Epidermal Hyaluronan in Barrier Alteration-Related Disease
In skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components. Herein, we review knowledge about structure, localization and role of epidermal hyaluronan (H...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/11/3096 |
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| author | Céline Evrard Catherine Lambert de Rouvroit Yves Poumay |
| author_facet | Céline Evrard Catherine Lambert de Rouvroit Yves Poumay |
| author_sort | Céline Evrard |
| collection | DOAJ |
| description | In skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components. Herein, we review knowledge about structure, localization and role of epidermal hyaluronan (HA), a key ECM molecule. HA is a non-sulfated glycosaminoglycan non-covalently bound to proteins or lipids. Components of the basal lamina maintain some segregation between the epidermis and the underlying dermis, and all epidermal HA is locally synthesized and degraded. Functions of HA in keratinocyte proliferation and differentiation are still controversial. However, through interactions with partners, such as the TSG-6 protein, HA is involved in the formation, organization and stabilization of the epidermal ECM. In addition, epidermal HA is involved in the formation of an efficient epidermal barrier made of cornified keratinocytes. In atopic dermatitis (AD) with profuse alterations of the epidermal barrier, HA is produced in larger amounts by keratinocytes than in normal skin. Epidermal HA inside AD lesional skin is located in enlarged intercellular spaces, likely as the result of disease-related modifications of HA metabolism. |
| first_indexed | 2024-03-10T05:36:11Z |
| format | Article |
| id | doaj.art-4533df450a2d48a1866f9177d0c9f06c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:36:11Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4533df450a2d48a1866f9177d0c9f06c2023-11-22T22:51:15ZengMDPI AGCells2073-44092021-11-011011309610.3390/cells10113096Epidermal Hyaluronan in Barrier Alteration-Related DiseaseCéline Evrard0Catherine Lambert de Rouvroit1Yves Poumay2Research Unit for Molecular Physiology (URPhyM), Department of Medicine, Namur Research Institute for Life Sciences (NARILIS), University of Namur, B-5000 Namur, BelgiumResearch Unit for Molecular Physiology (URPhyM), Department of Medicine, Namur Research Institute for Life Sciences (NARILIS), University of Namur, B-5000 Namur, BelgiumResearch Unit for Molecular Physiology (URPhyM), Department of Medicine, Namur Research Institute for Life Sciences (NARILIS), University of Namur, B-5000 Namur, BelgiumIn skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components. Herein, we review knowledge about structure, localization and role of epidermal hyaluronan (HA), a key ECM molecule. HA is a non-sulfated glycosaminoglycan non-covalently bound to proteins or lipids. Components of the basal lamina maintain some segregation between the epidermis and the underlying dermis, and all epidermal HA is locally synthesized and degraded. Functions of HA in keratinocyte proliferation and differentiation are still controversial. However, through interactions with partners, such as the TSG-6 protein, HA is involved in the formation, organization and stabilization of the epidermal ECM. In addition, epidermal HA is involved in the formation of an efficient epidermal barrier made of cornified keratinocytes. In atopic dermatitis (AD) with profuse alterations of the epidermal barrier, HA is produced in larger amounts by keratinocytes than in normal skin. Epidermal HA inside AD lesional skin is located in enlarged intercellular spaces, likely as the result of disease-related modifications of HA metabolism.https://www.mdpi.com/2073-4409/10/11/3096hyaluronanepidermal extracellular matrixatopic dermatitis |
| spellingShingle | Céline Evrard Catherine Lambert de Rouvroit Yves Poumay Epidermal Hyaluronan in Barrier Alteration-Related Disease Cells hyaluronan epidermal extracellular matrix atopic dermatitis |
| title | Epidermal Hyaluronan in Barrier Alteration-Related Disease |
| title_full | Epidermal Hyaluronan in Barrier Alteration-Related Disease |
| title_fullStr | Epidermal Hyaluronan in Barrier Alteration-Related Disease |
| title_full_unstemmed | Epidermal Hyaluronan in Barrier Alteration-Related Disease |
| title_short | Epidermal Hyaluronan in Barrier Alteration-Related Disease |
| title_sort | epidermal hyaluronan in barrier alteration related disease |
| topic | hyaluronan epidermal extracellular matrix atopic dermatitis |
| url | https://www.mdpi.com/2073-4409/10/11/3096 |
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