Membrane Contact Sites in Autophagy
Eukaryotes utilize different communication strategies to coordinate processes between different cellular compartments either indirectly, through vesicular transport, or directly, via membrane contact sites (MCSs). MCSs have been implicated in lipid metabolism, calcium signaling and the regulation of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/23/3813 |
| _version_ | 1827643280124280832 |
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| author | Emma Zwilling Fulvio Reggiori |
| author_facet | Emma Zwilling Fulvio Reggiori |
| author_sort | Emma Zwilling |
| collection | DOAJ |
| description | Eukaryotes utilize different communication strategies to coordinate processes between different cellular compartments either indirectly, through vesicular transport, or directly, via membrane contact sites (MCSs). MCSs have been implicated in lipid metabolism, calcium signaling and the regulation of organelle biogenesis in various cell types. Several studies have shown that MCSs play a crucial role in the regulation of macroautophagy, an intracellular catabolic transport route that is characterized by the delivery of cargoes (proteins, protein complexes or aggregates, organelles and pathogens) to yeast and plant vacuoles or mammalian lysosomes, for their degradation and recycling into basic metabolites. Macroautophagy is characterized by the de novo formation of double-membrane vesicles called autophagosomes, and their biogenesis requires an enormous amount of lipids. MCSs appear to have a central role in this supply, as well as in the organization of the autophagy-related (ATG) machinery. In this review, we will summarize the evidence for the participation of specific MCSs in autophagosome formation, with a focus on the budding yeast and mammalian systems. |
| first_indexed | 2024-03-09T17:51:15Z |
| format | Article |
| id | doaj.art-452e63b1396b4496a3da9903557c1ecd |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:51:15Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-452e63b1396b4496a3da9903557c1ecd2023-11-24T10:44:13ZengMDPI AGCells2073-44092022-11-011123381310.3390/cells11233813Membrane Contact Sites in AutophagyEmma Zwilling0Fulvio Reggiori1Department of Biomedicine, Aarhus University, Ole Worms Allé 4, 8000C Aarhus, DenmarkDepartment of Biomedicine, Aarhus University, Ole Worms Allé 4, 8000C Aarhus, DenmarkEukaryotes utilize different communication strategies to coordinate processes between different cellular compartments either indirectly, through vesicular transport, or directly, via membrane contact sites (MCSs). MCSs have been implicated in lipid metabolism, calcium signaling and the regulation of organelle biogenesis in various cell types. Several studies have shown that MCSs play a crucial role in the regulation of macroautophagy, an intracellular catabolic transport route that is characterized by the delivery of cargoes (proteins, protein complexes or aggregates, organelles and pathogens) to yeast and plant vacuoles or mammalian lysosomes, for their degradation and recycling into basic metabolites. Macroautophagy is characterized by the de novo formation of double-membrane vesicles called autophagosomes, and their biogenesis requires an enormous amount of lipids. MCSs appear to have a central role in this supply, as well as in the organization of the autophagy-related (ATG) machinery. In this review, we will summarize the evidence for the participation of specific MCSs in autophagosome formation, with a focus on the budding yeast and mammalian systems.https://www.mdpi.com/2073-4409/11/23/3813phagophoreautophagosomeendoplasmic reticulummitochondriaMAMsplasma membrane |
| spellingShingle | Emma Zwilling Fulvio Reggiori Membrane Contact Sites in Autophagy Cells phagophore autophagosome endoplasmic reticulum mitochondria MAMs plasma membrane |
| title | Membrane Contact Sites in Autophagy |
| title_full | Membrane Contact Sites in Autophagy |
| title_fullStr | Membrane Contact Sites in Autophagy |
| title_full_unstemmed | Membrane Contact Sites in Autophagy |
| title_short | Membrane Contact Sites in Autophagy |
| title_sort | membrane contact sites in autophagy |
| topic | phagophore autophagosome endoplasmic reticulum mitochondria MAMs plasma membrane |
| url | https://www.mdpi.com/2073-4409/11/23/3813 |
| work_keys_str_mv | AT emmazwilling membranecontactsitesinautophagy AT fulvioreggiori membranecontactsitesinautophagy |