Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report
Abstract Anterior uveitis (AU) is the most common form of uveitis. The differential diagnosis of AU is broad, ranging from infectious etiologies to autoimmune causes. However, approximately half remain idiopathic. Infections are the vision-threatening causes of AU which should be ruled out by histor...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | Journal of Ophthalmic Inflammation and Infection |
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| Online Access: | http://link.springer.com/article/10.1186/s12348-020-00210-6 |
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| author | Ali Azimi Mohammad Shirvani Shahla Hosseini Vahid Bazojoo Nasrin Masihpoor Sahar Mohaghegh Seyed Mohammad Sadeghi |
| author_facet | Ali Azimi Mohammad Shirvani Shahla Hosseini Vahid Bazojoo Nasrin Masihpoor Sahar Mohaghegh Seyed Mohammad Sadeghi |
| author_sort | Ali Azimi |
| collection | DOAJ |
| description | Abstract Anterior uveitis (AU) is the most common form of uveitis. The differential diagnosis of AU is broad, ranging from infectious etiologies to autoimmune causes. However, approximately half remain idiopathic. Infections are the vision-threatening causes of AU which should be ruled out by history taking and detailed physical examination combined with guided work up. We report a rare case of bilateral granulomatous AU following hepatitis A virus (HAV) infection in an immunocompetent patient. A 35-year-old male presented to our center with a chief complaint of pain and redness in both eyes 3 days prior to the presentation. The patient’s medical and drug history was unremarkable. He had a history of river water consumption 20 days prior to presentation. The patient was diagnosed with acute bilateral granulomatous AU. All routine work up to investigate the etiology of the disease was unremarkable, except for the serology of acute HAV infection, which was positive. The patient was managed with the topical steroid and cycloplegic for 2 weeks with no recurrence at one-year follow up. Extra-hepatic complications of HAV were reported in previous studies including arthritis, urticaria, myocarditis, nephritis, and myositis. The mechanism of extra-hepatic complication of hepatitis A is unknown; however, immune-complex deposition is most likely the etiological cause. Our report represents a rare case of sudden onset with limited duration granulomatous AU as a presenting manifestation of HAV infection. Previous studies do not provide a direct evidence of granulomatous AU associated with the HAV infection. |
| first_indexed | 2024-04-12T03:55:59Z |
| format | Article |
| id | doaj.art-454d93af32a64ddcac91c2b042668b9a |
| institution | Directory Open Access Journal |
| issn | 1869-5760 |
| language | English |
| last_indexed | 2024-04-12T03:55:59Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Ophthalmic Inflammation and Infection |
| spelling | doaj.art-454d93af32a64ddcac91c2b042668b9a2022-12-22T03:48:50ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602020-08-011011410.1186/s12348-020-00210-6Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case reportAli Azimi0Mohammad Shirvani1Shahla Hosseini2Vahid Bazojoo3Nasrin Masihpoor4Sahar Mohaghegh5Seyed Mohammad Sadeghi6Poostchi Ophthalmology Research Center, Shiraz University of Medical SciencesPoostchi Ophthalmology Research Center, Shiraz University of Medical SciencesPoostchi Ophthalmology Research Center, Shiraz University of Medical SciencesPoostchi Ophthalmology Research Center, Shiraz University of Medical SciencesInfectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical SciencesOptometry Department, School of Rehabilitation, Shahid Beheshti University of Medical Sciences and Health ServicesPoostchi Ophthalmology Research Center, Shiraz University of Medical SciencesAbstract Anterior uveitis (AU) is the most common form of uveitis. The differential diagnosis of AU is broad, ranging from infectious etiologies to autoimmune causes. However, approximately half remain idiopathic. Infections are the vision-threatening causes of AU which should be ruled out by history taking and detailed physical examination combined with guided work up. We report a rare case of bilateral granulomatous AU following hepatitis A virus (HAV) infection in an immunocompetent patient. A 35-year-old male presented to our center with a chief complaint of pain and redness in both eyes 3 days prior to the presentation. The patient’s medical and drug history was unremarkable. He had a history of river water consumption 20 days prior to presentation. The patient was diagnosed with acute bilateral granulomatous AU. All routine work up to investigate the etiology of the disease was unremarkable, except for the serology of acute HAV infection, which was positive. The patient was managed with the topical steroid and cycloplegic for 2 weeks with no recurrence at one-year follow up. Extra-hepatic complications of HAV were reported in previous studies including arthritis, urticaria, myocarditis, nephritis, and myositis. The mechanism of extra-hepatic complication of hepatitis A is unknown; however, immune-complex deposition is most likely the etiological cause. Our report represents a rare case of sudden onset with limited duration granulomatous AU as a presenting manifestation of HAV infection. Previous studies do not provide a direct evidence of granulomatous AU associated with the HAV infection.http://link.springer.com/article/10.1186/s12348-020-00210-6UveitisHepatitis A virusInfectionVisual acuity |
| spellingShingle | Ali Azimi Mohammad Shirvani Shahla Hosseini Vahid Bazojoo Nasrin Masihpoor Sahar Mohaghegh Seyed Mohammad Sadeghi Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report Journal of Ophthalmic Inflammation and Infection Uveitis Hepatitis A virus Infection Visual acuity |
| title | Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report |
| title_full | Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report |
| title_fullStr | Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report |
| title_full_unstemmed | Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report |
| title_short | Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report |
| title_sort | acute bilateral granulomatous anterior uveitis as an extra hepatic manifestation of hepatitis a virus hav infection a case report |
| topic | Uveitis Hepatitis A virus Infection Visual acuity |
| url | http://link.springer.com/article/10.1186/s12348-020-00210-6 |
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