020.00313/fullatherosclerosiscarotid atherosclerotic plaquewhite blood cell countneutrophilsmonocytes |
| spellingShingle | Yanhua Liu Yongjian Zhu Wenrui Jia Dan Sun Li Zhao Chen Zhang Cuicui Wang Quanjun Lyu Yuming Chen Gaiyun Chen Yacong Bo Yurong Xing Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic Plaque Frontiers in Medicine atherosclerosis carotid atherosclerotic plaque white blood cell count neutrophils monocytes |
| title | Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic Plaque |
| title_full | Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic Plaque |
| title_fullStr | Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic Plaque |
| title_full_unstemmed | Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic Plaque |
| title_short | Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic Plaque |
| title_sort | association of the total white blood cell neutrophils and monocytes count with the presence severity and types of carotid atherosclerotic plaque |
| topic | atherosclerosis carotid atherosclerotic plaque white blood cell count neutrophils monocytes |
| url | https://www.frontiersin.org/article/10.3389/fmed.2020.00313/full |
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