Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function
Silica nanofibers were prepared by electrospinning technique, and then a sodium alginate coated three-dimensional silica hemostatic sponge (ALG/SiO<sub>2</sub>/Ca<sup>2+</sup> sponge) was obtained by freeze-drying method and Ca<sup>2+</sup> crosslinking. The struc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Journal of Materials Engineering
2019-12-01
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| Series: | Cailiao gongcheng |
| Subjects: | |
| Online Access: | http://jme.biam.ac.cn/CN/Y2019/V47/I12/124 |
| _version_ | 1797964813959168000 |
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| author | SHU Hua-jin WU Chun-xuan YANG Kang LIU Ting-wu LI Chen CAO Chuan-liang |
| author_facet | SHU Hua-jin WU Chun-xuan YANG Kang LIU Ting-wu LI Chen CAO Chuan-liang |
| author_sort | SHU Hua-jin |
| collection | DOAJ |
| description | Silica nanofibers were prepared by electrospinning technique, and then a sodium alginate coated three-dimensional silica hemostatic sponge (ALG/SiO<sub>2</sub>/Ca<sup>2+</sup> sponge) was obtained by freeze-drying method and Ca<sup>2+</sup> crosslinking. The structure, composition, cytotoxicity, biocompatibility and hemostatic function were characterized by scanning electron microscopy, cell experiments and <i>in vivo</i> hemostasis experiment. The results show that the ALG/SiO<sub>2</sub>/Ca<sup>2+</sup> hemostatic sponge has a highly porous structure and fast swelling performance. Immersed in water for 10s, the volume expands to 219% compared with the original. The results of cell experiments show that the new hemostatic sponge has good cytocompatibility; the results of <i>in vivo</i> hemostasis show that hemostasis is achieved within 10s using the ALG/SiO<sub>2</sub>/Ca<sup>2+</sup> hemostatic sponge, and the amount of bleeding is significantly reduced compared with medical gauze. Therefore, this new type of hemostatic sponge has excellent properties such as rapid water swelling and hemostasis in the deep wound and providing a moist environment for wound. |
| first_indexed | 2024-04-11T01:50:47Z |
| format | Article |
| id | doaj.art-4531933f8984462da43512789f415d95 |
| institution | Directory Open Access Journal |
| issn | 1001-4381 1001-4381 |
| language | zho |
| last_indexed | 2024-04-11T01:50:47Z |
| publishDate | 2019-12-01 |
| publisher | Journal of Materials Engineering |
| record_format | Article |
| series | Cailiao gongcheng |
| spelling | doaj.art-4531933f8984462da43512789f415d952023-01-03T06:26:51ZzhoJournal of Materials EngineeringCailiao gongcheng1001-43811001-43812019-12-01471212412910.11868/j.issn.1001-4381.2019.000699201912000699Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic functionSHU Hua-jin0WU Chun-xuan1YANG Kang2LIU Ting-wu3LI Chen4CAO Chuan-liang5Hospital of Nanchang University, Nanchang 330031, ChinaThe Second Clinical Medical School, Nanchang University, Nanchang 330006, ChinaCollege of Pharmacy, Nanchang University, Nanchang 330031, ChinaCollege of Pharmacy, Nanchang University, Nanchang 330031, ChinaThe Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaSchool of Mechanical and Electronic Engineering, Nanchang University, Nanchang 330031, ChinaSilica nanofibers were prepared by electrospinning technique, and then a sodium alginate coated three-dimensional silica hemostatic sponge (ALG/SiO<sub>2</sub>/Ca<sup>2+</sup> sponge) was obtained by freeze-drying method and Ca<sup>2+</sup> crosslinking. The structure, composition, cytotoxicity, biocompatibility and hemostatic function were characterized by scanning electron microscopy, cell experiments and <i>in vivo</i> hemostasis experiment. The results show that the ALG/SiO<sub>2</sub>/Ca<sup>2+</sup> hemostatic sponge has a highly porous structure and fast swelling performance. Immersed in water for 10s, the volume expands to 219% compared with the original. The results of cell experiments show that the new hemostatic sponge has good cytocompatibility; the results of <i>in vivo</i> hemostasis show that hemostasis is achieved within 10s using the ALG/SiO<sub>2</sub>/Ca<sup>2+</sup> hemostatic sponge, and the amount of bleeding is significantly reduced compared with medical gauze. Therefore, this new type of hemostatic sponge has excellent properties such as rapid water swelling and hemostasis in the deep wound and providing a moist environment for wound.http://jme.biam.ac.cn/CN/Y2019/V47/I12/124silica fiberelectrospinninghemostatic spongebiocompatibilityrapid swelling |
| spellingShingle | SHU Hua-jin WU Chun-xuan YANG Kang LIU Ting-wu LI Chen CAO Chuan-liang Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function Cailiao gongcheng silica fiber electrospinning hemostatic sponge biocompatibility rapid swelling |
| title | Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function |
| title_full | Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function |
| title_fullStr | Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function |
| title_full_unstemmed | Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function |
| title_short | Preparation of rapid expansion alginate/silica fiber composite scaffold and application of rapid hemostatic function |
| title_sort | preparation of rapid expansion alginate silica fiber composite scaffold and application of rapid hemostatic function |
| topic | silica fiber electrospinning hemostatic sponge biocompatibility rapid swelling |
| url | http://jme.biam.ac.cn/CN/Y2019/V47/I12/124 |
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