Research Progress of DNA Methylation in Endometrial Cancer
Endometrial cancer (EC)) is one of the most common malignant tumors of the female genital system, with an increasing incidence and mortality, worldwide. Although the therapeutic strategy of EC is still complicated and challenging, further understanding of carcinogenesis from a gene perspective would...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/7/938 |
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| author | Ting Xu Hongmei Ding Jie Chen Jiahui Lei Meng Zhao Bingyu Ji Youguo Chen Songbing Qin Qinqin Gao |
| author_facet | Ting Xu Hongmei Ding Jie Chen Jiahui Lei Meng Zhao Bingyu Ji Youguo Chen Songbing Qin Qinqin Gao |
| author_sort | Ting Xu |
| collection | DOAJ |
| description | Endometrial cancer (EC)) is one of the most common malignant tumors of the female genital system, with an increasing incidence and mortality, worldwide. Although the therapeutic strategy of EC is still complicated and challenging, further understanding of carcinogenesis from a gene perspective would allow an effort to improve therapeutic precision in this complex malignancy. DNA methylation is the most widely studied epigenetic alteration in human tumors. Aberrant DNA methylation events, resulting in altered gene expression, are features of many tumor types. In this review, we provide an update on evidence about the roles of aberrant DNA methylation within some classical tumor suppressor genes and oncogenes in endometrial carcinogenesis, and report on recent advances in the understanding of the contribution of aberrant DNA methylation to EC, as well as opportunities and challenges of DNA methylation in EC management and prevention. |
| first_indexed | 2024-03-09T03:39:15Z |
| format | Article |
| id | doaj.art-453f909881f14400820991b5575da7d3 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T03:39:15Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-453f909881f14400820991b5575da7d32023-12-03T14:43:29ZengMDPI AGBiomolecules2218-273X2022-07-0112793810.3390/biom12070938Research Progress of DNA Methylation in Endometrial CancerTing Xu0Hongmei Ding1Jie Chen2Jiahui Lei3Meng Zhao4Bingyu Ji5Youguo Chen6Songbing Qin7Qinqin Gao8Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaEndometrial cancer (EC)) is one of the most common malignant tumors of the female genital system, with an increasing incidence and mortality, worldwide. Although the therapeutic strategy of EC is still complicated and challenging, further understanding of carcinogenesis from a gene perspective would allow an effort to improve therapeutic precision in this complex malignancy. DNA methylation is the most widely studied epigenetic alteration in human tumors. Aberrant DNA methylation events, resulting in altered gene expression, are features of many tumor types. In this review, we provide an update on evidence about the roles of aberrant DNA methylation within some classical tumor suppressor genes and oncogenes in endometrial carcinogenesis, and report on recent advances in the understanding of the contribution of aberrant DNA methylation to EC, as well as opportunities and challenges of DNA methylation in EC management and prevention.https://www.mdpi.com/2218-273X/12/7/938DNA methylationtumor suppressor genesoncogenesendometrial cancer |
| spellingShingle | Ting Xu Hongmei Ding Jie Chen Jiahui Lei Meng Zhao Bingyu Ji Youguo Chen Songbing Qin Qinqin Gao Research Progress of DNA Methylation in Endometrial Cancer Biomolecules DNA methylation tumor suppressor genes oncogenes endometrial cancer |
| title | Research Progress of DNA Methylation in Endometrial Cancer |
| title_full | Research Progress of DNA Methylation in Endometrial Cancer |
| title_fullStr | Research Progress of DNA Methylation in Endometrial Cancer |
| title_full_unstemmed | Research Progress of DNA Methylation in Endometrial Cancer |
| title_short | Research Progress of DNA Methylation in Endometrial Cancer |
| title_sort | research progress of dna methylation in endometrial cancer |
| topic | DNA methylation tumor suppressor genes oncogenes endometrial cancer |
| url | https://www.mdpi.com/2218-273X/12/7/938 |
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