Membrane-Active Peptides and Their Potential Biomedical Application
Membrane-active peptides (MAPs) possess unique properties that make them valuable tools for studying membrane structure and function and promising candidates for therapeutic applications. This review paper provides an overview of the fundamental aspects of MAPs, focusing on their membrane interactio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/8/2091 |
| _version_ | 1797583475118702592 |
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| author | Andreea Gostaviceanu Simona Gavrilaş Lucian Copolovici Dana Maria Copolovici |
| author_facet | Andreea Gostaviceanu Simona Gavrilaş Lucian Copolovici Dana Maria Copolovici |
| author_sort | Andreea Gostaviceanu |
| collection | DOAJ |
| description | Membrane-active peptides (MAPs) possess unique properties that make them valuable tools for studying membrane structure and function and promising candidates for therapeutic applications. This review paper provides an overview of the fundamental aspects of MAPs, focusing on their membrane interaction mechanisms and potential applications. MAPs exhibit various structural features, including amphipathic structures and specific amino acid residues, enabling selective interaction with multiple membranes. Their mechanisms of action involve disrupting lipid bilayers through different pathways, depending on peptide properties and membrane composition. The therapeutic potential of MAPs is significant. They have demonstrated antimicrobial activity against bacteria and fungi, making them promising alternatives to conventional antibiotics. MAPs can selectively target cancer cells and induce apoptosis, opening new avenues in cancer therapeutics. Additionally, MAPs serve as drug delivery vectors, facilitating the transport of therapeutic cargoes across cell membranes. They represent a fascinating class of biomolecules with significant potential in basic research and clinical applications. Understanding their mechanisms of action and designing peptides with enhanced selectivity and efficacy will further expand their utility in diverse fields. Exploring MAPs holds promise for developing novel therapeutic strategies against infections, cancer, and drug delivery challenges. |
| first_indexed | 2024-03-10T23:39:25Z |
| format | Article |
| id | doaj.art-45334812ccdb4c4599b8647619d0ac18 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:39:25Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-45334812ccdb4c4599b8647619d0ac182023-11-19T02:36:40ZengMDPI AGPharmaceutics1999-49232023-08-01158209110.3390/pharmaceutics15082091Membrane-Active Peptides and Their Potential Biomedical ApplicationAndreea Gostaviceanu0Simona Gavrilaş1Lucian Copolovici2Dana Maria Copolovici3Faculty of Food Engineering, Tourism and Environmental Protection, and Institute for Research, Development and Innovation in Technical and Natural Sciences, Aurel Vlaicu University, Elena Drăgoi St., No. 2, 310330 Arad, RomaniaFaculty of Food Engineering, Tourism and Environmental Protection, and Institute for Research, Development and Innovation in Technical and Natural Sciences, Aurel Vlaicu University, Elena Drăgoi St., No. 2, 310330 Arad, RomaniaFaculty of Food Engineering, Tourism and Environmental Protection, and Institute for Research, Development and Innovation in Technical and Natural Sciences, Aurel Vlaicu University, Elena Drăgoi St., No. 2, 310330 Arad, RomaniaFaculty of Food Engineering, Tourism and Environmental Protection, and Institute for Research, Development and Innovation in Technical and Natural Sciences, Aurel Vlaicu University, Elena Drăgoi St., No. 2, 310330 Arad, RomaniaMembrane-active peptides (MAPs) possess unique properties that make them valuable tools for studying membrane structure and function and promising candidates for therapeutic applications. This review paper provides an overview of the fundamental aspects of MAPs, focusing on their membrane interaction mechanisms and potential applications. MAPs exhibit various structural features, including amphipathic structures and specific amino acid residues, enabling selective interaction with multiple membranes. Their mechanisms of action involve disrupting lipid bilayers through different pathways, depending on peptide properties and membrane composition. The therapeutic potential of MAPs is significant. They have demonstrated antimicrobial activity against bacteria and fungi, making them promising alternatives to conventional antibiotics. MAPs can selectively target cancer cells and induce apoptosis, opening new avenues in cancer therapeutics. Additionally, MAPs serve as drug delivery vectors, facilitating the transport of therapeutic cargoes across cell membranes. They represent a fascinating class of biomolecules with significant potential in basic research and clinical applications. Understanding their mechanisms of action and designing peptides with enhanced selectivity and efficacy will further expand their utility in diverse fields. Exploring MAPs holds promise for developing novel therapeutic strategies against infections, cancer, and drug delivery challenges.https://www.mdpi.com/1999-4923/15/8/2091membrane-active peptidesantimicrobial peptidescell-penetrating peptidestumor-homing peptidespeptide synthesiscancer |
| spellingShingle | Andreea Gostaviceanu Simona Gavrilaş Lucian Copolovici Dana Maria Copolovici Membrane-Active Peptides and Their Potential Biomedical Application Pharmaceutics membrane-active peptides antimicrobial peptides cell-penetrating peptides tumor-homing peptides peptide synthesis cancer |
| title | Membrane-Active Peptides and Their Potential Biomedical Application |
| title_full | Membrane-Active Peptides and Their Potential Biomedical Application |
| title_fullStr | Membrane-Active Peptides and Their Potential Biomedical Application |
| title_full_unstemmed | Membrane-Active Peptides and Their Potential Biomedical Application |
| title_short | Membrane-Active Peptides and Their Potential Biomedical Application |
| title_sort | membrane active peptides and their potential biomedical application |
| topic | membrane-active peptides antimicrobial peptides cell-penetrating peptides tumor-homing peptides peptide synthesis cancer |
| url | https://www.mdpi.com/1999-4923/15/8/2091 |
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