Autophagy and salivary gland cancer: A putative target for salivary gland tumors
Salivary gland carcinomas are a group of heterogeneous tumors of different histological subtypes, presenting relatively low incidence but the entire variable of types. Although novel treatment options for salivary gland carcinomas patients’ outcomes have improved, the treatment of this type of cance...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IOS Press
2020-12-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428320980568 |
| _version_ | 1819319982339653632 |
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| author | Evangelos Koustas Panagiotis Sarantis Margarita Theodorakidou Michalis V Karamouzis Stamatios Theocharis |
| author_facet | Evangelos Koustas Panagiotis Sarantis Margarita Theodorakidou Michalis V Karamouzis Stamatios Theocharis |
| author_sort | Evangelos Koustas |
| collection | DOAJ |
| description | Salivary gland carcinomas are a group of heterogeneous tumors of different histological subtypes, presenting relatively low incidence but the entire variable of types. Although novel treatment options for salivary gland carcinomas patients’ outcomes have improved, the treatment of this type of cancer is still not standardized. In addition, a significant number of patients, with a lack of optimal treatment strategies, have reduced survival. In the last two decades, a plethora of evidence pointed to the importance of autophagy, an essential catabolic process of cytoplasmatic component digestion, in cancer. In vitro and in vivo studies highlight the importance of autophagy in salivary gland carcinomas development as a tumor suppressor or promoter mechanism. Despite the potential of autophagy in salivary gland carcinomas development, no therapies are currently available that specifically focus on autophagy modulation in salivary gland carcinomas. In this review, we summarize current knowledge and clinical trials in regard to the interplay between autophagy and the development of salivary gland carcinomas. Autophagy manipulation may be a putative therapeutic strategy for salivary gland carcinomas patients. |
| first_indexed | 2024-12-24T11:12:20Z |
| format | Article |
| id | doaj.art-4536093489744d4dae2ac237a9216a06 |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-24T11:12:20Z |
| publishDate | 2020-12-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-4536093489744d4dae2ac237a9216a062022-12-21T16:58:29ZengIOS PressTumor Biology1423-03802020-12-014210.1177/1010428320980568Autophagy and salivary gland cancer: A putative target for salivary gland tumorsEvangelos Koustas0Panagiotis Sarantis1Margarita Theodorakidou2Michalis V Karamouzis3Stamatios Theocharis4Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, GreeceFirst Department of Internal Medicine, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, Athens, GreeceLaboratory of Experimental Surgery and Surgical Research “N.S.Christeas,” Medical School, National and Kapodistrian University of Athens, Athens, GreeceSalivary gland carcinomas are a group of heterogeneous tumors of different histological subtypes, presenting relatively low incidence but the entire variable of types. Although novel treatment options for salivary gland carcinomas patients’ outcomes have improved, the treatment of this type of cancer is still not standardized. In addition, a significant number of patients, with a lack of optimal treatment strategies, have reduced survival. In the last two decades, a plethora of evidence pointed to the importance of autophagy, an essential catabolic process of cytoplasmatic component digestion, in cancer. In vitro and in vivo studies highlight the importance of autophagy in salivary gland carcinomas development as a tumor suppressor or promoter mechanism. Despite the potential of autophagy in salivary gland carcinomas development, no therapies are currently available that specifically focus on autophagy modulation in salivary gland carcinomas. In this review, we summarize current knowledge and clinical trials in regard to the interplay between autophagy and the development of salivary gland carcinomas. Autophagy manipulation may be a putative therapeutic strategy for salivary gland carcinomas patients.https://doi.org/10.1177/1010428320980568 |
| spellingShingle | Evangelos Koustas Panagiotis Sarantis Margarita Theodorakidou Michalis V Karamouzis Stamatios Theocharis Autophagy and salivary gland cancer: A putative target for salivary gland tumors Tumor Biology |
| title | Autophagy and salivary gland cancer: A putative target for salivary gland tumors |
| title_full | Autophagy and salivary gland cancer: A putative target for salivary gland tumors |
| title_fullStr | Autophagy and salivary gland cancer: A putative target for salivary gland tumors |
| title_full_unstemmed | Autophagy and salivary gland cancer: A putative target for salivary gland tumors |
| title_short | Autophagy and salivary gland cancer: A putative target for salivary gland tumors |
| title_sort | autophagy and salivary gland cancer a putative target for salivary gland tumors |
| url | https://doi.org/10.1177/1010428320980568 |
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