Identification of Parkinson’s disease-associated chromatin regulators
Abstract Parkinson’s disease (PD) is a common neurological disorder that causes quiescent tremors, motor delays, depression, and sleep disturbances. Existing treatments can only improve symptoms, not stop progression or cure the disease, but effective treatments can significantly improve patients’ q...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-30236-4 |
| _version_ | 1797864747505287168 |
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| author | Hailong Xing Shanshan Wang Ke Li |
| author_facet | Hailong Xing Shanshan Wang Ke Li |
| author_sort | Hailong Xing |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is a common neurological disorder that causes quiescent tremors, motor delays, depression, and sleep disturbances. Existing treatments can only improve symptoms, not stop progression or cure the disease, but effective treatments can significantly improve patients’ quality of life. There is growing evidence that chromatin regulatory proteins (CRs) are involved in a variety of biological processes, including inflammation, apoptosis, autophagy, and proliferation. But the relationship of chromatin regulators in Parkinson’s disease has not been studied. Therefore, we aim to investigate the role of CRs in the pathogenesis of Parkinson’s disease. We collected 870 chromatin regulatory factors from previous studies and downloaded data on patients with PD from the GEO database. 64 differentially expressed genes were screened, the interaction network was constructed and the key genes with the top 20 scores were calculated. Then we discussed its correlation with the immune function of PD. Finally, we screened potential drugs and miRNAs. Five genes related to the immune function of PD, BANF1, PCGF5, WDR5, RYBP and BRD2, were obtained by using the absolute value of correlation greater than 0.4. And the disease prediction model showed good predictive efficiency. We also screened 10 related drugs and 12 related miRNAs, which provided a reference for the treatment of PD. BANF1, PCGF5, WDR5, RYBP and BRD2 are related to the immune process of Parkinson’s disease and can predict the occurrence of Parkinson’s disease, which is expected to become a new target for the diagnosis and treatment of Parkinson’s disease. |
| first_indexed | 2024-04-09T22:57:08Z |
| format | Article |
| id | doaj.art-4551e5120f9c4a04be88d14e6d48fb40 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:57:08Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4551e5120f9c4a04be88d14e6d48fb402023-03-22T11:10:39ZengNature PortfolioScientific Reports2045-23222023-02-0113111010.1038/s41598-023-30236-4Identification of Parkinson’s disease-associated chromatin regulatorsHailong Xing0Shanshan Wang1Ke Li2Department of Neurosurgery, Binzhou Medical University HospitalDepartment of Neurosurgery, Binzhou Central HospitalDepartment of Interventional Neurosurgery, Binzhou Medical University HospitalAbstract Parkinson’s disease (PD) is a common neurological disorder that causes quiescent tremors, motor delays, depression, and sleep disturbances. Existing treatments can only improve symptoms, not stop progression or cure the disease, but effective treatments can significantly improve patients’ quality of life. There is growing evidence that chromatin regulatory proteins (CRs) are involved in a variety of biological processes, including inflammation, apoptosis, autophagy, and proliferation. But the relationship of chromatin regulators in Parkinson’s disease has not been studied. Therefore, we aim to investigate the role of CRs in the pathogenesis of Parkinson’s disease. We collected 870 chromatin regulatory factors from previous studies and downloaded data on patients with PD from the GEO database. 64 differentially expressed genes were screened, the interaction network was constructed and the key genes with the top 20 scores were calculated. Then we discussed its correlation with the immune function of PD. Finally, we screened potential drugs and miRNAs. Five genes related to the immune function of PD, BANF1, PCGF5, WDR5, RYBP and BRD2, were obtained by using the absolute value of correlation greater than 0.4. And the disease prediction model showed good predictive efficiency. We also screened 10 related drugs and 12 related miRNAs, which provided a reference for the treatment of PD. BANF1, PCGF5, WDR5, RYBP and BRD2 are related to the immune process of Parkinson’s disease and can predict the occurrence of Parkinson’s disease, which is expected to become a new target for the diagnosis and treatment of Parkinson’s disease.https://doi.org/10.1038/s41598-023-30236-4 |
| spellingShingle | Hailong Xing Shanshan Wang Ke Li Identification of Parkinson’s disease-associated chromatin regulators Scientific Reports |
| title | Identification of Parkinson’s disease-associated chromatin regulators |
| title_full | Identification of Parkinson’s disease-associated chromatin regulators |
| title_fullStr | Identification of Parkinson’s disease-associated chromatin regulators |
| title_full_unstemmed | Identification of Parkinson’s disease-associated chromatin regulators |
| title_short | Identification of Parkinson’s disease-associated chromatin regulators |
| title_sort | identification of parkinson s disease associated chromatin regulators |
| url | https://doi.org/10.1038/s41598-023-30236-4 |
| work_keys_str_mv | AT hailongxing identificationofparkinsonsdiseaseassociatedchromatinregulators AT shanshanwang identificationofparkinsonsdiseaseassociatedchromatinregulators AT keli identificationofparkinsonsdiseaseassociatedchromatinregulators |