A rare case of solitary fibrous tumor of the temporal region: 7-year-follow-up clinical-radiographic evaluation and literature review
Solitary fibrous tumor is a rare spindle-cell neoplasm of mesenchymal origin. In head and neck region, the tumors present slow-growing masses, often with local compressive symptoms. Although it is generally benign, malignant variants have been identified. The radiological diagnosis of solitary fibro...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Oral and Maxillofacial Surgery Cases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214541921000341 |
| _version_ | 1828426177989050368 |
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| author | Ugo Consolo Francesco Diamante Attilio Carlo Salgarelli Pierantonio Bellini |
| author_facet | Ugo Consolo Francesco Diamante Attilio Carlo Salgarelli Pierantonio Bellini |
| author_sort | Ugo Consolo |
| collection | DOAJ |
| description | Solitary fibrous tumor is a rare spindle-cell neoplasm of mesenchymal origin. In head and neck region, the tumors present slow-growing masses, often with local compressive symptoms. Although it is generally benign, malignant variants have been identified. The radiological diagnosis of solitary fibrous tumor is usually based on computer tomography and/or magnetic resonance imaging. Microscopically, a solitary fibrous tumor is characteristically a circumscribed neoplasm composed of variably cellular and patternless distributions of bland spindle and ovoid cells within variably collagenous stroma that frequently shows areas of dense hyalinisation, as well as interspersed large branching or “staghorn”- shaped thin-walled vessels. Immunohistochemical staining is very effective to distinguish solitary fibrous tumors from other fibroblastic tumors. Recently, NAB2–STAT6 gene fusion derived from inv12 (q13q13) has been reported as the genetic hallmark of solitary fibrous tumor. Complete local surgical excision appears to be the treatment of choice for solitary fibrous tumor of the head and neck region. Recurrence was reported in 5% of cases. The median recurrence-free interval was 36.5 months. We report the case of a solitary fibrous tumor of the temporal region, surgically excised and with no clinical and/or radiological signs of recurrence after 7 years of follow-up. |
| first_indexed | 2024-12-10T16:41:54Z |
| format | Article |
| id | doaj.art-4543e6a647df410eb35e504e2d3481e1 |
| institution | Directory Open Access Journal |
| issn | 2214-5419 |
| language | English |
| last_indexed | 2024-12-10T16:41:54Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral and Maxillofacial Surgery Cases |
| spelling | doaj.art-4543e6a647df410eb35e504e2d3481e12022-12-22T01:41:11ZengElsevierOral and Maxillofacial Surgery Cases2214-54192022-03-0181100240A rare case of solitary fibrous tumor of the temporal region: 7-year-follow-up clinical-radiographic evaluation and literature reviewUgo Consolo0Francesco Diamante1Attilio Carlo Salgarelli2Pierantonio Bellini3Head of Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, Director of Postgraduate School of Oral Surgery, University of Modena and Reggio Emilia, Modena, ItalyPostgraduate School of Oral Surgery, University of Modena and Reggio Emilia, Modena, Italy; Corresponding author. Policlinico di Modena-Azienda Ospedaliero-Universitaria di Modena, Largo del Pozzo, 71, 41125, Modena, Mo, Italy.Head of Maxillofacial Unit, Hospital “Carlo Poma”, Mantova, ItalyProfessor of Postgraduate School of Oral Surgery, University of Modena and Reggio Emilia, Modena, ItalySolitary fibrous tumor is a rare spindle-cell neoplasm of mesenchymal origin. In head and neck region, the tumors present slow-growing masses, often with local compressive symptoms. Although it is generally benign, malignant variants have been identified. The radiological diagnosis of solitary fibrous tumor is usually based on computer tomography and/or magnetic resonance imaging. Microscopically, a solitary fibrous tumor is characteristically a circumscribed neoplasm composed of variably cellular and patternless distributions of bland spindle and ovoid cells within variably collagenous stroma that frequently shows areas of dense hyalinisation, as well as interspersed large branching or “staghorn”- shaped thin-walled vessels. Immunohistochemical staining is very effective to distinguish solitary fibrous tumors from other fibroblastic tumors. Recently, NAB2–STAT6 gene fusion derived from inv12 (q13q13) has been reported as the genetic hallmark of solitary fibrous tumor. Complete local surgical excision appears to be the treatment of choice for solitary fibrous tumor of the head and neck region. Recurrence was reported in 5% of cases. The median recurrence-free interval was 36.5 months. We report the case of a solitary fibrous tumor of the temporal region, surgically excised and with no clinical and/or radiological signs of recurrence after 7 years of follow-up.http://www.sciencedirect.com/science/article/pii/S2214541921000341Solitary fibrous tumorHemangiopericytomaTemporal muscleMaxillofacial surgeryMaxillofacial pathology |
| spellingShingle | Ugo Consolo Francesco Diamante Attilio Carlo Salgarelli Pierantonio Bellini A rare case of solitary fibrous tumor of the temporal region: 7-year-follow-up clinical-radiographic evaluation and literature review Oral and Maxillofacial Surgery Cases Solitary fibrous tumor Hemangiopericytoma Temporal muscle Maxillofacial surgery Maxillofacial pathology |
| title | A rare case of solitary fibrous tumor of the temporal region: 7-year-follow-up clinical-radiographic evaluation and literature review |
| title_full | A rare case of solitary fibrous tumor of the temporal region: 7-year-follow-up clinical-radiographic evaluation and literature review |
| title_fullStr | A rare case of solitary fibrous tumor of the temporal region: 7-year-follow-up clinical-radiographic evaluation and literature review |
| title_full_unstemmed | A rare case of solitary fibrous tumor of the temporal region: 7-year-follow-up clinical-radiographic evaluation and literature review |
| title_short | A rare case of solitary fibrous tumor of the temporal region: 7-year-follow-up clinical-radiographic evaluation and literature review |
| title_sort | rare case of solitary fibrous tumor of the temporal region 7 year follow up clinical radiographic evaluation and literature review |
| topic | Solitary fibrous tumor Hemangiopericytoma Temporal muscle Maxillofacial surgery Maxillofacial pathology |
| url | http://www.sciencedirect.com/science/article/pii/S2214541921000341 |
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