Selenium binding protein 1 inhibits tumor angiogenesis in colorectal cancers by blocking the Delta-like ligand 4/Notch1 signaling pathway

Selenium binding protein 1 inhibits tumor angiogenesis in colorectal cancers by blocking the Delta-like ligand 4/Notch1 signaling pathway

Background: Selenium binding protein 1 (SELENBP1) is frequently downregulated in malignancies such as colorectal cancer (CRC), however, whether it is involved in tumor angiogenesis is still unknown. Methods: We analyzed the expression and localization of SELENBP1 in vessels from CRC and neighboring...

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Bibliographic Details
Main Authors: Xiaotian Zhang, Runqi Hong, Lanxin Bei, Ju Yang, Xiaomei Zhao, Zhiqing Hu, Liang Chen, He Meng, Qian Zhang, Gengming Niu, Ying Yue, Chongwei Ke
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Translational Oncology
Subjects:
Selenium binding protein
Colorectal cancer
Angiogenesis
Delta-like ligand 4
Notch signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523322000274

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