lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons

lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons

Fused-in sarcoma (FUS) gene mutations have been implicated in amyotrophic lateral sclerosis (ALS). This study aimed to investigate the impact of FUS mutations (R521H and P525L) on the transcriptome of induced pluripotent stem cells (iPSCs) and iPSC-derived motor neurons (iMNs). Using RNA sequencing...

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Bibliographic Details
Main Authors: Vincent E. Provasek, Manohar Kodavati, Wenting Guo, Haibo Wang, Istvan Boldogh, Ludo Van Den Bosch, Gavin Britz, Muralidhar L. Hegde
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
fused-in sarcoma (FUS)
neurodegenerative disorders
induced pluripotent stem cells (iPSCs)
long non-coding RNAs (lncRNAs)
RNA sequencing
Online Access:https://www.mdpi.com/2073-4409/12/20/2461

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