Role of Probiotics in Modulating Human Gut Microbiota Populations and Activities in Patients with Colorectal Cancer—A Systematic Review of Clinical Trials
Background: Growing attention has been given to the role of nutrition and alterations of microbial diversity of the gut microbiota in colorectal cancer (CRC) pathogenesis. It has been suggested that probiotics and synbiotics modulate enteric microbiota and therefore may be used as an intervention to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/4/1160 |
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| author | Adrianna Wierzbicka Dorota Mańkowska-Wierzbicka Marcin Mardas Marta Stelmach-Mardas |
| author_facet | Adrianna Wierzbicka Dorota Mańkowska-Wierzbicka Marcin Mardas Marta Stelmach-Mardas |
| author_sort | Adrianna Wierzbicka |
| collection | DOAJ |
| description | Background: Growing attention has been given to the role of nutrition and alterations of microbial diversity of the gut microbiota in colorectal cancer (CRC) pathogenesis. It has been suggested that probiotics and synbiotics modulate enteric microbiota and therefore may be used as an intervention to reduce the risk of CRC. The aim of this study was to evaluate the influence of probiotics/synbiotics administration on gut microbiota in patients with CRC. Methods: PubMed, Scopus, and Web of Science were searched between December 2020 and January 2021. Randomized controlled trials (RCTs) recruiting adults with CRC, who have taken probiotics/synbiotics for at least 6 days were included. Changes in gut microbiota and selected biochemical and inflammatory parameters (i.e., hsCRP, IL-2, hemoglobin) were retrieved. Results: The search resulted in 198 original research articles and a final 6 were selected as being eligible, including 457 subjects. The median age of patients was 65.4 years old and they were characterized by the median BMI value: 23.8 kg/m<sup>2</sup>. The literature search revealed that probiotic/synbiotic administration improved enteric microbiota by increasing the abundance of beneficial bacteria such as <i>Lactobacillus, Eubacterium, Peptostreptococcus, Bacillus</i> and <i>Bifidobacterium</i>, and decreased the abundance of potentially harmful bacteria such as <i>Fusobacterium, Porhyromonas, Pseudomonas</i> and <i>Enterococcus</i>. Additionally, probiotic/synbiotic intervention improved release of antimicrobials, intestinal permeability, tight junction function in CRC patients. Conclusions: The use of probiotics/synbiotics positively modulates enteric microbiota, improves postoperative outcomes, gut barrier function and reduces inflammatory parameters in patients suffering from CRC. |
| first_indexed | 2024-03-10T12:42:27Z |
| format | Article |
| id | doaj.art-453fa4e83a864c4fb1b11de8e4d36728 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T12:42:27Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-453fa4e83a864c4fb1b11de8e4d367282023-11-21T13:44:25ZengMDPI AGNutrients2072-66432021-04-01134116010.3390/nu13041160Role of Probiotics in Modulating Human Gut Microbiota Populations and Activities in Patients with Colorectal Cancer—A Systematic Review of Clinical TrialsAdrianna Wierzbicka0Dorota Mańkowska-Wierzbicka1Marcin Mardas2Marta Stelmach-Mardas3Department of Obesity Treatment, Metabolic Disorders and Clinical Dietetics Poznań University of Medical Sciences, Szamarzewskiego 84, 60-569 Poznań, PolandDepartment of Gastroenterology, Metabolic Diseases, Internal Medicine and Dietetics, Poznan University of Medical Sciences, 84, 60-569 Poznań, PolandDepartment of Oncology, Poznan University of Medical Sciences, 84, 60-569 Poznań, PolandDepartment of Obesity Treatment, Metabolic Disorders and Clinical Dietetics Poznań University of Medical Sciences, Szamarzewskiego 84, 60-569 Poznań, PolandBackground: Growing attention has been given to the role of nutrition and alterations of microbial diversity of the gut microbiota in colorectal cancer (CRC) pathogenesis. It has been suggested that probiotics and synbiotics modulate enteric microbiota and therefore may be used as an intervention to reduce the risk of CRC. The aim of this study was to evaluate the influence of probiotics/synbiotics administration on gut microbiota in patients with CRC. Methods: PubMed, Scopus, and Web of Science were searched between December 2020 and January 2021. Randomized controlled trials (RCTs) recruiting adults with CRC, who have taken probiotics/synbiotics for at least 6 days were included. Changes in gut microbiota and selected biochemical and inflammatory parameters (i.e., hsCRP, IL-2, hemoglobin) were retrieved. Results: The search resulted in 198 original research articles and a final 6 were selected as being eligible, including 457 subjects. The median age of patients was 65.4 years old and they were characterized by the median BMI value: 23.8 kg/m<sup>2</sup>. The literature search revealed that probiotic/synbiotic administration improved enteric microbiota by increasing the abundance of beneficial bacteria such as <i>Lactobacillus, Eubacterium, Peptostreptococcus, Bacillus</i> and <i>Bifidobacterium</i>, and decreased the abundance of potentially harmful bacteria such as <i>Fusobacterium, Porhyromonas, Pseudomonas</i> and <i>Enterococcus</i>. Additionally, probiotic/synbiotic intervention improved release of antimicrobials, intestinal permeability, tight junction function in CRC patients. Conclusions: The use of probiotics/synbiotics positively modulates enteric microbiota, improves postoperative outcomes, gut barrier function and reduces inflammatory parameters in patients suffering from CRC.https://www.mdpi.com/2072-6643/13/4/1160probioticsgut microbiotahuman microbiomecolorectal cancerchronic diseasesmicronutrients |
| spellingShingle | Adrianna Wierzbicka Dorota Mańkowska-Wierzbicka Marcin Mardas Marta Stelmach-Mardas Role of Probiotics in Modulating Human Gut Microbiota Populations and Activities in Patients with Colorectal Cancer—A Systematic Review of Clinical Trials Nutrients probiotics gut microbiota human microbiome colorectal cancer chronic diseases micronutrients |
| title | Role of Probiotics in Modulating Human Gut Microbiota Populations and Activities in Patients with Colorectal Cancer—A Systematic Review of Clinical Trials |
| title_full | Role of Probiotics in Modulating Human Gut Microbiota Populations and Activities in Patients with Colorectal Cancer—A Systematic Review of Clinical Trials |
| title_fullStr | Role of Probiotics in Modulating Human Gut Microbiota Populations and Activities in Patients with Colorectal Cancer—A Systematic Review of Clinical Trials |
| title_full_unstemmed | Role of Probiotics in Modulating Human Gut Microbiota Populations and Activities in Patients with Colorectal Cancer—A Systematic Review of Clinical Trials |
| title_short | Role of Probiotics in Modulating Human Gut Microbiota Populations and Activities in Patients with Colorectal Cancer—A Systematic Review of Clinical Trials |
| title_sort | role of probiotics in modulating human gut microbiota populations and activities in patients with colorectal cancer a systematic review of clinical trials |
| topic | probiotics gut microbiota human microbiome colorectal cancer chronic diseases micronutrients |
| url | https://www.mdpi.com/2072-6643/13/4/1160 |
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