Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation

Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation

The current study aimed to develop a topical emulgel of dasatinib (DTB) for rheumatoid arthritis (RA) treatment to reduce systemic side effects. The quality by design (QbD) approach was employed to optimize DTB-loaded nano-emulgel using a central composite design (CCD). Emulgel was prepared using th...

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Bibliographic Details
Main Authors: Mahipal Reddy Donthi, Ranendra Narayan Saha, Gautam Singhvi, Sunil Kumar Dubey
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
dasatinib
local delivery
emulgel
skin permeation
anti-inflammatory activity
Freund’s complete adjuvant
Online Access:https://www.mdpi.com/1999-4923/15/3/736

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