Commenting on the effects of surface treated- and non-surface treated TiO<sub>2</sub> in the Caco-2 cell model
<p>Abstract</p> <p>In a recent work published in <it>Particle and Fibre Toxicology</it> by Fisichella and coworkers investigating surface-modified TiO<sub>2</sub> nanoparticle exposure in a model human intestinal epithelium (Caco-2), albeit degraded to mimic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-11-01
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| Series: | Particle and Fibre Toxicology |
| Subjects: | |
| Online Access: | http://www.particleandfibretoxicology.com/content/9/1/42 |
| _version_ | 1828230800220356608 |
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| author | Faust James J Zhang Wen Koeneman Brian A Chen Yongsheng Capco David G |
| author_facet | Faust James J Zhang Wen Koeneman Brian A Chen Yongsheng Capco David G |
| author_sort | Faust James J |
| collection | DOAJ |
| description | <p>Abstract</p> <p>In a recent work published in <it>Particle and Fibre Toxicology</it> by Fisichella and coworkers investigating surface-modified TiO<sub>2</sub> nanoparticle exposure in a model human intestinal epithelium (Caco-2), albeit degraded to mimic conditions in the gut and exposure to natural sunlight, purportedly resulted in no toxic effects. The authors (Fisichella et al.) claim to have confirmed the results of a 2010 report by Koeneman et al. However, the study by Koeneman and colleagues revealed significant effects of unmodified TiO<sub>2</sub> nanoparticles. These contradicting data warrant further investigation into the possible effects of aluminum hydroxide, as these nanoparticles appear to have resulted in an abnormal apical surface in Caco-2 cells.</p> |
| first_indexed | 2024-04-12T18:53:49Z |
| format | Article |
| id | doaj.art-45488ccf976b40e3b9b98d10d92c1383 |
| institution | Directory Open Access Journal |
| issn | 1743-8977 |
| language | English |
| last_indexed | 2024-04-12T18:53:49Z |
| publishDate | 2012-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Particle and Fibre Toxicology |
| spelling | doaj.art-45488ccf976b40e3b9b98d10d92c13832022-12-22T03:20:24ZengBMCParticle and Fibre Toxicology1743-89772012-11-01914210.1186/1743-8977-9-42Commenting on the effects of surface treated- and non-surface treated TiO<sub>2</sub> in the Caco-2 cell modelFaust James JZhang WenKoeneman Brian AChen YongshengCapco David G<p>Abstract</p> <p>In a recent work published in <it>Particle and Fibre Toxicology</it> by Fisichella and coworkers investigating surface-modified TiO<sub>2</sub> nanoparticle exposure in a model human intestinal epithelium (Caco-2), albeit degraded to mimic conditions in the gut and exposure to natural sunlight, purportedly resulted in no toxic effects. The authors (Fisichella et al.) claim to have confirmed the results of a 2010 report by Koeneman et al. However, the study by Koeneman and colleagues revealed significant effects of unmodified TiO<sub>2</sub> nanoparticles. These contradicting data warrant further investigation into the possible effects of aluminum hydroxide, as these nanoparticles appear to have resulted in an abnormal apical surface in Caco-2 cells.</p>http://www.particleandfibretoxicology.com/content/9/1/42NanoparticlesTitanium dioxideMicrovilliBrush-borderCaco-2Transmission electron microscopyScanning electron microscopy |
| spellingShingle | Faust James J Zhang Wen Koeneman Brian A Chen Yongsheng Capco David G Commenting on the effects of surface treated- and non-surface treated TiO<sub>2</sub> in the Caco-2 cell model Particle and Fibre Toxicology Nanoparticles Titanium dioxide Microvilli Brush-border Caco-2 Transmission electron microscopy Scanning electron microscopy |
| title | Commenting on the effects of surface treated- and non-surface treated TiO<sub>2</sub> in the Caco-2 cell model |
| title_full | Commenting on the effects of surface treated- and non-surface treated TiO<sub>2</sub> in the Caco-2 cell model |
| title_fullStr | Commenting on the effects of surface treated- and non-surface treated TiO<sub>2</sub> in the Caco-2 cell model |
| title_full_unstemmed | Commenting on the effects of surface treated- and non-surface treated TiO<sub>2</sub> in the Caco-2 cell model |
| title_short | Commenting on the effects of surface treated- and non-surface treated TiO<sub>2</sub> in the Caco-2 cell model |
| title_sort | commenting on the effects of surface treated and non surface treated tio sub 2 sub in the caco 2 cell model |
| topic | Nanoparticles Titanium dioxide Microvilli Brush-border Caco-2 Transmission electron microscopy Scanning electron microscopy |
| url | http://www.particleandfibretoxicology.com/content/9/1/42 |
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