Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses

Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses

Objectives: Uncovering the genetic basis of COVID-19 may shed insight into its pathogenesis and help to improve treatment measures. We aimed to investigate the host genetic variants associated with COVID-19.Methods: The summary result of a COVID-19 GWAS (9,373 hospitalized COVID-19 cases and 1,197,2...

Full description

Bibliographic Details
Main Authors:	Ancha Baranova, Hongbao Cao, Fuquan Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Medicine
Subjects:	GWAS COVID-19 TWAS eQTL mQTL
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2021.738687/full

Similar Items

Integrate GWAS, eQTL, and mQTL Data to Identify Alzheimer’s Disease-Related Genes
by: Tianyi Zhao, et al.
Published: (2019-10-01)

Finding the genes for fragile bones
by: Erika Kague
Published: (2022-12-01)

Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations
by: Basel Maher Al-Barghouthi, et al.
Published: (2022-11-01)

The eQTL colocalization and transcriptome-wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle
by: Wentao Cai, et al.
Published: (2023-05-01)

Disentangling the genetics of sarcopenia: prioritization of NUDT3 and KLF5 as genes for lean mass & HLA-DQB1-AS1 for hand grip strength with the associated enhancing SNPs & a scoring system
by: Abhishek Narain Singh, et al.
Published: (2020-02-01)

Identification of highly reliable risk genes for Alzheimer’s disease through joint-tissue integrative analysis
by: Yong Heng Wang, et al.
Published: (2023-06-01)

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters
by: Siriluck Ponsuksili, et al.
Published: (2019-04-01)

Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information
by: Huseyin Gedik, et al.
Published: (2023-06-01)

An optimal variant to gene distance window derived from an empirical definition of cis and trans protein QTLs
by: Eric B. Fauman, et al.
Published: (2022-05-01)

From GWAS to Gene: Transcriptome-Wide Association Studies and Other Methods to Functionally Understand GWAS Discoveries
by: Binglan Li, et al.
Published: (2021-09-01)

Learning from Fifteen Years of Genome-Wide Association Studies in Age-Related Macular Degeneration
by: Tobias Strunz, et al.
Published: (2020-10-01)

The impact of cell type and context-dependent regulatory variants on human immune traits
by: Zepeng Mu, et al.
Published: (2021-04-01)

A microRNA Transcriptome-wide Association Study of Prostate Cancer Risk
by: Nicholas B. Larson, et al.
Published: (2022-03-01)

Integration of eQTL Analysis and GWAS Highlights Regulation Networks in Cotton under Stress Condition
by: Xiao Han, et al.
Published: (2022-07-01)

Corrigendum: Research progress and trends in metabolomics of fruit trees
by: Jing Li, et al.
Published: (2023-04-01)

Research Progress and Trends in Metabolomics of Fruit Trees
by: Jing Li, et al.
Published: (2022-04-01)

Comprehensive and integrative analyses identify TYW5 as a schizophrenia risk gene
by: Chengcheng Zhang, et al.
Published: (2022-05-01)

Mean-Variance QTL Mapping Identifies Novel QTL for Circadian Activity and Exploratory Behavior in Mice
by: Robert W. Corty, et al.
Published: (2018-12-01)

eQTpLot: a user-friendly R package for the visualization of colocalization between eQTL and GWAS signals
by: Theodore G. Drivas, et al.
Published: (2021-07-01)

Integrative analysis of summary data from GWAS and eQTL studies implicates genes differentially expressed in Alzheimer’s disease
by: Brian Lee, et al.
Published: (2022-06-01)

Multi-omics analysis dissects the genetic architecture of seed coat content in Brassica napus
by: Yuting Zhang, et al.
Published: (2022-03-01)

Mapping QTL for white striping in relation to breast muscle yield and meat quality traits in broiler chickens
by: Eva Pampouille, et al.
Published: (2018-03-01)

TIGAR-V2: Efficient TWAS tool with nonparametric Bayesian eQTL weights of 49 tissue types from GTEx V8
by: Randy L. Parrish, et al.
Published: (2022-01-01)

LORSEN: Fast and Efficient eQTL Mapping With Low Rank Penalized Regression
by: Cheng Gao, et al.
Published: (2021-11-01)

IsomiR-eQTL: A Cancer-Specific Expression Quantitative Trait Loci Database of miRNAs and Their Isoforms
by: Afshin Moradi, et al.
Published: (2022-10-01)

mGWAS-Explorer: Linking SNPs, Genes, Metabolites, and Diseases for Functional Insights
by: Le Chang, et al.
Published: (2022-06-01)

Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains
by: Pradeep Varathan, et al.
Published: (2022-04-01)

Trait correlated expression combined with eQTL and ASE analyses identified novel candidate genes affecting intramuscular fat
by: Yan Liu, et al.
Published: (2021-11-01)

Identification of Alzheimer's Disease-Related Genes Based on Data Integration Method
by: Yang Hu, et al.
Published: (2019-01-01)

A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension
by: Xiao Xiao, et al.
Published: (2022-11-01)

Genetic Mechanism Revealed of Age-Related Macular Degeneration Based on Fusion of Statistics and Machine Learning Method
by: Yongyi Du, et al.
Published: (2021-08-01)

An Integrative Analysis of Transcriptome and GWAS Data to Identify Potential Candidate Genes Influencing Meat Quality Traits in Pigs
by: Xianxian Liu, et al.
Published: (2021-10-01)

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction
by: Joel Lavinsky, et al.
Published: (2016-10-01)

GWAS Meta-Analysis Reveals Shared Genes and Biological Pathways between Major Depressive Disorder and Insomnia
by: Yi-Sian Lin, et al.
Published: (2021-09-01)

The interaction of Epstein-Barr virus encoded transcription factor EBNA2 with multiple sclerosis risk loci is dependent on the risk genotype
by: Jeremy Thomas Keane, et al.
Published: (2021-09-01)

To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes
by: Amelia D. Wallace, et al.
Published: (2018-08-01)

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
by: Benjamin H. Mullin, et al.
Published: (2020-03-01)

Applying multi-omics data to study the genetic background of bovine respiratory disease infection in feedlot crossbred cattle
by: Jiyuan Li, et al.
Published: (2022-12-01)

Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data
by: Fei Shen, et al.
Published: (2021-02-01)

Leveraging the transcriptome to further our understanding of GWAS findings: eQTLs associated with genes related to LDL and LDL subclasses, in a cohort of African Americans
by: Malak Abbas, et al.
Published: (2024-02-01)