Hepatitis C in hemodialysis: the contribution of injection drug use
BACKGROUND: Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic r...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400020&lng=en&tlng=en |
| _version_ | 1818879791845081088 |
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| author | Bruno Galperim Angelo A Mattos Airton T Stein Nuttiane C Schneider André Buriol André Fonseca Vagner Lunge Nilo Ikuta |
| author_facet | Bruno Galperim Angelo A Mattos Airton T Stein Nuttiane C Schneider André Buriol André Fonseca Vagner Lunge Nilo Ikuta |
| author_sort | Bruno Galperim |
| collection | DOAJ |
| description | BACKGROUND: Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic renal disease on HD. METHODS: This was a multicenter cross-sectional study with 325 patients with chronic renal disease on HD in the period between August 1, 2005 to August 30, 2006, receiving care at four institutions in the city of Porto Alegre, Southern Brazil. Epidemiological data were collected by means of a structured questionnaire. The following laboratory tests were performed: alanine aminotransferase (ALT), anti-hepatitis C virus antibodies (anti-HCV), and qualitative polymerase chain reaction (PCR). RESULTS: Of 325 patients, 68 had positive HCV RNA results. The comparison between patients with positive and negative PCR results revealed significant differences in duration of HD (mean = 71 versus 52.4 months; p = 0.02); previous blood transfusion (92% versus 72%; p < 0.01); injection drug use (13% versus 0.7%; p < 0.01); anti-HCV positivity at start of HD therapy (60% versus 4%; p < 0.01); and mean ALT value (39 versus 26.5; p < 0.01). Logistic regression analysis showed a positive HCV RNA independently associated to being on HD for more than five years [OR: 2.1 (95% CI 1.2 -3.8)]; previous blood transfusion [OR: 3.7 (95% CI 1.4 - 9.5)]; and injection drug use [OR: 22.6 (95% CI 4.2 - 119.6)]. CONCLUSION: Injection drug use was an independent risk factor for HCV infection among chronic renal disease patients on HD. |
| first_indexed | 2024-12-19T14:35:42Z |
| format | Article |
| id | doaj.art-455298d7c4914ff8bb5611d85f7ea9fd |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-19T14:35:42Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-455298d7c4914ff8bb5611d85f7ea9fd2022-12-21T20:17:17ZengElsevierBrazilian Journal of Infectious Diseases1678-439114442242610.1590/S1413-86702010000400020S1413-86702010000400020Hepatitis C in hemodialysis: the contribution of injection drug useBruno Galperim0Angelo A Mattos1Airton T Stein2Nuttiane C Schneider3André Buriol4André Fonseca5Vagner Lunge6Nilo Ikuta7Hospital Mãe de DeusUniversidade Federal de Ciências da Saúde de Porto AlegreGrupo Hospitalar ConceiçãoHospital Mãe de DeusUniversidade Luterana do BrasilUniversidade Luterana do BrasilUniversidade Luterana do BrasilUniversidade Luterana do BrasilBACKGROUND: Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic renal disease on HD. METHODS: This was a multicenter cross-sectional study with 325 patients with chronic renal disease on HD in the period between August 1, 2005 to August 30, 2006, receiving care at four institutions in the city of Porto Alegre, Southern Brazil. Epidemiological data were collected by means of a structured questionnaire. The following laboratory tests were performed: alanine aminotransferase (ALT), anti-hepatitis C virus antibodies (anti-HCV), and qualitative polymerase chain reaction (PCR). RESULTS: Of 325 patients, 68 had positive HCV RNA results. The comparison between patients with positive and negative PCR results revealed significant differences in duration of HD (mean = 71 versus 52.4 months; p = 0.02); previous blood transfusion (92% versus 72%; p < 0.01); injection drug use (13% versus 0.7%; p < 0.01); anti-HCV positivity at start of HD therapy (60% versus 4%; p < 0.01); and mean ALT value (39 versus 26.5; p < 0.01). Logistic regression analysis showed a positive HCV RNA independently associated to being on HD for more than five years [OR: 2.1 (95% CI 1.2 -3.8)]; previous blood transfusion [OR: 3.7 (95% CI 1.4 - 9.5)]; and injection drug use [OR: 22.6 (95% CI 4.2 - 119.6)]. CONCLUSION: Injection drug use was an independent risk factor for HCV infection among chronic renal disease patients on HD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400020&lng=en&tlng=enhepatitis C virushemodialysisinjection drug userisk factors |
| spellingShingle | Bruno Galperim Angelo A Mattos Airton T Stein Nuttiane C Schneider André Buriol André Fonseca Vagner Lunge Nilo Ikuta Hepatitis C in hemodialysis: the contribution of injection drug use Brazilian Journal of Infectious Diseases hepatitis C virus hemodialysis injection drug use risk factors |
| title | Hepatitis C in hemodialysis: the contribution of injection drug use |
| title_full | Hepatitis C in hemodialysis: the contribution of injection drug use |
| title_fullStr | Hepatitis C in hemodialysis: the contribution of injection drug use |
| title_full_unstemmed | Hepatitis C in hemodialysis: the contribution of injection drug use |
| title_short | Hepatitis C in hemodialysis: the contribution of injection drug use |
| title_sort | hepatitis c in hemodialysis the contribution of injection drug use |
| topic | hepatitis C virus hemodialysis injection drug use risk factors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400020&lng=en&tlng=en |
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