Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer
Introduction: Lysyl oxidase-like 4 is an amine oxidase from the lysyl oxidase family that was previously shown to be overexpressed in head and neck cancer and upregulated in response to hypoxia. The possible role of lysyl oxidase-like 4 as a tumor marker in advanced stage larynx cancer was investiga...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869421000549 |
| _version_ | 1797989887648989184 |
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| author | Ozan Muzaffer Altuntaş Nilda Süslü Yeşim Gaye Güler Tezel Hayriye Tatlı Doğan Taner Yılmaz |
| author_facet | Ozan Muzaffer Altuntaş Nilda Süslü Yeşim Gaye Güler Tezel Hayriye Tatlı Doğan Taner Yılmaz |
| author_sort | Ozan Muzaffer Altuntaş |
| collection | DOAJ |
| description | Introduction: Lysyl oxidase-like 4 is an amine oxidase from the lysyl oxidase family that was previously shown to be overexpressed in head and neck cancer and upregulated in response to hypoxia. The possible role of lysyl oxidase-like 4 as a tumor marker in advanced stage larynx cancer was investigated. Objective: To investigate the expression of lysyl Oxidase-Like 4 protein in advanced stage laryngeal cancer and elucidate its possible role as a tumor marker, predictor of treatment response and prognosticator. Methods: Diagnostic specimens of 72 patients treated for stage III–IV laryngeal squamous cell carcinoma were evaluated for lysyl oxidase-like 4 expression by immunohistochemistry. Results: Lysyl oxidase-like 4 expression was correlated with advanced tumor stage (p = 0.041) and better differentiation (p = 0.025) but was independent of tumor diameter (p = 0.456). Response to induction chemotherapy or the need for salvage laryngectomy were not affected by lysyl oxidase-like 4 expression (p = 0.999, p = 0.070 respectively). Increased lysyl oxidase-like 4 expression was associated with better 2 year overall survival in both univariate (p = 0.036) and multivariate analyses (p = 0.014). Conclusion: Lysyl oxidase-like 4 expression emerges with advancing stages, is lost with worsening differentiation, and may have tumor suppressive properties in larynx cancer. |
| first_indexed | 2024-04-11T08:27:50Z |
| format | Article |
| id | doaj.art-4548ac72848e4d118a43d15a0db4ecb9 |
| institution | Directory Open Access Journal |
| issn | 1808-8694 |
| language | English |
| last_indexed | 2024-04-11T08:27:50Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-4548ac72848e4d118a43d15a0db4ecb92022-12-22T04:34:41ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942022-11-01886968974Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancerOzan Muzaffer Altuntaş0Nilda Süslü1Yeşim Gaye Güler Tezel2Hayriye Tatlı Doğan3Taner Yılmaz4Koç University, Faculty of Medicine, Department of Otorhinolaryngology, Istanbul, Turkey; Corresponding author.Hacettepe University, Faculty of Medicine, Department of Otorhinolaryngology, Ankara, TurkeyHacettepe University, Faculty of Medicine, Department of Pathology, Ankara, TurkeyYıldırım Beyazıt University, Department of Pathology, Ankara, TurkeyHacettepe University, Faculty of Medicine, Department of Otorhinolaryngology, Ankara, TurkeyIntroduction: Lysyl oxidase-like 4 is an amine oxidase from the lysyl oxidase family that was previously shown to be overexpressed in head and neck cancer and upregulated in response to hypoxia. The possible role of lysyl oxidase-like 4 as a tumor marker in advanced stage larynx cancer was investigated. Objective: To investigate the expression of lysyl Oxidase-Like 4 protein in advanced stage laryngeal cancer and elucidate its possible role as a tumor marker, predictor of treatment response and prognosticator. Methods: Diagnostic specimens of 72 patients treated for stage III–IV laryngeal squamous cell carcinoma were evaluated for lysyl oxidase-like 4 expression by immunohistochemistry. Results: Lysyl oxidase-like 4 expression was correlated with advanced tumor stage (p = 0.041) and better differentiation (p = 0.025) but was independent of tumor diameter (p = 0.456). Response to induction chemotherapy or the need for salvage laryngectomy were not affected by lysyl oxidase-like 4 expression (p = 0.999, p = 0.070 respectively). Increased lysyl oxidase-like 4 expression was associated with better 2 year overall survival in both univariate (p = 0.036) and multivariate analyses (p = 0.014). Conclusion: Lysyl oxidase-like 4 expression emerges with advancing stages, is lost with worsening differentiation, and may have tumor suppressive properties in larynx cancer.http://www.sciencedirect.com/science/article/pii/S1808869421000549Larynx cancerLOXL4 proteinHypoxiaOrgan preservationPrognosis |
| spellingShingle | Ozan Muzaffer Altuntaş Nilda Süslü Yeşim Gaye Güler Tezel Hayriye Tatlı Doğan Taner Yılmaz Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer Brazilian Journal of Otorhinolaryngology Larynx cancer LOXL4 protein Hypoxia Organ preservation Prognosis |
| title | Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer |
| title_full | Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer |
| title_fullStr | Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer |
| title_full_unstemmed | Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer |
| title_short | Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer |
| title_sort | lysyl oxidase like 4 loxl4 as a tumor marker and prognosticator in advanced stage laryngeal cancer |
| topic | Larynx cancer LOXL4 protein Hypoxia Organ preservation Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1808869421000549 |
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