Circ_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis

Circ_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis

Abstract The long-term high-fat diet (HFD) can cause myocardial lipotoxicity, which is characterized pathologically by myocardial hypertrophy, fibrosis, and remodeling and clinically by cardiac dysfunction and heart failure in patients with obesity and diabetes. Circular RNAs (circRNAs), a novel cla...

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Bibliographic Details
Main Authors: Xinzhu Ni, Lian Duan, Yandong Bao, Jinyang Li, Xiaowen Zhang, Dalin Jia, Nan Wu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cardiovascular Diabetology
Subjects:
High-fat diet
Myocardial lipotoxicity
Ferroptosis
Cyclophilin A
Online Access:https://doi.org/10.1186/s12933-024-02204-3

Internet

https://doi.org/10.1186/s12933-024-02204-3

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