Natural-Based Biomaterials for Peripheral Nerve Injury Repair
Peripheral nerve injury treatment is a relevant problem because of nerve lesion high incidence and because of unsatisfactory regeneration after severe injuries, thus resulting in a reduced patient’s life quality. To repair severe nerve injuries characterized by substance loss and to improve the rege...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.554257/full |
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| author | Benedetta E. Fornasari Benedetta E. Fornasari Giacomo Carta Giacomo Carta Giovanna Gambarotta Giovanna Gambarotta Stefania Raimondo Stefania Raimondo |
| author_facet | Benedetta E. Fornasari Benedetta E. Fornasari Giacomo Carta Giacomo Carta Giovanna Gambarotta Giovanna Gambarotta Stefania Raimondo Stefania Raimondo |
| author_sort | Benedetta E. Fornasari |
| collection | DOAJ |
| description | Peripheral nerve injury treatment is a relevant problem because of nerve lesion high incidence and because of unsatisfactory regeneration after severe injuries, thus resulting in a reduced patient’s life quality. To repair severe nerve injuries characterized by substance loss and to improve the regeneration outcome at both motor and sensory level, different strategies have been investigated. Although autograft remains the gold standard technique, a growing number of research articles concerning nerve conduit use has been reported in the last years. Nerve conduits aim to overcome autograft disadvantages, but they must satisfy some requirements to be suitable for nerve repair. A universal ideal conduit does not exist, since conduit properties have to be evaluated case by case; nevertheless, because of their high biocompatibility and biodegradability, natural-based biomaterials have great potentiality to be used to produce nerve guides. Although they share many characteristics with synthetic biomaterials, natural-based biomaterials should also be preferable because of their extraction sources; indeed, these biomaterials are obtained from different renewable sources or food waste, thus reducing environmental impact and enhancing sustainability in comparison to synthetic ones. This review reports the strengths and weaknesses of natural-based biomaterials used for manufacturing peripheral nerve conduits, analyzing the interactions between natural-based biomaterials and biological environment. Particular attention was paid to the description of the preclinical outcome of nerve regeneration in injury repaired with the different natural-based conduits. |
| first_indexed | 2024-12-11T06:28:42Z |
| format | Article |
| id | doaj.art-453bce8cb56a43c6895ae34bd9553178 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-11T06:28:42Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-453bce8cb56a43c6895ae34bd95531782022-12-22T01:17:35ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-10-01810.3389/fbioe.2020.554257554257Natural-Based Biomaterials for Peripheral Nerve Injury RepairBenedetta E. Fornasari0Benedetta E. Fornasari1Giacomo Carta2Giacomo Carta3Giovanna Gambarotta4Giovanna Gambarotta5Stefania Raimondo6Stefania Raimondo7Department of Clinical and Biological Sciences, University of Turin, Turin, ItalyNeuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyNeuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyNeuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyNeuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin, ItalyPeripheral nerve injury treatment is a relevant problem because of nerve lesion high incidence and because of unsatisfactory regeneration after severe injuries, thus resulting in a reduced patient’s life quality. To repair severe nerve injuries characterized by substance loss and to improve the regeneration outcome at both motor and sensory level, different strategies have been investigated. Although autograft remains the gold standard technique, a growing number of research articles concerning nerve conduit use has been reported in the last years. Nerve conduits aim to overcome autograft disadvantages, but they must satisfy some requirements to be suitable for nerve repair. A universal ideal conduit does not exist, since conduit properties have to be evaluated case by case; nevertheless, because of their high biocompatibility and biodegradability, natural-based biomaterials have great potentiality to be used to produce nerve guides. Although they share many characteristics with synthetic biomaterials, natural-based biomaterials should also be preferable because of their extraction sources; indeed, these biomaterials are obtained from different renewable sources or food waste, thus reducing environmental impact and enhancing sustainability in comparison to synthetic ones. This review reports the strengths and weaknesses of natural-based biomaterials used for manufacturing peripheral nerve conduits, analyzing the interactions between natural-based biomaterials and biological environment. Particular attention was paid to the description of the preclinical outcome of nerve regeneration in injury repaired with the different natural-based conduits.https://www.frontiersin.org/article/10.3389/fbioe.2020.554257/fullbiopolymertissue engineeringperipheral nerve repairnerve guidance conduitnatural biomaterial |
| spellingShingle | Benedetta E. Fornasari Benedetta E. Fornasari Giacomo Carta Giacomo Carta Giovanna Gambarotta Giovanna Gambarotta Stefania Raimondo Stefania Raimondo Natural-Based Biomaterials for Peripheral Nerve Injury Repair Frontiers in Bioengineering and Biotechnology biopolymer tissue engineering peripheral nerve repair nerve guidance conduit natural biomaterial |
| title | Natural-Based Biomaterials for Peripheral Nerve Injury Repair |
| title_full | Natural-Based Biomaterials for Peripheral Nerve Injury Repair |
| title_fullStr | Natural-Based Biomaterials for Peripheral Nerve Injury Repair |
| title_full_unstemmed | Natural-Based Biomaterials for Peripheral Nerve Injury Repair |
| title_short | Natural-Based Biomaterials for Peripheral Nerve Injury Repair |
| title_sort | natural based biomaterials for peripheral nerve injury repair |
| topic | biopolymer tissue engineering peripheral nerve repair nerve guidance conduit natural biomaterial |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.554257/full |
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