Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring
Aging affects most living organisms and includes the processes that reduce health and survival. The chronological and the biological age of individuals can differ remarkably, and there is a lack of reliable biomarkers to monitor the consequences of aging. In this review we give an overview of common...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.686320/full |
| _version_ | 1819320228743479296 |
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| author | Alexander Hartmann Christiane Hartmann Christiane Hartmann Riccardo Secci Andreas Hermann Andreas Hermann Georg Fuellen Michael Walter Michael Walter |
| author_facet | Alexander Hartmann Christiane Hartmann Christiane Hartmann Riccardo Secci Andreas Hermann Andreas Hermann Georg Fuellen Michael Walter Michael Walter |
| author_sort | Alexander Hartmann |
| collection | DOAJ |
| description | Aging affects most living organisms and includes the processes that reduce health and survival. The chronological and the biological age of individuals can differ remarkably, and there is a lack of reliable biomarkers to monitor the consequences of aging. In this review we give an overview of commonly mentioned and frequently used potential aging-related biomarkers. We were interested in biomarkers of aging in general and in biomarkers related to cellular senescence in particular. To answer the question whether a biological feature is relevant as a potential biomarker of aging or senescence in the scientific community we used the PICO strategy known from evidence-based medicine. We introduced two scoring systems, aimed at reflecting biomarker relevance and measurement effort, which can be used to support study designs in both clinical and research settings. |
| first_indexed | 2024-12-24T11:16:15Z |
| format | Article |
| id | doaj.art-454f6c4d242d4f6a908cac6d9992d6a0 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-24T11:16:15Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-454f6c4d242d4f6a908cac6d9992d6a02022-12-21T16:58:21ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-05-011210.3389/fgene.2021.686320686320Ranking Biomarkers of Aging by Citation Profiling and Effort ScoringAlexander Hartmann0Christiane Hartmann1Christiane Hartmann2Riccardo Secci3Andreas Hermann4Andreas Hermann5Georg Fuellen6Michael Walter7Michael Walter8Institute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, Rostock, GermanyTranslational Neurodegeneration Section “Albrecht-Kossel”, Department of Neurology, Rostock University Medical Center, Rostock, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Rostock, GermanyInstitute for Biostatistics and Informatics in Medicine and Aging Research, Rostock University Medical Center, Rostock, GermanyTranslational Neurodegeneration Section “Albrecht-Kossel”, Department of Neurology, Rostock University Medical Center, Rostock, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Rostock, GermanyInstitute for Biostatistics and Informatics in Medicine and Aging Research, Rostock University Medical Center, Rostock, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, Rostock, GermanyInstitute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité –Berlin Institute of Health, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, GermanyAging affects most living organisms and includes the processes that reduce health and survival. The chronological and the biological age of individuals can differ remarkably, and there is a lack of reliable biomarkers to monitor the consequences of aging. In this review we give an overview of commonly mentioned and frequently used potential aging-related biomarkers. We were interested in biomarkers of aging in general and in biomarkers related to cellular senescence in particular. To answer the question whether a biological feature is relevant as a potential biomarker of aging or senescence in the scientific community we used the PICO strategy known from evidence-based medicine. We introduced two scoring systems, aimed at reflecting biomarker relevance and measurement effort, which can be used to support study designs in both clinical and research settings.https://www.frontiersin.org/articles/10.3389/fgene.2021.686320/fullagingbiomarkerhealthsenescencesurvival |
| spellingShingle | Alexander Hartmann Christiane Hartmann Christiane Hartmann Riccardo Secci Andreas Hermann Andreas Hermann Georg Fuellen Michael Walter Michael Walter Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring Frontiers in Genetics aging biomarker health senescence survival |
| title | Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring |
| title_full | Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring |
| title_fullStr | Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring |
| title_full_unstemmed | Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring |
| title_short | Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring |
| title_sort | ranking biomarkers of aging by citation profiling and effort scoring |
| topic | aging biomarker health senescence survival |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.686320/full |
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