Assessment of Thymic Output Dynamics After in utero Infection of Mice With Coxsackievirus B4

Assessment of Thymic Output Dynamics After in utero Infection of Mice With Coxsackievirus B4

The thymus is the main organ of the lymphatic system, in which T cells undergo a rigorous selection to ensure that their receptors (TCRs) will be functional and will not react against the self. Genes encoding for TCR chains are fragmented and must be rearranged by a process of somatic recombination...

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Bibliographic Details
Main Authors: Aymen Halouani, Habib Jmii, Gwennaëlle Bodart, Hélène Michaux, Chantal Renard, Henri Martens, Mahjoub Aouni, Didier Hober, Vincent Geenen, Hela Jaïdane
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
thymus
T cell
thymic export
T cell receptor (TCR) rearrangement excision circles
autoimmune diseases
Ptk7 gene
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00481/full

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