Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers
Objective: This study aimed to evaluate the activity of delta-aminolevulinate dehydratase (δ-ALA-D) and oxidative stress biomarkers in pregnant women with gestational diabetes mellitus (GDM), in order to demonstrate the involvement of oxidative stress in this condition, which presents pathophysiolog...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Redox Report |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/13510002.2017.1402981 |
| _version_ | 1818293504085852160 |
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| author | Fabiane Rodrigues Leidiane de Lucca Walter S. Neme Thissiane de Lima Gonçalves |
| author_facet | Fabiane Rodrigues Leidiane de Lucca Walter S. Neme Thissiane de Lima Gonçalves |
| author_sort | Fabiane Rodrigues |
| collection | DOAJ |
| description | Objective: This study aimed to evaluate the activity of delta-aminolevulinate dehydratase (δ-ALA-D) and oxidative stress biomarkers in pregnant women with gestational diabetes mellitus (GDM), in order to demonstrate the involvement of oxidative stress in this condition, which presents pathophysiology still undetermined. Methods: δ-ALA-D activity, lipid peroxidation estimated as the levels of thiobarbituric acid reactive substances (TBARS), protein (P-SH) and non-protein thiol (NP-SH) content, catalase (CAT) activity and concentration of vitamin C (VIT C) in samples of pregnant women with GDM (n = 48) and in healthy pregnant women (n = 30), who constituted the control group. Results: The δ-ALA-D activity was significantly lower in pregnant women with GDM compared to controls, as well as levels of thiols, VIT C and CAT activity. Lipid peroxidation was higher in GDM group. Discussion: The results suggest that the main factor for the increase in oxidative stress and reduced δ-ALA-D activity in diabetic pregnant women is gestational hyperglycemic environment, which changed the redox balance and interfered on mechanism of the δ-ALA-D activity in relation to normoglycemic pregnant women. |
| first_indexed | 2024-12-13T03:16:54Z |
| format | Article |
| id | doaj.art-453fa1a4d84d4ee4afb0a4a79cbf6cb6 |
| institution | Directory Open Access Journal |
| issn | 1351-0002 1743-2928 |
| language | English |
| last_indexed | 2024-12-13T03:16:54Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Redox Report |
| spelling | doaj.art-453fa1a4d84d4ee4afb0a4a79cbf6cb62022-12-22T00:01:27ZengTaylor & Francis GroupRedox Report1351-00021743-29282018-01-01231636710.1080/13510002.2017.14029811402981Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkersFabiane Rodrigues0Leidiane de Lucca1Walter S. Neme2Thissiane de Lima Gonçalves3Federal University of Santa Maria (UFSM)Federal University of Santa Maria (UFSM)Federal University of Santa Maria (UFSM)Federal University of Santa Maria (UFSM)Objective: This study aimed to evaluate the activity of delta-aminolevulinate dehydratase (δ-ALA-D) and oxidative stress biomarkers in pregnant women with gestational diabetes mellitus (GDM), in order to demonstrate the involvement of oxidative stress in this condition, which presents pathophysiology still undetermined. Methods: δ-ALA-D activity, lipid peroxidation estimated as the levels of thiobarbituric acid reactive substances (TBARS), protein (P-SH) and non-protein thiol (NP-SH) content, catalase (CAT) activity and concentration of vitamin C (VIT C) in samples of pregnant women with GDM (n = 48) and in healthy pregnant women (n = 30), who constituted the control group. Results: The δ-ALA-D activity was significantly lower in pregnant women with GDM compared to controls, as well as levels of thiols, VIT C and CAT activity. Lipid peroxidation was higher in GDM group. Discussion: The results suggest that the main factor for the increase in oxidative stress and reduced δ-ALA-D activity in diabetic pregnant women is gestational hyperglycemic environment, which changed the redox balance and interfered on mechanism of the δ-ALA-D activity in relation to normoglycemic pregnant women.http://dx.doi.org/10.1080/13510002.2017.1402981Delta-aminolevulinate dehydrataseoxidative stressgestational diabetes mellituspregnant women |
| spellingShingle | Fabiane Rodrigues Leidiane de Lucca Walter S. Neme Thissiane de Lima Gonçalves Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers Redox Report Delta-aminolevulinate dehydratase oxidative stress gestational diabetes mellitus pregnant women |
| title | Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers |
| title_full | Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers |
| title_fullStr | Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers |
| title_full_unstemmed | Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers |
| title_short | Influence of gestational diabetes on the activity of δ-aminolevulinate dehydratase and oxidative stress biomarkers |
| title_sort | influence of gestational diabetes on the activity of δ aminolevulinate dehydratase and oxidative stress biomarkers |
| topic | Delta-aminolevulinate dehydratase oxidative stress gestational diabetes mellitus pregnant women |
| url | http://dx.doi.org/10.1080/13510002.2017.1402981 |
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