Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence
Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have cont...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/9/838 |
| _version_ | 1797581020372926464 |
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| author | Zhirong He Kun Xu Yongming Li Han Gao Tingting Miao Rui Zhao Yanyan Huang |
| author_facet | Zhirong He Kun Xu Yongming Li Han Gao Tingting Miao Rui Zhao Yanyan Huang |
| author_sort | Zhirong He |
| collection | DOAJ |
| description | Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have contributed greatly to this field. This review focuses on the recent progress in fluorescent sensors for molecularly targeted imaging and real-time tracking of cellular senescence. The molecular design, sensing mechanisms, and biological activities of the sensors are discussed. The sensors are categorized by the types of markers and targeting ligands. Accordingly, their molecular recognition and fluorescent performance towards senescence biomarkers are summarized. Finally, the perspective and challenges in this field are discussed, which are expected to assist future design of next-generation sensors for monitoring cellular senescence. |
| first_indexed | 2024-03-10T22:59:11Z |
| format | Article |
| id | doaj.art-45330cdbfa6f4fa78442773a29869627 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T22:59:11Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-45330cdbfa6f4fa78442773a298696272023-11-19T09:47:02ZengMDPI AGBiosensors2079-63742023-08-0113983810.3390/bios13090838Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular SenescenceZhirong He0Kun Xu1Yongming Li2Han Gao3Tingting Miao4Rui Zhao5Yanyan Huang6College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, ChinaBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaCollege of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, ChinaBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaSpecific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have contributed greatly to this field. This review focuses on the recent progress in fluorescent sensors for molecularly targeted imaging and real-time tracking of cellular senescence. The molecular design, sensing mechanisms, and biological activities of the sensors are discussed. The sensors are categorized by the types of markers and targeting ligands. Accordingly, their molecular recognition and fluorescent performance towards senescence biomarkers are summarized. Finally, the perspective and challenges in this field are discussed, which are expected to assist future design of next-generation sensors for monitoring cellular senescence.https://www.mdpi.com/2079-6374/13/9/838cellular senescencefluorescent sensorsmolecular recognitiontargeted imaging |
| spellingShingle | Zhirong He Kun Xu Yongming Li Han Gao Tingting Miao Rui Zhao Yanyan Huang Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence Biosensors cellular senescence fluorescent sensors molecular recognition targeted imaging |
| title | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
| title_full | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
| title_fullStr | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
| title_full_unstemmed | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
| title_short | Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence |
| title_sort | molecularly targeted fluorescent sensors for visualizing and tracking cellular senescence |
| topic | cellular senescence fluorescent sensors molecular recognition targeted imaging |
| url | https://www.mdpi.com/2079-6374/13/9/838 |
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