Molecular Basis for Drug Resistance in HIV-1 Protease

Molecular Basis for Drug Resistance in HIV-1 Protease

HIV-1 protease is one of the major antiviral targets in the treatment of patients infected with HIV-1. The nine FDA approved HIV-1 protease inhibitors were developed with extensive use of structure-based drug design, thus the atomic details of how the inhibitors bind are well characterized. From thi...

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Bibliographic Details
Main Authors: Celia A. Schiffer, Kelly Thayer, Ellen A. Nalivaika, Ayşegül Özen, Moses M. Prabu-Jeyabalan, Madhavi N.L. Nalam, Nancy M. King, Rajintha M. Bandaranayake, Jennifer F. Murzycki, Seema Mittal, Madhavi Kolli, Yufeng Cai, Akbar Ali
Format: Article
Language:English
Published: MDPI AG 2010-11-01
Series:Viruses
Subjects:
drug resistance
HIV-1 protease
protease inhibitors
substrate envelope
structure based drug design
Online Access:http://www.mdpi.com/1999-4915/2/11/2509/

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