Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction
Abstract Air pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-09383-7 |
| _version_ | 1811272202822090752 |
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| author | Alberto Cecconi Gonzalo Navarrete Marcos Garcia-Guimaraes Alberto Vera Rafael Blanco-Dominguez Ancor Sanz-Garcia Marta Lozano-Prieto Beatriz Lopez-Melgar Fernando Rivero Pilar Martin Francisco Sanchez-Madrid Hortensia de la Fuente Luis Jesus Jimenez-Borreguero Fernando Alfonso |
| author_facet | Alberto Cecconi Gonzalo Navarrete Marcos Garcia-Guimaraes Alberto Vera Rafael Blanco-Dominguez Ancor Sanz-Garcia Marta Lozano-Prieto Beatriz Lopez-Melgar Fernando Rivero Pilar Martin Francisco Sanchez-Madrid Hortensia de la Fuente Luis Jesus Jimenez-Borreguero Fernando Alfonso |
| author_sort | Alberto Cecconi |
| collection | DOAJ |
| description | Abstract Air pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes and 57 controls with stable angina. For each patient, air pollution exposure in the 24-h before admission, was collected. All patients underwent systematic circulating inflammatory cell analyses. According to PM2.5 exposure, 31 patients were selected for microRNA analyses. STEMI patients exposed to PM2.5 showed a reduction of CD4+ regulatory T cells. Furthermore, in STEMI patients the exposure to PM2.5 was associated with an increase of miR-146a-5p and miR-423-3p. In STEMI and NSTEMI patients PM2.5 exposure was associated with an increase of miR-let-7f-5p. STEMI related to PM2.5 short-term exposure is associated with changes involving regulatory T cells, miR-146a-5p and miR-423-3p. |
| first_indexed | 2024-04-12T22:34:42Z |
| format | Article |
| id | doaj.art-452fe53a79fd404fb5d7050446718b3a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T22:34:42Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-452fe53a79fd404fb5d7050446718b3a2022-12-22T03:13:52ZengNature PortfolioScientific Reports2045-23222022-03-0112111210.1038/s41598-022-09383-7Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarctionAlberto Cecconi0Gonzalo Navarrete1Marcos Garcia-Guimaraes2Alberto Vera3Rafael Blanco-Dominguez4Ancor Sanz-Garcia5Marta Lozano-Prieto6Beatriz Lopez-Melgar7Fernando Rivero8Pilar Martin9Francisco Sanchez-Madrid10Hortensia de la Fuente11Luis Jesus Jimenez-Borreguero12Fernando Alfonso13Department of Cardiology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Department of Cardiology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Department of Cardiology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Department of Cardiology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Vascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC)Data Analysis Unit, Instituto de Investigación Sanitaria, Hospital Universitario de La PrincesaDepartment of Immunology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Department of Cardiology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Department of Cardiology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Vascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC)Vascular Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC)Department of Immunology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Department of Cardiology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Department of Cardiology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IISP)Abstract Air pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes and 57 controls with stable angina. For each patient, air pollution exposure in the 24-h before admission, was collected. All patients underwent systematic circulating inflammatory cell analyses. According to PM2.5 exposure, 31 patients were selected for microRNA analyses. STEMI patients exposed to PM2.5 showed a reduction of CD4+ regulatory T cells. Furthermore, in STEMI patients the exposure to PM2.5 was associated with an increase of miR-146a-5p and miR-423-3p. In STEMI and NSTEMI patients PM2.5 exposure was associated with an increase of miR-let-7f-5p. STEMI related to PM2.5 short-term exposure is associated with changes involving regulatory T cells, miR-146a-5p and miR-423-3p.https://doi.org/10.1038/s41598-022-09383-7 |
| spellingShingle | Alberto Cecconi Gonzalo Navarrete Marcos Garcia-Guimaraes Alberto Vera Rafael Blanco-Dominguez Ancor Sanz-Garcia Marta Lozano-Prieto Beatriz Lopez-Melgar Fernando Rivero Pilar Martin Francisco Sanchez-Madrid Hortensia de la Fuente Luis Jesus Jimenez-Borreguero Fernando Alfonso Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction Scientific Reports |
| title | Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction |
| title_full | Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction |
| title_fullStr | Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction |
| title_full_unstemmed | Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction |
| title_short | Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction |
| title_sort | influence of air pollutants on circulating inflammatory cells and microrna expression in acute myocardial infarction |
| url | https://doi.org/10.1038/s41598-022-09383-7 |
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