Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis
CD4+ and CD8+ T lymphocyte counts, naive and memory/effector CD4+ T subpopulations, and the expression of CD38 on CD8+ T lymphocytes were evaluated in four groups: AIDS patients with tuberculosis (HIV/TB, n=14), HIV-1 infected patients (HIV, n=10), HIV-1 negative patients with tuberculosis (TB, n=20...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200010&lng=en&tlng=en |
| _version_ | 1818962854366150656 |
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| author | Denise do Socorro S. Rodrigues Rosangela M. de C. Cunha Esper Georges Kallas Reinaldo Salomao |
| author_facet | Denise do Socorro S. Rodrigues Rosangela M. de C. Cunha Esper Georges Kallas Reinaldo Salomao |
| author_sort | Denise do Socorro S. Rodrigues |
| collection | DOAJ |
| description | CD4+ and CD8+ T lymphocyte counts, naive and memory/effector CD4+ T subpopulations, and the expression of CD38 on CD8+ T lymphocytes were evaluated in four groups: AIDS patients with tuberculosis (HIV/TB, n=14), HIV-1 infected patients (HIV, n=10), HIV-1 negative patients with tuberculosis (TB, n=20) and healthy controls (CTL, n=17). TB and HIV had fewer CD4+ T cells than CTL, with the lowest values observed in TB/HIV (p<0.001). No difference between groups was observed in the percentage of naive and memory/effector subpopulations in CD4+ T lymphocytes. TB (355 cells/mL) and HIV (517 cells/mL) had diverging effects on CD8+ T cell counts, with a marked depletion observed in HIV/TB (196 cells/mL). TB and HIV up-regulated CD38 expression on CD8+ T cells, a finding also present in TB/HIV. While the decrease of CD4+ T cell counts in HIV/TB may be attributed to HIV and tuberculosis, the decrease of CD8+ T cell counts is likely to be due to tuberculosis. |
| first_indexed | 2024-12-20T12:35:56Z |
| format | Article |
| id | doaj.art-4534108882074e16aa4e438fc6f07cfb |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-20T12:35:56Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-4534108882074e16aa4e438fc6f07cfb2022-12-21T19:40:37ZengElsevierBrazilian Journal of Infectious Diseases1678-43917216116510.1590/S1413-86702003000200010S1413-86702003000200010Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosisDenise do Socorro S. Rodrigues0Rosangela M. de C. Cunha1Esper Georges Kallas2Reinaldo Salomao3Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloCD4+ and CD8+ T lymphocyte counts, naive and memory/effector CD4+ T subpopulations, and the expression of CD38 on CD8+ T lymphocytes were evaluated in four groups: AIDS patients with tuberculosis (HIV/TB, n=14), HIV-1 infected patients (HIV, n=10), HIV-1 negative patients with tuberculosis (TB, n=20) and healthy controls (CTL, n=17). TB and HIV had fewer CD4+ T cells than CTL, with the lowest values observed in TB/HIV (p<0.001). No difference between groups was observed in the percentage of naive and memory/effector subpopulations in CD4+ T lymphocytes. TB (355 cells/mL) and HIV (517 cells/mL) had diverging effects on CD8+ T cell counts, with a marked depletion observed in HIV/TB (196 cells/mL). TB and HIV up-regulated CD38 expression on CD8+ T cells, a finding also present in TB/HIV. While the decrease of CD4+ T cell counts in HIV/TB may be attributed to HIV and tuberculosis, the decrease of CD8+ T cell counts is likely to be due to tuberculosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200010&lng=en&tlng=enTuberculosisAIDSCD38CD4+CD8+ T lymphocytes |
| spellingShingle | Denise do Socorro S. Rodrigues Rosangela M. de C. Cunha Esper Georges Kallas Reinaldo Salomao Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis Brazilian Journal of Infectious Diseases Tuberculosis AIDS CD38 CD4+ CD8+ T lymphocytes |
| title | Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis |
| title_full | Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis |
| title_fullStr | Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis |
| title_full_unstemmed | Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis |
| title_short | Distribution of naive and memory/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis |
| title_sort | distribution of naive and memory effector cd4 t lymphocytes and expression of cd38 on cd8 t lymphocytes in aids patients with tuberculosis |
| topic | Tuberculosis AIDS CD38 CD4+ CD8+ T lymphocytes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200010&lng=en&tlng=en |
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