The immunomodulation role of Th17 and Treg in renal transplantation
Kidney transplantation (KT) is an ultimate treatment of end-stage chronic kidney disease, which can meet a lot of complications induced by immune system. With under-controlled immunosuppression, the patient will obtain a good prognosis. Otherwise, allograft disfunction will cause severe organ failur...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113560/full |
| _version_ | 1797938035106512896 |
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| author | Dan-Lei Huang Yi-Ran He Yu-Jing Liu Hong-Yu He Zhun-Yong Gu Yi-Mei Liu Wen-Jun Liu Zhe Luo Min-Jie Ju |
| author_facet | Dan-Lei Huang Yi-Ran He Yu-Jing Liu Hong-Yu He Zhun-Yong Gu Yi-Mei Liu Wen-Jun Liu Zhe Luo Min-Jie Ju |
| author_sort | Dan-Lei Huang |
| collection | DOAJ |
| description | Kidney transplantation (KT) is an ultimate treatment of end-stage chronic kidney disease, which can meet a lot of complications induced by immune system. With under-controlled immunosuppression, the patient will obtain a good prognosis. Otherwise, allograft disfunction will cause severe organ failure and even immune collapse. Acute or chronic allograft dysfunction after KT is related to Th17, Treg, and Th17/Treg to a certain extent. Elevated Th17 levels may lead to acute rejection or chronic allograft dysfunction. Treg mainly plays a protective role on allografts by regulating immune response. The imbalance of the two may further aggravate the balance of immune response and damage the allograft. Controlling Th17 level, improving Treg function and level, and adjusting Th17/Treg ratio may have positive effects on longer allograft survival and better prognosis of receptors. |
| first_indexed | 2024-04-10T18:53:30Z |
| format | Article |
| id | doaj.art-453539e6baae468eb229de2cef1c9663 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T18:53:30Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-453539e6baae468eb229de2cef1c96632023-02-01T04:46:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11135601113560The immunomodulation role of Th17 and Treg in renal transplantationDan-Lei Huang0Yi-Ran He1Yu-Jing Liu2Hong-Yu He3Zhun-Yong Gu4Yi-Mei Liu5Wen-Jun Liu6Zhe Luo7Min-Jie Ju8Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Nursing, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Urinary Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaKidney transplantation (KT) is an ultimate treatment of end-stage chronic kidney disease, which can meet a lot of complications induced by immune system. With under-controlled immunosuppression, the patient will obtain a good prognosis. Otherwise, allograft disfunction will cause severe organ failure and even immune collapse. Acute or chronic allograft dysfunction after KT is related to Th17, Treg, and Th17/Treg to a certain extent. Elevated Th17 levels may lead to acute rejection or chronic allograft dysfunction. Treg mainly plays a protective role on allografts by regulating immune response. The imbalance of the two may further aggravate the balance of immune response and damage the allograft. Controlling Th17 level, improving Treg function and level, and adjusting Th17/Treg ratio may have positive effects on longer allograft survival and better prognosis of receptors.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113560/fullrenal transplantationT cellTh17TregTh17/Treg |
| spellingShingle | Dan-Lei Huang Yi-Ran He Yu-Jing Liu Hong-Yu He Zhun-Yong Gu Yi-Mei Liu Wen-Jun Liu Zhe Luo Min-Jie Ju The immunomodulation role of Th17 and Treg in renal transplantation Frontiers in Immunology renal transplantation T cell Th17 Treg Th17/Treg |
| title | The immunomodulation role of Th17 and Treg in renal transplantation |
| title_full | The immunomodulation role of Th17 and Treg in renal transplantation |
| title_fullStr | The immunomodulation role of Th17 and Treg in renal transplantation |
| title_full_unstemmed | The immunomodulation role of Th17 and Treg in renal transplantation |
| title_short | The immunomodulation role of Th17 and Treg in renal transplantation |
| title_sort | immunomodulation role of th17 and treg in renal transplantation |
| topic | renal transplantation T cell Th17 Treg Th17/Treg |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1113560/full |
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